Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157008596> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3157008596 endingPage "2858" @default.
- W3157008596 startingPage "2841" @default.
- W3157008596 abstract "The in vitro-to-in vivo extrapolation (IVIVE) methods for predicting the hepatic clearance (CL) of drugs based on microsomal or hepatocyte data have certainly advanced; however, there is still place for improving the extrapolations from in vitro assays containing no plasma proteins. Accordingly, there is a discussion on whether the free drug hypothesis or an albumin (ALB)-mediated hepatic uptake phenomenon is the best scaling method. Therefore, the objectives of this study were to guide the prediction of CL and to diagnose which scaling method between the free drug hypothesis and ALB-mediated uptake could be more accurate; this, irrespective of the mechanism(s) governing CL if the drugs can get to the hepatocyte membrane. The analysis of several datasets demonstrated that almost all values of CL in vivo fall within the two calculated values of CL use as boundaries from: 1) the free drug hypothesis, and 2) ALB-mediated uptake. The average value from these two CL boundaries predicted the CL in vivo with an incredible accuracy. Validating these boundaries in preclinical species prior going to human as well as considering the fractional binding in plasma increased the accuracy. Overall, this study is another step towards guiding the CL prediction in drug discovery and development." @default.
- W3157008596 created "2021-04-26" @default.
- W3157008596 creator A5051609996 @default.
- W3157008596 creator A5070588264 @default.
- W3157008596 date "2021-07-01" @default.
- W3157008596 modified "2023-09-29" @default.
- W3157008596 title "A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo Conditions" @default.
- W3157008596 cites W1970977102 @default.
- W3157008596 cites W1978655276 @default.
- W3157008596 cites W2028784152 @default.
- W3157008596 cites W2031652509 @default.
- W3157008596 cites W2041233844 @default.
- W3157008596 cites W2047951338 @default.
- W3157008596 cites W2061915365 @default.
- W3157008596 cites W2099443896 @default.
- W3157008596 cites W2107755135 @default.
- W3157008596 cites W2130292812 @default.
- W3157008596 cites W2782389743 @default.
- W3157008596 cites W2790700912 @default.
- W3157008596 cites W2792830027 @default.
- W3157008596 cites W2886583669 @default.
- W3157008596 cites W2888153991 @default.
- W3157008596 cites W2888634288 @default.
- W3157008596 cites W2915573543 @default.
- W3157008596 cites W2954033311 @default.
- W3157008596 cites W3038265412 @default.
- W3157008596 cites W3041170713 @default.
- W3157008596 cites W3086006255 @default.
- W3157008596 cites W3095513633 @default.
- W3157008596 cites W3098432204 @default.
- W3157008596 cites W3106468713 @default.
- W3157008596 cites W3112240879 @default.
- W3157008596 cites W3122390182 @default.
- W3157008596 doi "https://doi.org/10.1016/j.xphs.2021.04.002" @default.
- W3157008596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33857483" @default.
- W3157008596 hasPublicationYear "2021" @default.
- W3157008596 type Work @default.
- W3157008596 sameAs 3157008596 @default.
- W3157008596 citedByCount "7" @default.
- W3157008596 countsByYear W31570085962022 @default.
- W3157008596 countsByYear W31570085962023 @default.
- W3157008596 crossrefType "journal-article" @default.
- W3157008596 hasAuthorship W3157008596A5051609996 @default.
- W3157008596 hasAuthorship W3157008596A5070588264 @default.
- W3157008596 hasBestOaLocation W31570085961 @default.
- W3157008596 hasConcept C105795698 @default.
- W3157008596 hasConcept C132459708 @default.
- W3157008596 hasConcept C150903083 @default.
- W3157008596 hasConcept C185592680 @default.
- W3157008596 hasConcept C202751555 @default.
- W3157008596 hasConcept C207001950 @default.
- W3157008596 hasConcept C2776125364 @default.
- W3157008596 hasConcept C2776200302 @default.
- W3157008596 hasConcept C2780035454 @default.
- W3157008596 hasConcept C33923547 @default.
- W3157008596 hasConcept C55493867 @default.
- W3157008596 hasConcept C64903051 @default.
- W3157008596 hasConcept C70721500 @default.
- W3157008596 hasConcept C71924100 @default.
- W3157008596 hasConcept C74187038 @default.
- W3157008596 hasConcept C86803240 @default.
- W3157008596 hasConcept C98274493 @default.
- W3157008596 hasConceptScore W3157008596C105795698 @default.
- W3157008596 hasConceptScore W3157008596C132459708 @default.
- W3157008596 hasConceptScore W3157008596C150903083 @default.
- W3157008596 hasConceptScore W3157008596C185592680 @default.
- W3157008596 hasConceptScore W3157008596C202751555 @default.
- W3157008596 hasConceptScore W3157008596C207001950 @default.
- W3157008596 hasConceptScore W3157008596C2776125364 @default.
- W3157008596 hasConceptScore W3157008596C2776200302 @default.
- W3157008596 hasConceptScore W3157008596C2780035454 @default.
- W3157008596 hasConceptScore W3157008596C33923547 @default.
- W3157008596 hasConceptScore W3157008596C55493867 @default.
- W3157008596 hasConceptScore W3157008596C64903051 @default.
- W3157008596 hasConceptScore W3157008596C70721500 @default.
- W3157008596 hasConceptScore W3157008596C71924100 @default.
- W3157008596 hasConceptScore W3157008596C74187038 @default.
- W3157008596 hasConceptScore W3157008596C86803240 @default.
- W3157008596 hasConceptScore W3157008596C98274493 @default.
- W3157008596 hasIssue "7" @default.
- W3157008596 hasLocation W31570085961 @default.
- W3157008596 hasOpenAccess W3157008596 @default.
- W3157008596 hasPrimaryLocation W31570085961 @default.
- W3157008596 hasRelatedWork W1974290383 @default.
- W3157008596 hasRelatedWork W1983855168 @default.
- W3157008596 hasRelatedWork W1987472191 @default.
- W3157008596 hasRelatedWork W2026040137 @default.
- W3157008596 hasRelatedWork W2029823099 @default.
- W3157008596 hasRelatedWork W2333021946 @default.
- W3157008596 hasRelatedWork W2438771022 @default.
- W3157008596 hasRelatedWork W2525962932 @default.
- W3157008596 hasRelatedWork W2769325772 @default.
- W3157008596 hasRelatedWork W2014611610 @default.
- W3157008596 hasVolume "110" @default.
- W3157008596 isParatext "false" @default.
- W3157008596 isRetracted "false" @default.
- W3157008596 magId "3157008596" @default.
- W3157008596 workType "article" @default.