FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157143025> ?p ?o ?g. }

• W3157143025 endingPage "4490" @default.
• W3157143025 startingPage "4490" @default.
• W3157143025 abstract "Cytoguardin was identified in the conditioned medium of fibroblasts as a tryptophan metabolite, 5-methoxytryptophan (5-MTP). It is synthesized via two enzymatic steps: tryptophan hydroxylase (TPH) and hydroxyindole O-methyltransferase (HIOMT). A truncated HIOMT isoform, HIOMT298, catalyzes 5-MTP synthesis. Cancer cells produce scarce 5-MTP due to defective HIOMT298 expression. 5-MTP inhibits cancer cell COX-2 expression and thereby reduces COX-2-mediated cell proliferation and migration. 5-MTP also inhibits MMP-9 expression and thereby reduces cancer cell invasion. 5-MTP exerts its anti-cancer effect by blocking p38 MAPK and p38-mediated NF-κB and p300 HAT activation. The stable transfection of A549 cells with HIOMT298 restores 5-MTP production which renders cancer cells less aggressive. The implantation of HIOMT-transfected A549 into subcutaneous tissues of a murine xenograft tumor model shows that HIOMT-transduced A549 cells form smaller tumors and generate fewer metastatic lung nodules than control A549 cells. HIOMT298 transfection suppresses aromatic amino acid decarboxylase (AADC) expression and serotonin production. Serotonin is a cancer-promoting factor. By restoring 5-MTP and suppressing serotonin production, HIOMT298 overexpression converts cancer cells into less malignant phenotypes. The analysis of HIOMT expression in a human cancer tissue array showed reduced HIOMT levels in a majority of colorectal, pancreatic, and breast cancer. HIOMT298 may be a biomarker of human cancer progression. Furthermore, 5-MTP has the potential to be a lead compound in the development of new therapy for the chemoprevention of certain cancers such as hepatocellular cancer." @default.
• W3157143025 created "2021-05-10" @default.
• W3157143025 creator A5035975194 @default.
• W3157143025 date "2021-04-26" @default.
• W3157143025 modified "2023-10-18" @default.
• W3157143025 title "Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis" @default.
• W3157143025 cites W1553107571 @default.
• W3157143025 cites W1562048214 @default.
• W3157143025 cites W1669486342 @default.
• W3157143025 cites W1911021594 @default.
• W3157143025 cites W1922458582 @default.
• W3157143025 cites W1930083400 @default.
• W3157143025 cites W1959606306 @default.
• W3157143025 cites W1969888297 @default.
• W3157143025 cites W1969909043 @default.
• W3157143025 cites W1974160989 @default.
• W3157143025 cites W1975560535 @default.
• W3157143025 cites W1976973627 @default.
• W3157143025 cites W1979521500 @default.
• W3157143025 cites W1983710466 @default.
• W3157143025 cites W1989204866 @default.
• W3157143025 cites W1990156357 @default.
• W3157143025 cites W1993223905 @default.
• W3157143025 cites W1998142996 @default.
• W3157143025 cites W2000598142 @default.
• W3157143025 cites W2002955373 @default.
• W3157143025 cites W2008374414 @default.
• W3157143025 cites W2008811049 @default.
• W3157143025 cites W2012124753 @default.
• W3157143025 cites W2013959132 @default.
• W3157143025 cites W2014209078 @default.
• W3157143025 cites W2019558125 @default.
• W3157143025 cites W2020154755 @default.
• W3157143025 cites W2020407332 @default.
• W3157143025 cites W2020532704 @default.
• W3157143025 cites W2029174913 @default.
• W3157143025 cites W2031624613 @default.
• W3157143025 cites W2037745595 @default.
• W3157143025 cites W2045994102 @default.
• W3157143025 cites W2048680922 @default.
• W3157143025 cites W2054263994 @default.
• W3157143025 cites W2056772627 @default.
• W3157143025 cites W2059352599 @default.
• W3157143025 cites W2059421466 @default.
• W3157143025 cites W2062809449 @default.
• W3157143025 cites W2066706367 @default.
• W3157143025 cites W2070390017 @default.
• W3157143025 cites W2074168286 @default.
• W3157143025 cites W2081729013 @default.
• W3157143025 cites W2083139200 @default.
• W3157143025 cites W2084472730 @default.
• W3157143025 cites W2091487108 @default.
• W3157143025 cites W2095552204 @default.
• W3157143025 cites W2113754791 @default.
• W3157143025 cites W2119689902 @default.
• W3157143025 cites W2123095347 @default.
• W3157143025 cites W2143758659 @default.
• W3157143025 cites W2144030304 @default.
• W3157143025 cites W2149848093 @default.
• W3157143025 cites W2151901676 @default.
• W3157143025 cites W2159921466 @default.
• W3157143025 cites W2162501548 @default.
• W3157143025 cites W2272272265 @default.
• W3157143025 cites W2312161555 @default.
• W3157143025 cites W2344113909 @default.
• W3157143025 cites W2346261156 @default.
• W3157143025 cites W2412040295 @default.
• W3157143025 cites W2552318961 @default.
• W3157143025 cites W2612273295 @default.
• W3157143025 cites W2750746399 @default.
• W3157143025 cites W2799668726 @default.
• W3157143025 cites W2803849173 @default.
• W3157143025 cites W2942900286 @default.
• W3157143025 cites W2969583426 @default.
• W3157143025 cites W2979555273 @default.
• W3157143025 cites W3010908253 @default.
• W3157143025 cites W3040512414 @default.
• W3157143025 cites W4232620598 @default.
• W3157143025 doi "https://doi.org/10.3390/ijms22094490" @default.
• W3157143025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8123408" @default.
• W3157143025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33925793" @default.
• W3157143025 hasPublicationYear "2021" @default.
• W3157143025 type Work @default.
• W3157143025 sameAs 3157143025 @default.
• W3157143025 citedByCount "9" @default.
• W3157143025 countsByYear W31571430252021 @default.
• W3157143025 countsByYear W31571430252022 @default.
• W3157143025 countsByYear W31571430252023 @default.
• W3157143025 crossrefType "journal-article" @default.
• W3157143025 hasAuthorship W3157143025A5035975194 @default.
• W3157143025 hasBestOaLocation W31571430251 @default.
• W3157143025 hasConcept C104317684 @default.
• W3157143025 hasConcept C121608353 @default.
• W3157143025 hasConcept C126322002 @default.
• W3157143025 hasConcept C1491633281 @default.
• W3157143025 hasConcept C185592680 @default.
• W3157143025 hasConcept C2776256026 @default.
• W3157143025 hasConcept C2780210213 @default.

• next