FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157189207> ?p ?o ?g. }

• W3157189207 abstract "Nowadays, metabolic syndromes are emerging as global epidemics, whose incidence are increasing annually. However, the efficacy of therapy does not increase proportionately with the increased morbidity. Type 2 diabetes mellitus (T2DM) and non‑alcoholic fatty liver disease (NAFLD) are two common metabolic syndromes that are closely associated. The pathogenic mechanisms of T2DM and NAFLD have been studied, and it was revealed that insulin resistance, hyperglycemia, hepatic lipid accumulation and inflammation markedly contribute to the development of these two diseases. The 2‑series prostaglandins (PGs), a subgroup of eicosanoids, including PGD2, PGE2, PGF2α and PGI2, are converted from arachidonic acid catalyzed by the rate‑limiting enzymes cyclooxygenases (COXs). Considering their wide distribution in almost every tissue, 2‑series PG pathways exert complex and interlinked effects in mediating pancreatic β‑cell function and proliferation, insulin sensitivity, fat accumulation and lipolysis, as well as inflammatory processes. Previous studies have revealed that metabolic disturbances, such as hyperglycemia and hyperlipidemia, can be improved by treatment with COX inhibitors. At present, an accumulating number of studies have focused on the roles of 2‑series PGs and their metabolites in the pathogenesis of metabolic syndromes, particularly T2DM and NAFLD. In the present review, the role of 2‑series PGs in the highly intertwined pathogenic mechanisms of T2DM and NAFLD was discussed, and important therapeutic strategies based on targeting 2‑series PG pathways in T2DM and NAFLD treatment were provided." @default.
• W3157189207 created "2021-05-10" @default.
• W3157189207 creator A5031044964 @default.
• W3157189207 creator A5035149095 @default.
• W3157189207 creator A5073659985 @default.
• W3157189207 date "2021-04-26" @default.
• W3157189207 modified "2023-10-15" @default.
• W3157189207 title "Role of 2‑series prostaglandins in the pathogenesis of type 2 diabetes mellitus and non‑alcoholic fatty liver disease (Review)" @default.
• W3157189207 cites W1520844018 @default.
• W3157189207 cites W1534360145 @default.
• W3157189207 cites W1570190951 @default.
• W3157189207 cites W170527024 @default.
• W3157189207 cites W1757170915 @default.
• W3157189207 cites W1868946762 @default.
• W3157189207 cites W1872791853 @default.
• W3157189207 cites W1876860572 @default.
• W3157189207 cites W1884174564 @default.
• W3157189207 cites W189701252 @default.
• W3157189207 cites W1901225590 @default.
• W3157189207 cites W1924084714 @default.
• W3157189207 cites W1942040918 @default.
• W3157189207 cites W1943599856 @default.
• W3157189207 cites W1967057630 @default.
• W3157189207 cites W1967932879 @default.
• W3157189207 cites W1969295126 @default.
• W3157189207 cites W1970653898 @default.
• W3157189207 cites W1971120127 @default.
• W3157189207 cites W1974033843 @default.
• W3157189207 cites W1977425580 @default.
• W3157189207 cites W1979165975 @default.
• W3157189207 cites W1981456793 @default.
• W3157189207 cites W1984251611 @default.
• W3157189207 cites W1985929369 @default.
• W3157189207 cites W1986756809 @default.
• W3157189207 cites W1987840126 @default.
• W3157189207 cites W1991401793 @default.
• W3157189207 cites W1993959456 @default.
• W3157189207 cites W1994496611 @default.
• W3157189207 cites W1996168135 @default.
• W3157189207 cites W1996559225 @default.
• W3157189207 cites W1998370769 @default.
• W3157189207 cites W2002024495 @default.
• W3157189207 cites W2003885135 @default.
• W3157189207 cites W2005119615 @default.
• W3157189207 cites W2005674716 @default.
• W3157189207 cites W2008869160 @default.
• W3157189207 cites W2009509125 @default.
• W3157189207 cites W2010184926 @default.
• W3157189207 cites W2011499493 @default.
• W3157189207 cites W2016617561 @default.
• W3157189207 cites W2018135697 @default.
• W3157189207 cites W2020252055 @default.
• W3157189207 cites W2030666214 @default.
• W3157189207 cites W2033050749 @default.
• W3157189207 cites W2034946303 @default.
• W3157189207 cites W2035657846 @default.
• W3157189207 cites W2036409621 @default.
• W3157189207 cites W2037737533 @default.
• W3157189207 cites W2042362312 @default.
• W3157189207 cites W2045672949 @default.
• W3157189207 cites W2049628560 @default.
• W3157189207 cites W2050717908 @default.
• W3157189207 cites W2052692419 @default.
• W3157189207 cites W2052763780 @default.
• W3157189207 cites W2055333400 @default.
• W3157189207 cites W2057605095 @default.
• W3157189207 cites W2060388798 @default.
• W3157189207 cites W2061371967 @default.
• W3157189207 cites W2065543070 @default.
• W3157189207 cites W2072185334 @default.
• W3157189207 cites W2072840451 @default.
• W3157189207 cites W2074913439 @default.
• W3157189207 cites W2077149049 @default.
• W3157189207 cites W2077968457 @default.
• W3157189207 cites W2078162773 @default.
• W3157189207 cites W2081521523 @default.
• W3157189207 cites W2082464271 @default.
• W3157189207 cites W2083603805 @default.
• W3157189207 cites W2083748640 @default.
• W3157189207 cites W2089369126 @default.
• W3157189207 cites W2090130212 @default.
• W3157189207 cites W2090697965 @default.
• W3157189207 cites W2092695592 @default.
• W3157189207 cites W2095205890 @default.
• W3157189207 cites W2096098978 @default.
• W3157189207 cites W2097688893 @default.
• W3157189207 cites W2098344946 @default.
• W3157189207 cites W2100171908 @default.
• W3157189207 cites W2103567384 @default.
• W3157189207 cites W2104395968 @default.
• W3157189207 cites W2108462699 @default.
• W3157189207 cites W2109796699 @default.
• W3157189207 cites W2110034138 @default.
• W3157189207 cites W2110338837 @default.
• W3157189207 cites W2110872329 @default.
• W3157189207 cites W2111307666 @default.
• W3157189207 cites W2113184924 @default.
• W3157189207 cites W2113290184 @default.
• W3157189207 cites W2113544353 @default.
• W3157189207 cites W2117121624 @default.

• next