Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157136099> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3157136099 endingPage "90" @default.
- W3157136099 startingPage "84" @default.
- W3157136099 abstract "Few studies have been performed to investigate the effect of vitamin D supplementation and T2DM in type 2 diabetic animal models. The present study aimed to explore the relationship between early 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and the incidence of T2DM and determine whether early 1,25(OH)2D3 supplementation was associated with inflammation in KK-Ay mice. The KK-Ay mice were divided into 4 vitamin D treatment groups, the low-dose vitamin D supplementation group (VDS-L, 1.5 μg/kg 1,25(OH)2D3), moderate-dose vitamin D supplementation group (VDS-M, 3.0 μg/kg 1,25(OH)2D3), high-dose vitamin D supplementation group (VDS-H, 6.0 μg/kg 1,25(OH)2D3) and the model control group (MC). C57BL/6J mice were used as the controls. The treatment period lasted for 9 wk. During this treatment period, fasting blood glucose (FBG) level of the mice was measured on a weekly basis. The levels of lipid profile, insulin and inflammation biomarkers were determined after 9 wk of 1,25(OH)2D3 intragastric gavage. After 9 wk of 1,25(OH)2D3 intragastric gavage, FBG level was significantly decreased in the vitamin D treatment groups compared with the MC group. The number of T2DM incidence in the VDS-L group (n=7), VDS-M group (n=5) and VDS-H group (n=3) was lower than those in the MC group (n=10) on week 9. Moreover, serum C-reactive protein (CRP) and interleukin-6 (IL-6) in the vitamin D treatment groups were significantly suppressed by 1,25(OH)2D3 administration compared with the MC group. Early 1,25(OH)2D3 supplementation could effectively lower the incidence of T2DM via ameliorating inflammation in KK-Ay mice." @default.
- W3157136099 created "2021-05-10" @default.
- W3157136099 creator A5024960231 @default.
- W3157136099 creator A5029095012 @default.
- W3157136099 creator A5049235665 @default.
- W3157136099 creator A5069268440 @default.
- W3157136099 creator A5072736924 @default.
- W3157136099 creator A5079417178 @default.
- W3157136099 date "2021-04-30" @default.
- W3157136099 modified "2023-10-06" @default.
- W3157136099 title "Early 1,25-Dihydroxyvitamin D<sub>3</sub> Supplementation Effectively Lowers the Incidence of Type 2 Diabetes Mellitus via Ameliorating Inflammation In KK-A<sup>y</sup> Mice" @default.
- W3157136099 cites W1592266520 @default.
- W3157136099 cites W1964139383 @default.
- W3157136099 cites W1965534948 @default.
- W3157136099 cites W1967130085 @default.
- W3157136099 cites W1967386430 @default.
- W3157136099 cites W1978357971 @default.
- W3157136099 cites W1979064868 @default.
- W3157136099 cites W1979785484 @default.
- W3157136099 cites W198103589 @default.
- W3157136099 cites W1991736636 @default.
- W3157136099 cites W2001235001 @default.
- W3157136099 cites W2015753105 @default.
- W3157136099 cites W2016480066 @default.
- W3157136099 cites W2026514466 @default.
- W3157136099 cites W2054671811 @default.
- W3157136099 cites W2065925810 @default.
- W3157136099 cites W2076462603 @default.
- W3157136099 cites W2086889024 @default.
- W3157136099 cites W2088832793 @default.
- W3157136099 cites W2095731933 @default.
- W3157136099 cites W2099353808 @default.
- W3157136099 cites W2099479777 @default.
- W3157136099 cites W2104285596 @default.
- W3157136099 cites W2131909681 @default.
- W3157136099 cites W2140694890 @default.
- W3157136099 cites W2150367899 @default.
- W3157136099 cites W2166608053 @default.
- W3157136099 cites W2167476522 @default.
- W3157136099 cites W2196651542 @default.
- W3157136099 cites W2299400929 @default.
- W3157136099 cites W2601492960 @default.
- W3157136099 cites W2771243423 @default.
- W3157136099 cites W2809862735 @default.
- W3157136099 cites W2903345357 @default.
- W3157136099 doi "https://doi.org/10.3177/jnsv.67.84" @default.
- W3157136099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33952739" @default.
- W3157136099 hasPublicationYear "2021" @default.
- W3157136099 type Work @default.
- W3157136099 sameAs 3157136099 @default.
- W3157136099 citedByCount "3" @default.
- W3157136099 countsByYear W31571360992022 @default.
- W3157136099 countsByYear W31571360992023 @default.
- W3157136099 crossrefType "journal-article" @default.
- W3157136099 hasAuthorship W3157136099A5024960231 @default.
- W3157136099 hasAuthorship W3157136099A5029095012 @default.
- W3157136099 hasAuthorship W3157136099A5049235665 @default.
- W3157136099 hasAuthorship W3157136099A5069268440 @default.
- W3157136099 hasAuthorship W3157136099A5072736924 @default.
- W3157136099 hasAuthorship W3157136099A5079417178 @default.
- W3157136099 hasBestOaLocation W31571360991 @default.
- W3157136099 hasConcept C124490489 @default.
- W3157136099 hasConcept C126322002 @default.
- W3157136099 hasConcept C134018914 @default.
- W3157136099 hasConcept C2776914184 @default.
- W3157136099 hasConcept C2777180221 @default.
- W3157136099 hasConcept C2777391703 @default.
- W3157136099 hasConcept C2779740938 @default.
- W3157136099 hasConcept C555293320 @default.
- W3157136099 hasConcept C71924100 @default.
- W3157136099 hasConceptScore W3157136099C124490489 @default.
- W3157136099 hasConceptScore W3157136099C126322002 @default.
- W3157136099 hasConceptScore W3157136099C134018914 @default.
- W3157136099 hasConceptScore W3157136099C2776914184 @default.
- W3157136099 hasConceptScore W3157136099C2777180221 @default.
- W3157136099 hasConceptScore W3157136099C2777391703 @default.
- W3157136099 hasConceptScore W3157136099C2779740938 @default.
- W3157136099 hasConceptScore W3157136099C555293320 @default.
- W3157136099 hasConceptScore W3157136099C71924100 @default.
- W3157136099 hasIssue "2" @default.
- W3157136099 hasLocation W31571360991 @default.
- W3157136099 hasOpenAccess W3157136099 @default.
- W3157136099 hasPrimaryLocation W31571360991 @default.
- W3157136099 hasRelatedWork W1824985903 @default.
- W3157136099 hasRelatedWork W1975759361 @default.
- W3157136099 hasRelatedWork W2056158716 @default.
- W3157136099 hasRelatedWork W2071103727 @default.
- W3157136099 hasRelatedWork W2107762597 @default.
- W3157136099 hasRelatedWork W2147487489 @default.
- W3157136099 hasRelatedWork W2351349280 @default.
- W3157136099 hasRelatedWork W2586852390 @default.
- W3157136099 hasRelatedWork W3006763344 @default.
- W3157136099 hasRelatedWork W4229053620 @default.
- W3157136099 hasVolume "67" @default.
- W3157136099 isParatext "false" @default.
- W3157136099 isRetracted "false" @default.
- W3157136099 magId "3157136099" @default.
- W3157136099 workType "article" @default.