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- W3157195836 abstract "L-tryptophan (Trp) has been documented to aid sleep, but a systematic compilation of its effect on sleep quality is still limited.We assessed the effect of Trp supplementation on sleep quality via meta-analysis and meta-regression. The effects of daily Trp dose (<1 g and ≥1 g) were also assessed.A database search was done in PubMed, Medline (Ovid), Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Cochrane and a total of 18 articles were collected.Extracted data from 4 articles were also analyzed using random-effect meta-analysis and meta-regression. Standardized mean difference (SMD) was used in meta-analysis.Results from the study suggested that Trp supplementation can shorten wake after sleep onset (-81.03 min/g, P = 0.017; SMD, -1.08 min [95%CI, -1.89 to -0.28]). In addition, the group receiving ≥1 g Trp supplementation had a shorter wake after sleep onset than the group with Trp < 1g supplementation (Trp <1 g vs Trp ≥1 g: 56.55 vs 28.91 min; P = 0.001). However, Trp supplementation did not affect other sleep components.Trp supplementation, especially at ≥1 g can help improve sleep quality." @default.
- W3157195836 created "2021-05-10" @default.
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- W3157195836 date "2021-05-03" @default.
- W3157195836 modified "2023-10-16" @default.
- W3157195836 title "The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression" @default.
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- W3157195836 doi "https://doi.org/10.1093/nutrit/nuab027" @default.
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