Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157055173> ?p ?o ?g. }
- W3157055173 abstract "ABSTRACT In response to oncogenic signals, Alternative Splicing (AS) regulators such as SR and hnRNP proteins show altered expression levels, subnuclear distribution and/or post-translational modification status, but the link between signals and these changes remains unknown. Here, we report that a cytosolic scaffold protein, IQGAP1, performs this task in response to heat-induced signals. We show that in gastric cancer cells, a nuclear pool of IQGAP1 acts as a tethering module for a group of spliceosome components, including hnRNPM, a splicing factor critical for the response of the spliceosome to heat-shock. IQGAP1 controls hnRNPM’s sumoylation, subnuclear localization and the relevant response of the AS machinery to heat-induced stress. Genome-wide analyses reveal that IQGAP1 and hnRNPM co-regulate the AS of a cell cycle-related RNA regulon in gastric cancer cells, thus favouring the accelerated proliferation phenotype of gastric cancer cells. Overall, we reveal a missing link between stress signals and AS regulation." @default.
- W3157055173 created "2021-05-10" @default.
- W3157055173 creator A5019068494 @default.
- W3157055173 creator A5034109887 @default.
- W3157055173 creator A5041510189 @default.
- W3157055173 creator A5045271004 @default.
- W3157055173 creator A5055448552 @default.
- W3157055173 creator A5056341752 @default.
- W3157055173 creator A5058328749 @default.
- W3157055173 creator A5065599916 @default.
- W3157055173 creator A5071472550 @default.
- W3157055173 date "2020-05-13" @default.
- W3157055173 modified "2023-09-27" @default.
- W3157055173 title "The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells" @default.
- W3157055173 cites W1529552889 @default.
- W3157055173 cites W1536062643 @default.
- W3157055173 cites W1840284880 @default.
- W3157055173 cites W1883773314 @default.
- W3157055173 cites W1966254873 @default.
- W3157055173 cites W1966815294 @default.
- W3157055173 cites W1972083681 @default.
- W3157055173 cites W1973469290 @default.
- W3157055173 cites W1975283078 @default.
- W3157055173 cites W1977709885 @default.
- W3157055173 cites W1985643113 @default.
- W3157055173 cites W1986818022 @default.
- W3157055173 cites W1994659759 @default.
- W3157055173 cites W1999609473 @default.
- W3157055173 cites W2009258895 @default.
- W3157055173 cites W2011279016 @default.
- W3157055173 cites W2011920499 @default.
- W3157055173 cites W2019275546 @default.
- W3157055173 cites W2024090897 @default.
- W3157055173 cites W2032755148 @default.
- W3157055173 cites W2037984694 @default.
- W3157055173 cites W2043586610 @default.
- W3157055173 cites W2062044848 @default.
- W3157055173 cites W2070976067 @default.
- W3157055173 cites W2077026062 @default.
- W3157055173 cites W2077338924 @default.
- W3157055173 cites W2078779750 @default.
- W3157055173 cites W2079078062 @default.
- W3157055173 cites W2085364628 @default.
- W3157055173 cites W2086859115 @default.
- W3157055173 cites W2088357489 @default.
- W3157055173 cites W2092759184 @default.
- W3157055173 cites W2093842915 @default.
- W3157055173 cites W2094922317 @default.
- W3157055173 cites W2095998476 @default.
- W3157055173 cites W2110538588 @default.
- W3157055173 cites W2114822038 @default.
- W3157055173 cites W2114843025 @default.
- W3157055173 cites W2117506397 @default.
- W3157055173 cites W2119497951 @default.
- W3157055173 cites W2125254271 @default.
- W3157055173 cites W2125782175 @default.
- W3157055173 cites W2128569116 @default.
- W3157055173 cites W2133841696 @default.
- W3157055173 cites W2135279715 @default.
- W3157055173 cites W2139480055 @default.
- W3157055173 cites W2139897259 @default.
- W3157055173 cites W2149441684 @default.
- W3157055173 cites W2153599010 @default.
- W3157055173 cites W2156508926 @default.
- W3157055173 cites W2159998873 @default.
- W3157055173 cites W2171018097 @default.
- W3157055173 cites W2307041907 @default.
- W3157055173 cites W2307792848 @default.
- W3157055173 cites W2339326063 @default.
- W3157055173 cites W2341120186 @default.
- W3157055173 cites W2472633990 @default.
- W3157055173 cites W2569614730 @default.
- W3157055173 cites W2600708768 @default.
- W3157055173 cites W2763234678 @default.
- W3157055173 cites W2769618080 @default.
- W3157055173 cites W2800128567 @default.
- W3157055173 cites W2804603137 @default.
- W3157055173 cites W2811106513 @default.
- W3157055173 cites W2883625644 @default.
- W3157055173 cites W2885227878 @default.
- W3157055173 cites W2889778242 @default.
- W3157055173 cites W2890052597 @default.
- W3157055173 cites W2907177719 @default.
- W3157055173 cites W2945292628 @default.
- W3157055173 cites W2946684248 @default.
- W3157055173 cites W2949471351 @default.
- W3157055173 cites W3015585996 @default.
- W3157055173 cites W3047005263 @default.
- W3157055173 cites W4231159240 @default.
- W3157055173 cites W4293247451 @default.
- W3157055173 doi "https://doi.org/10.1101/2020.05.11.089656" @default.
- W3157055173 hasPublicationYear "2020" @default.
- W3157055173 type Work @default.
- W3157055173 sameAs 3157055173 @default.
- W3157055173 citedByCount "1" @default.
- W3157055173 countsByYear W31570551732022 @default.
- W3157055173 crossrefType "posted-content" @default.
- W3157055173 hasAuthorship W3157055173A5019068494 @default.
- W3157055173 hasAuthorship W3157055173A5034109887 @default.
- W3157055173 hasAuthorship W3157055173A5041510189 @default.