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- W3157155714 abstract "Abstract Granulosa cells, supporting cells of the ovary, are essential for ovarian differentiation by providing a nurturing environment for oogenesis. Sufficient numbers of granulosa cells are vital for establishment of follicles and the oocyte reserve; therefore, identifying the cellular source from which granulosa cells are derived is critical for understanding basic ovarian biology. One cell type that has received little attention in this field is the perivascular cell. Here we use lineage tracing and organ culture techniques in mice to identify ovarian Nestin+ perivascular cells as multipotent progenitors that contribute to granulosa, thecal, and pericyte lineages. Maintenance of these progenitors was dependent on vascular-mesenchymal Notch signaling. Ablation of postnatal Nestin+ cells resulted in a disruption of granulosa cell specification and an increased incidence of polyovular ovarian follicles, thus uncovering key roles for vasculature in ovarian differentiation. These findings may provide new insights into the origins of female gonad dysgenesis and infertility." @default.
- W3157155714 created "2021-05-10" @default.
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- W3157155714 date "2021-04-27" @default.
- W3157155714 modified "2023-09-26" @default.
- W3157155714 title "Perivascular cells support folliculogenesis in the developing ovary" @default.
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- W3157155714 doi "https://doi.org/10.1101/2021.04.26.441453" @default.
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