Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157018684> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W3157018684 endingPage "9" @default.
- W3157018684 startingPage "9" @default.
- W3157018684 abstract "A physiologically-based bio-kinetic (PBBK) model, capable of simulating the absorption, distribution, and elimination of cadmium in humans has been developed. The formulation of this model was based on human data cleaned from literature. The liver, kidney, lung, artery, vein, stomach, small intestine and remainder of the body (other tissues not modelled explicitly) were modelled as compartments. While transfer rate coefficients were used to describe the kinetics of cadmium in the gastrointestinal track, the model used blood flow rates and partition coefficients rather than the traditional transfer rate coefficients to describe the distribution and accumulation of the chemical into critical organs such as liver, kidney and remainder of the body. A perfusion rate-limited kinetics model was assumed for these critical organs, where each of these tissues was regarded as a well-stirred compartment, without any concentration gradient within the compartment. The partition coefficients for critical organs modelled, along with transfer rate coefficients describing oral ingestion and inhalation were estimated by fitting the simulated concentration of cadmium in the liver, kidney and urine to observed concentrations found in literature. The model was capable of simulating, to a good degree of success, the results of empirical observations and other simulations found in literature. Simulations by the model also indicate that the partition coefficient of cadmium for the kidney, liver and other critical organs was higher in smokers." @default.
- W3157018684 created "2021-04-26" @default.
- W3157018684 creator A5003222034 @default.
- W3157018684 creator A5019454850 @default.
- W3157018684 creator A5055358812 @default.
- W3157018684 date "2021-01-01" @default.
- W3157018684 modified "2023-09-26" @default.
- W3157018684 title "A Human Physiologically-based Bio-kinetic Model for Cadmium" @default.
- W3157018684 doi "https://doi.org/10.11648/j.ajmcm.20210601.12" @default.
- W3157018684 hasPublicationYear "2021" @default.
- W3157018684 type Work @default.
- W3157018684 sameAs 3157018684 @default.
- W3157018684 citedByCount "0" @default.
- W3157018684 crossrefType "journal-article" @default.
- W3157018684 hasAuthorship W3157018684A5003222034 @default.
- W3157018684 hasAuthorship W3157018684A5019454850 @default.
- W3157018684 hasAuthorship W3157018684A5055358812 @default.
- W3157018684 hasBestOaLocation W31570186841 @default.
- W3157018684 hasConcept C121332964 @default.
- W3157018684 hasConcept C134018914 @default.
- W3157018684 hasConcept C178790620 @default.
- W3157018684 hasConcept C185592680 @default.
- W3157018684 hasConcept C192552737 @default.
- W3157018684 hasConcept C195289149 @default.
- W3157018684 hasConcept C2780091579 @default.
- W3157018684 hasConcept C43617362 @default.
- W3157018684 hasConcept C544657597 @default.
- W3157018684 hasConcept C55493867 @default.
- W3157018684 hasConcept C62231903 @default.
- W3157018684 hasConcept C86803240 @default.
- W3157018684 hasConcept C97355855 @default.
- W3157018684 hasConceptScore W3157018684C121332964 @default.
- W3157018684 hasConceptScore W3157018684C134018914 @default.
- W3157018684 hasConceptScore W3157018684C178790620 @default.
- W3157018684 hasConceptScore W3157018684C185592680 @default.
- W3157018684 hasConceptScore W3157018684C192552737 @default.
- W3157018684 hasConceptScore W3157018684C195289149 @default.
- W3157018684 hasConceptScore W3157018684C2780091579 @default.
- W3157018684 hasConceptScore W3157018684C43617362 @default.
- W3157018684 hasConceptScore W3157018684C544657597 @default.
- W3157018684 hasConceptScore W3157018684C55493867 @default.
- W3157018684 hasConceptScore W3157018684C62231903 @default.
- W3157018684 hasConceptScore W3157018684C86803240 @default.
- W3157018684 hasConceptScore W3157018684C97355855 @default.
- W3157018684 hasIssue "1" @default.
- W3157018684 hasLocation W31570186841 @default.
- W3157018684 hasOpenAccess W3157018684 @default.
- W3157018684 hasPrimaryLocation W31570186841 @default.
- W3157018684 hasRelatedWork W11050893 @default.
- W3157018684 hasRelatedWork W13991422 @default.
- W3157018684 hasRelatedWork W16228418 @default.
- W3157018684 hasRelatedWork W20681966 @default.
- W3157018684 hasRelatedWork W21419742 @default.
- W3157018684 hasRelatedWork W21690760 @default.
- W3157018684 hasRelatedWork W24870914 @default.
- W3157018684 hasRelatedWork W251604 @default.
- W3157018684 hasRelatedWork W33121857 @default.
- W3157018684 hasRelatedWork W37332447 @default.
- W3157018684 hasVolume "6" @default.
- W3157018684 isParatext "false" @default.
- W3157018684 isRetracted "false" @default.
- W3157018684 magId "3157018684" @default.
- W3157018684 workType "article" @default.