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- W3157149257 abstract "Beclin-1 was bound to and inhibited by Bcl-2 or the Bcl-2 homolog Bcl-XL, this interaction involves a Bcl-2 homology 3 (BH3) domain in Beclin-1 and the BH3 binding groove of Bcl-2/Bcl-XL. In order to find a new BH3-mimetic compound to disrupt the combination of Beclin-1 and Bcl-2 and promote autophagy, we used the HipHop for screening novel potential BH3-mimetic compounds. The hit compounds were subjected to docking study to verify the correctness of screening and pick the optimization. Finally, two compounds were selected to carry out biology experiment, and both have a higher induction potency of autophagy in vitro." @default.
- W3157149257 created "2021-05-10" @default.
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- W3157149257 date "2021-03-01" @default.
- W3157149257 modified "2023-09-27" @default.
- W3157149257 title "Pharmacophore study using the HipHop for the screening novel potential BH3-mimetic compounds" @default.
- W3157149257 doi "https://doi.org/10.1109/healthcom49281.2021.9399022" @default.
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