Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157053189> ?p ?o ?g. }
- W3157053189 abstract "There is a growing evidence describing a decline in adaptive homeostasis in aging-related diseases affecting the central nervous system (CNS), many of which are characterized by the appearance of non-native protein aggregates. One signaling pathway that allows cell adaptation is the integrated stress response (ISR), which senses stress stimuli through four kinases. ISR activation promotes translational arrest through the phosphorylation of the eukaryotic translation initiation factor 2 alpha (eIF2α) and the induction of a gene expression program to restore cellular homeostasis. However, depending on the stimulus, ISR can also induce cell death. One of the ISR sensors is the double-stranded RNA-dependent protein kinase [protein kinase R (PKR)], initially described as a viral infection sensor, and now a growing evidence supports a role for PKR on CNS physiology. PKR has been largely involved in the Alzheimer’s disease (AD) pathological process. Here, we reviewed the antecedents supporting the role of PKR on the efficiency of synaptic transmission and cognition. Then, we review PKR’s contribution to AD and discuss the possible participation of PKR as a player in the neurodegenerative process involved in aging-related pathologies affecting the CNS." @default.
- W3157053189 created "2021-05-10" @default.
- W3157053189 creator A5021339869 @default.
- W3157053189 creator A5022005433 @default.
- W3157053189 creator A5084682688 @default.
- W3157053189 date "2021-04-28" @default.
- W3157053189 modified "2023-09-23" @default.
- W3157053189 title "The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration" @default.
- W3157053189 cites W1485494038 @default.
- W3157053189 cites W1499808079 @default.
- W3157053189 cites W1511312105 @default.
- W3157053189 cites W1511705190 @default.
- W3157053189 cites W1545877169 @default.
- W3157053189 cites W1552458995 @default.
- W3157053189 cites W1566646394 @default.
- W3157053189 cites W1596984737 @default.
- W3157053189 cites W1699321428 @default.
- W3157053189 cites W1773363398 @default.
- W3157053189 cites W1776501149 @default.
- W3157053189 cites W1812789667 @default.
- W3157053189 cites W1889314685 @default.
- W3157053189 cites W1903231024 @default.
- W3157053189 cites W1912108616 @default.
- W3157053189 cites W1937509560 @default.
- W3157053189 cites W1949317008 @default.
- W3157053189 cites W1959551399 @default.
- W3157053189 cites W1964173713 @default.
- W3157053189 cites W1965406612 @default.
- W3157053189 cites W1965503161 @default.
- W3157053189 cites W1966959198 @default.
- W3157053189 cites W1970116765 @default.
- W3157053189 cites W1971162704 @default.
- W3157053189 cites W1971278860 @default.
- W3157053189 cites W1972165428 @default.
- W3157053189 cites W1973026127 @default.
- W3157053189 cites W1973376874 @default.
- W3157053189 cites W1973567305 @default.
- W3157053189 cites W1973586624 @default.
- W3157053189 cites W1973765221 @default.
- W3157053189 cites W1974034152 @default.
- W3157053189 cites W1974259300 @default.
- W3157053189 cites W1977569817 @default.
- W3157053189 cites W1977860760 @default.
- W3157053189 cites W1978262065 @default.
- W3157053189 cites W1978340521 @default.
- W3157053189 cites W1979150324 @default.
- W3157053189 cites W1979285338 @default.
- W3157053189 cites W1980452558 @default.
- W3157053189 cites W1982635793 @default.
- W3157053189 cites W1982832390 @default.
- W3157053189 cites W1984253264 @default.
- W3157053189 cites W1985844755 @default.
- W3157053189 cites W1987452659 @default.
- W3157053189 cites W1988873133 @default.
- W3157053189 cites W1990752558 @default.
- W3157053189 cites W1991780813 @default.
- W3157053189 cites W1992279068 @default.
- W3157053189 cites W1992407778 @default.
- W3157053189 cites W1992583586 @default.
- W3157053189 cites W1992601312 @default.
- W3157053189 cites W1996271689 @default.
- W3157053189 cites W1997604339 @default.
- W3157053189 cites W1999175708 @default.
- W3157053189 cites W2000763052 @default.
- W3157053189 cites W2002378374 @default.
- W3157053189 cites W2003283600 @default.
- W3157053189 cites W2004945517 @default.
- W3157053189 cites W2005896461 @default.
- W3157053189 cites W2006011498 @default.
- W3157053189 cites W2007413897 @default.
- W3157053189 cites W2007804566 @default.
- W3157053189 cites W2012695878 @default.
- W3157053189 cites W2013063789 @default.
- W3157053189 cites W2013495374 @default.
- W3157053189 cites W2013806485 @default.
- W3157053189 cites W2017169966 @default.
- W3157053189 cites W2018297253 @default.
- W3157053189 cites W2018708829 @default.
- W3157053189 cites W2021454300 @default.
- W3157053189 cites W2021643601 @default.
- W3157053189 cites W2024828025 @default.
- W3157053189 cites W2027821655 @default.
- W3157053189 cites W2029164422 @default.
- W3157053189 cites W2029415111 @default.
- W3157053189 cites W2030593831 @default.
- W3157053189 cites W2032057219 @default.
- W3157053189 cites W2034632760 @default.
- W3157053189 cites W2036853011 @default.
- W3157053189 cites W2038594716 @default.
- W3157053189 cites W2043901673 @default.
- W3157053189 cites W2044099793 @default.
- W3157053189 cites W2044675465 @default.
- W3157053189 cites W2047565355 @default.
- W3157053189 cites W2050606229 @default.
- W3157053189 cites W2050733310 @default.
- W3157053189 cites W2054181242 @default.
- W3157053189 cites W2055521524 @default.
- W3157053189 cites W2056311398 @default.
- W3157053189 cites W2056636618 @default.
- W3157053189 cites W2056666484 @default.