FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157164906> ?p ?o ?g. }

• W3157164906 endingPage "680" @default.
• W3157164906 startingPage "667" @default.
• W3157164906 abstract "Abstract Background Candida albicans , the main human fungal pathogen, can cause fungal infection and seriously affect people's health and life. This study aimed to investigate the effects of ritonavir (RIT) on C. albicans and the correlation between SAP2 as well as ERG11 and drug resistance. Results Secreted aspartyl proteinases (Saps) activities and pathogenicity of C. albicans with different drug resistance were measured. M27‐A4 broth microdilution method was used to analyze the drug sensitivity of RIT combined with fluconazole (FCA) on C. albicans . After that, SAP2 and ERG11 mutations were examined by polymerase chain reaction (PCR) and sequencing, and quantitative real‐time PCR was utilized to determine the expression of the two genes. By analyzing p z values, the Saps activity of cross‐resistant strains was the highest, followed by voriconazole (VRC)‐resistant strains, FCA‐resistant strains, itraconazole (ITR)‐resistant strains, and sensitive strains. The pathogenicity of C. albicans in descending order was as follows: cross‐resistant strains, VRC‐resistant strains, ITR‐resistant strains, FCA‐resistant strains, and sensitive strains. With the increase of RIT concentrations, the Saps activity was gradually inhibited. Drug sensitivity results showed that there was no synergistic effect between RIT and FCA. Additionally, no gene mutation sites were found in SAP2 sequencing, and 17 synonymous mutations and 6 missense mutations occurred in ERG11 sequencing. Finally, the expression of SAP2 and ERG11 was significantly higher in the resistant strains compared with the sensitive strains, and there was a positive liner correlation between SAP2 and ERG11 messenger RNA expression ( r = .6655, p < .001). Conclusion These findings may help to improve our understanding of azole‐resistant mechanisms of C. albicans and provide a novel direction for clinical therapeutics of C. albicans infection." @default.
• W3157164906 created "2021-05-10" @default.
• W3157164906 creator A5028055208 @default.
• W3157164906 creator A5039951114 @default.
• W3157164906 creator A5052237989 @default.
• W3157164906 creator A5053143384 @default.
• W3157164906 creator A5075495824 @default.
• W3157164906 creator A5078316900 @default.
• W3157164906 creator A5090763730 @default.
• W3157164906 date "2021-05-05" @default.
• W3157164906 modified "2023-10-18" @default.
• W3157164906 title "The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles‐resistant strains of <i>Candida albicans</i> as well as regulatory role of <i>SAP2</i> and <i>ERG11</i>" @default.
• W3157164906 cites W1479708815 @default.
• W3157164906 cites W1577845999 @default.
• W3157164906 cites W1798022500 @default.
• W3157164906 cites W1937099021 @default.
• W3157164906 cites W1970375581 @default.
• W3157164906 cites W1996996320 @default.
• W3157164906 cites W2004503571 @default.
• W3157164906 cites W2022531352 @default.
• W3157164906 cites W2035516863 @default.
• W3157164906 cites W2042146008 @default.
• W3157164906 cites W2045238499 @default.
• W3157164906 cites W2061302244 @default.
• W3157164906 cites W2104507335 @default.
• W3157164906 cites W2106462595 @default.
• W3157164906 cites W2113979173 @default.
• W3157164906 cites W2116830493 @default.
• W3157164906 cites W2124304315 @default.
• W3157164906 cites W2129022436 @default.
• W3157164906 cites W2135019245 @default.
• W3157164906 cites W2144035662 @default.
• W3157164906 cites W2152348290 @default.
• W3157164906 cites W2159273389 @default.
• W3157164906 cites W2173204038 @default.
• W3157164906 cites W2419322534 @default.
• W3157164906 cites W2460173856 @default.
• W3157164906 cites W2463772967 @default.
• W3157164906 cites W2564016800 @default.
• W3157164906 cites W2589194477 @default.
• W3157164906 cites W2593299479 @default.
• W3157164906 cites W2770669522 @default.
• W3157164906 cites W2899405653 @default.
• W3157164906 cites W2933040721 @default.
• W3157164906 cites W2979458457 @default.
• W3157164906 cites W2983504407 @default.
• W3157164906 cites W2985131790 @default.
• W3157164906 cites W2996478583 @default.
• W3157164906 cites W3157164906 @default.
• W3157164906 cites W4211042503 @default.
• W3157164906 doi "https://doi.org/10.1002/iid3.415" @default.
• W3157164906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8342201" @default.
• W3157164906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33951330" @default.
• W3157164906 hasPublicationYear "2021" @default.
• W3157164906 type Work @default.
• W3157164906 sameAs 3157164906 @default.
• W3157164906 citedByCount "6" @default.
• W3157164906 countsByYear W31571649062021 @default.
• W3157164906 countsByYear W31571649062022 @default.
• W3157164906 countsByYear W31571649062023 @default.
• W3157164906 crossrefType "journal-article" @default.
• W3157164906 hasAuthorship W3157164906A5028055208 @default.
• W3157164906 hasAuthorship W3157164906A5039951114 @default.
• W3157164906 hasAuthorship W3157164906A5052237989 @default.
• W3157164906 hasAuthorship W3157164906A5053143384 @default.
• W3157164906 hasAuthorship W3157164906A5075495824 @default.
• W3157164906 hasAuthorship W3157164906A5078316900 @default.
• W3157164906 hasAuthorship W3157164906A5090763730 @default.
• W3157164906 hasBestOaLocation W31571649061 @default.
• W3157164906 hasConcept C114851261 @default.
• W3157164906 hasConcept C145081991 @default.
• W3157164906 hasConcept C2779548794 @default.
• W3157164906 hasConcept C2780651595 @default.
• W3157164906 hasConcept C2780690907 @default.
• W3157164906 hasConcept C2780917455 @default.
• W3157164906 hasConcept C86803240 @default.
• W3157164906 hasConcept C89423630 @default.
• W3157164906 hasConceptScore W3157164906C114851261 @default.
• W3157164906 hasConceptScore W3157164906C145081991 @default.
• W3157164906 hasConceptScore W3157164906C2779548794 @default.
• W3157164906 hasConceptScore W3157164906C2780651595 @default.
• W3157164906 hasConceptScore W3157164906C2780690907 @default.
• W3157164906 hasConceptScore W3157164906C2780917455 @default.
• W3157164906 hasConceptScore W3157164906C86803240 @default.
• W3157164906 hasConceptScore W3157164906C89423630 @default.
• W3157164906 hasIssue "3" @default.
• W3157164906 hasLocation W31571649061 @default.
• W3157164906 hasLocation W31571649062 @default.
• W3157164906 hasLocation W31571649063 @default.
• W3157164906 hasLocation W31571649064 @default.
• W3157164906 hasOpenAccess W3157164906 @default.
• W3157164906 hasPrimaryLocation W31571649061 @default.
• W3157164906 hasRelatedWork W1801898498 @default.
• W3157164906 hasRelatedWork W1987805284 @default.
• W3157164906 hasRelatedWork W2045005302 @default.
• W3157164906 hasRelatedWork W2071694972 @default.
• W3157164906 hasRelatedWork W2126617328 @default.
• W3157164906 hasRelatedWork W2132357202 @default.

• next