FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157136401> ?p ?o ?g. }

• W3157136401 abstract "Globally, human papilloma virus (HPV) infection is a common sexually transmitted disease. However, most of the HPV infections eventually resolve aided by the body’s efficient cell-mediated immune responses. In the vast majority of the small group of patients who develop overt disease too, it is the immune response that culminates in regression of lesions. It is therefore a rarity that persistent infection by high-risk genotypes of HPV compounded by other risk factors progresses through precancer (various grades of cervical intraepithelial neoplasia—CIN) to cervical cancer (CxCa). Hence, although CxCa is a rare culmination of HPV infection, the latter is nevertheless causally linked to &gt;90% of cancer. The three ‘Es’ of cancer immunoediting viz. elimination, equilibrium, and escape come into vogue during the gradual evolution of CIN 1 to CxCa. Both cell-intrinsic and extrinsic mechanisms operate to eliminate virally infected cells: cell-extrinsic players are anti-tumor/antiviral effectors like Th1 subset of CD4+ T cells, CD8+ cytotoxic T cells, Natural Killer cells, etc . and pro-tumorigenic/immunosuppressive cells like regulatory T cells (Tregs), Myeloid-Derived Suppressor Cells (MDSCs), type 2 macrophages, etc . And accordingly, when immunosuppressive cells overpower the effectors e.g ., in high-grade lesions like CIN 2 or 3, the scale is tilted towards immune escape and the disease progresses to cancer. Estradiol has long been considered as a co-factor in cervical carcinogenesis. In addition to the gonads, the Peyer’s patches in the gut synthesize estradiol. Over and above local production of the hormone in the tissues, estradiol metabolism by the gut microbiome: estrobolome versus tryptophan non-metabolizing microbiome, regulates free estradiol levels in the intestine and extraintestinal mucosal sites. Elevated tissue levels of the hormone serve more than one purpose: besides a direct growth-promoting action on cervical epithelial cells, estradiol acting genomically via Estrogen Receptor- α also boosts the function of the stromal and infiltrating immunosuppressive cells viz . Tregs, MDSCs, and carcinoma-associated fibroblasts. Hence as a corollary, therapeutic repurposing of Selective Estrogen Receptor Disruptors or aromatase inhibitors could be useful for modulating immune function in cervical precancer/cancer. The immunomodulatory role of estradiol in HPV-mediated cervical lesions is reviewed." @default.
• W3157136401 created "2021-05-10" @default.
• W3157136401 creator A5077768903 @default.
• W3157136401 date "2021-04-30" @default.
• W3157136401 modified "2023-10-18" @default.
• W3157136401 title "The Immune Microenvironment in Human Papilloma Virus-Induced Cervical Lesions—Evidence for Estrogen as an Immunomodulator" @default.
• W3157136401 cites W1492665086 @default.
• W3157136401 cites W1516386879 @default.
• W3157136401 cites W1529878417 @default.
• W3157136401 cites W1551587823 @default.
• W3157136401 cites W1562069246 @default.
• W3157136401 cites W1566992315 @default.
• W3157136401 cites W1620032110 @default.
• W3157136401 cites W1640854798 @default.
• W3157136401 cites W1827550384 @default.
• W3157136401 cites W1833987578 @default.
• W3157136401 cites W1854951549 @default.
• W3157136401 cites W1875984885 @default.
• W3157136401 cites W1906960897 @default.
• W3157136401 cites W1934401152 @default.
• W3157136401 cites W1968194779 @default.
• W3157136401 cites W1968354595 @default.
• W3157136401 cites W1969397804 @default.
• W3157136401 cites W1971377807 @default.
• W3157136401 cites W1972505691 @default.
• W3157136401 cites W1973599173 @default.
• W3157136401 cites W1981725818 @default.
• W3157136401 cites W1982342760 @default.
• W3157136401 cites W1983050089 @default.
• W3157136401 cites W1984619729 @default.
• W3157136401 cites W1987819795 @default.
• W3157136401 cites W1988474688 @default.
• W3157136401 cites W1988659428 @default.
• W3157136401 cites W1992196376 @default.
• W3157136401 cites W1993680169 @default.
• W3157136401 cites W1996741498 @default.
• W3157136401 cites W1996964551 @default.
• W3157136401 cites W2000947221 @default.
• W3157136401 cites W2003422299 @default.
• W3157136401 cites W2003472707 @default.
• W3157136401 cites W2017558201 @default.
• W3157136401 cites W2018296662 @default.
• W3157136401 cites W2018646351 @default.
• W3157136401 cites W2019054269 @default.
• W3157136401 cites W2021628531 @default.
• W3157136401 cites W2023084443 @default.
• W3157136401 cites W2023640026 @default.
• W3157136401 cites W2024575518 @default.
• W3157136401 cites W2027198537 @default.
• W3157136401 cites W2030560379 @default.
• W3157136401 cites W2033278321 @default.
• W3157136401 cites W2033309377 @default.
• W3157136401 cites W2035208235 @default.
• W3157136401 cites W2037342985 @default.
• W3157136401 cites W2039745983 @default.
• W3157136401 cites W2040786243 @default.
• W3157136401 cites W2040927104 @default.
• W3157136401 cites W2042846292 @default.
• W3157136401 cites W2043652943 @default.
• W3157136401 cites W2043718105 @default.
• W3157136401 cites W2043746949 @default.
• W3157136401 cites W2045693157 @default.
• W3157136401 cites W2047846334 @default.
• W3157136401 cites W2049440873 @default.
• W3157136401 cites W2050586039 @default.
• W3157136401 cites W2052018973 @default.
• W3157136401 cites W2053163556 @default.
• W3157136401 cites W2056783168 @default.
• W3157136401 cites W2060071366 @default.
• W3157136401 cites W2060672294 @default.
• W3157136401 cites W2061099728 @default.
• W3157136401 cites W2061361679 @default.
• W3157136401 cites W2062783581 @default.
• W3157136401 cites W2064157766 @default.
• W3157136401 cites W2064273388 @default.
• W3157136401 cites W2066332001 @default.
• W3157136401 cites W2066788310 @default.
• W3157136401 cites W2069906370 @default.
• W3157136401 cites W2071110150 @default.
• W3157136401 cites W2071507111 @default.
• W3157136401 cites W2073285464 @default.
• W3157136401 cites W2075281841 @default.
• W3157136401 cites W2076232020 @default.
• W3157136401 cites W2076687077 @default.
• W3157136401 cites W2076776930 @default.
• W3157136401 cites W2076862423 @default.
• W3157136401 cites W2080006053 @default.
• W3157136401 cites W2080675024 @default.
• W3157136401 cites W2081831291 @default.
• W3157136401 cites W2084416533 @default.
• W3157136401 cites W2084545547 @default.
• W3157136401 cites W2085547918 @default.
• W3157136401 cites W2088783992 @default.
• W3157136401 cites W2089265092 @default.
• W3157136401 cites W2089896895 @default.
• W3157136401 cites W2089899954 @default.
• W3157136401 cites W2092275144 @default.
• W3157136401 cites W2098491904 @default.
• W3157136401 cites W2100141308 @default.
• W3157136401 cites W2100474263 @default.

• next