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• W3157167130 endingPage "130063" @default.
• W3157167130 startingPage "130063" @default.
• W3157167130 abstract "• A ratiometric near-infrared fluorescent probe ( CX-MTC ) was developed for HOCl. • CX-MTC with a large peak-to-peak separation of 140 nm can avoid the crosstalk of excitation and emission signals. • CX-MTC exhibits excellent selectivity, sensitivity, low cytotoxicity, and photostability. • Imaging HOCl in PC 12 cells, living zebrafish and wound of diabetic mice was achieved with CX-MTC . Diabetes, a kind of metabolic disease with characteristics of chronic hyperglycemia, can trigger a series of complications. Among them, wound healing prolonging is one of the manifestations of complications. Hypochlorous acid (HOCl) is a ubiquitous reactive oxygen species (ROS) that plays a vital role in inflammatory response and has been considered as a biomarker for monitoring a wound healing process. Herein, a ratiometric near-infrared (NIR) fluorescent probe, CX-MTC , was synthesized and applied for monitoring HOCl. CX-MTC possesses a simple structure and can be easy synthesized. The probe shows itself emission at 525 nm, a new emission at 665 nm is observed after the reaction with HOCl with a large emission shift of 140 nm. CX-MTC provides excellent selectivity and high sensitivity towards HOCl with 63-fold fluorescence intensity ratio enhancement. The probe can be used for monitoring HOCl in cells. Moreover, CX-MTC was successfully used for imaging HOCl in OGD/R cell model. It is also the first fluorescent probe for HOCl detection in diabetic wound healing process, which will be a potentially useful strategy for clinical assay." @default.
• W3157167130 created "2021-05-10" @default.
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• W3157167130 date "2021-09-01" @default.
• W3157167130 modified "2023-10-18" @default.
• W3157167130 title "A ratiometric near-infrared fluorescent probe with a large emission peak shift for sensing and imaging hypochlorous acid" @default.
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• W3157167130 doi "https://doi.org/10.1016/j.snb.2021.130063" @default.
• W3157167130 hasPublicationYear "2021" @default.
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