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• W3157019462 abstract "<h2>Abstract</h2><h3>Objectives</h3> To estimate the incidence of dengue infection across geographically distinct areas of Brazil. <h3>Methods</h3> This prospective, household-based, cohort study enrolled participants in five areas and followed them up for up to 4 years (2014–2018). Dengue seroprevalence was assessed at each scheduled visit. Suspected dengue cases were identified through enhanced passive and active surveillance. Acute symptomatic dengue infection was confirmed through reverse-transcriptase quantitative polymerase chain reaction in combination with an antigenic assay (non-structural protein 1) and serology. <h3>Results</h3> Among 3300 participants enrolled, baseline seroprevalence was 76.2%, although only 23.3% of participants reported a history of dengue. Of 1284 suspected symptomatic dengue cases detected, 50 (3.9%) were laboratory-confirmed. Based on 8166.5 person-years (PY) of follow-up, the incidence of laboratory-confirmed symptomatic infection (primary endpoint) was 6.1 per 1000 PY (95% confidence interval [CI]: 4.5, 8.1). Incidence varied substantially in different years (1.8–7.4 per 1000 PY). The incidence of inapparent primary dengue infection was substantially higher: 41.7 per 1000 PY (95% CI: 31.1, 54.6). <h3>Conclusions</h3> Our findings, highlighting that the incidence of dengue infection is underestimated in Brazil, will inform the design and implementation of future dengue vaccine trials. <h3>Clinical trial registration</h3> NCT01751139" @default.
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• W3157019462 date "2021-07-01" @default.
• W3157019462 modified "2023-10-10" @default.
• W3157019462 title "A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014–2018)" @default.
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• W3157019462 doi "https://doi.org/10.1016/j.ijid.2021.04.062" @default.
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