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• W3157104543 abstract "Left ventricular (LV) apical aneurysm occurs in <5% of patients with hypertrophic cardiomyopathy (HCM) likely as a result of subendocardial ischemia from increased myocardial mass and/or increased intraventricular pressure in the setting of LV outflow obstruction. [ [1] Matsubara K. Nakamura T. Kuribayashi T. Azuma A. Nakagawa M. Sustained cavity obliteration and apical aneurysm formation in apical hypertrophic cardiomyopathy. J. Am. Coll. Cardiol. 2003 Jul; 42: 288-295 Crossref PubMed Scopus (98) Google Scholar , [2] Lu D.-Y. Hailesealassie B. Ventoulis I. Liu H. Liang H.-Y. Nowbar A. et al. Impact of peak provoked left ventricular outflow tract gradients on clinical outcomes in hypertrophic cardiomyopathy. Int. J. Cardiol. 2017 Sep; 243: 290-295 Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar ] Its clinical significance lies in its association with increased risk for sudden cardiac death (SCD), ventricular arrhythmias, thromboembolic events and potentially worse heart failure. In the largest study to date which included 93 patients with HCM and LV apical aneurysm, Rowin et al. [ [3] Rowin E.J. Maron B.J. Haas T.S. Garberich R.F. Wang W. Link M.S. et al. Hypertrophic cardiomyopathy with left ventricular apical aneurysm: implications for risk stratification and management. J. Am. Coll. Cardiol. 2017 Feb; 69: 761-773 Crossref PubMed Scopus (129) Google Scholar ] reported SCD and thromboembolic events at a rate of around 5% and 1% per year respectively. The results of this as well as other smaller retrospective studies [ [4] Minami Y. Haruki S. Hagiwara N. Phenotypic overlap in hypertrophic cardiomyopathy: apical hypertrophy, midventricular obstruction, and apical aneurysm. J. Cardiol. 2014 Dec; 64: 463-469 Abstract Full Text Full Text PDF PubMed Scopus (24) Google Scholar , [5] Hanneman K. Crean A.M. Williams L. Moshonov H. James S. Jiménez-Juan L. et al. Cardiac magnetic resonance imaging findings predict major adverse events in apical hypertrophic cardiomyopathy. J. Thorac. Imaging. 2014 Nov; 29: 331-339 Crossref PubMed Scopus (27) Google Scholar ] led to the inclusion of LV apical aneurysm as a new established clinical risk factor for SCD in HCM patients with a class IIa recommendation for ICD in the most recent 2020 ACC/AHA Guidelines. [ [6] Ommen S.R. Mital S. Burke M.A. Day S.M. Deswal A. Elliott P. et al. AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines. Vol. 76. J. Am. Coll. Cardiol. United States. 2020; 2020: 3022-3055 Crossref Scopus (20) Google Scholar ] Anticoagulation was not explicitly recommended in the absence of atrial fibrillation. Prognostic role of left ventricular apical aneurysm in hypertrophic cardiomyopathy: A systematic review and meta-analysisInternational Journal of CardiologyVol. 332PreviewThe aim of this study was to systematically review and quantitatively synthesize existing evidence about the prognostic value of LV apical aneurysm in patients with HCM. Full-Text PDF" @default.
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• W3157104543 date "2021-07-01" @default.
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• W3157104543 title "LV apical aneurysm in HCM: Implant ICD and anticoagulate?" @default.
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• W3157104543 doi "https://doi.org/10.1016/j.ijcard.2021.04.044" @default.
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