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- W3157196261 abstract "A novel combination therapy for the treatment of gastric cancers has been established using two or more medications with a wide range of mode of actions. The effectiveness of this hybrid drug delivery mechanism involving irinotecan (SN-38) and 5-fluorouracil (5FU) was improved based on their potent anti-tumor capacity, which increased the anticancer property of gastric cells through stabilizing the tumor microenvironment. The encapsulation of SN-38 and 5FU anticancer drugs co-loaded in polyethylene glycol (PEG) and polylactide-co-glycolide (PLGA) nanoparticles (NPs) are incompetent owing to the inadequacy of the dual anticancer drugs SN-38 and 5FU encapsulated in polymeric biodegradable nanoparticles. Transmission microscopy (TEM) was used to examine the morphology of [email protected], [email protected], and [email protected], and the structure and size of these nanoparticles. Furthermore, the stability of these nanoparticles was assessed using dynamic light scattering (DLS). [email protected] also induced in vitro apoptosis of human gastric cells, such as NCI-N87 and SGC-791. Morphological shifts and cell death were detected using various biochemical staining, such as Calcein+/PI and Hoechst staining. Additionally, the mechanistic investigation of cell death was verified using flow cytometry in Annex V-FITC. Altogether, this dual drug delivery approach indicates that [email protected] might be used as a potential tool to improve the effectiveness of gastric cancer therapy." @default.
- W3157196261 created "2021-05-10" @default.
- W3157196261 creator A5047518415 @default.
- W3157196261 creator A5075864218 @default.
- W3157196261 date "2021-07-01" @default.
- W3157196261 modified "2023-09-30" @default.
- W3157196261 title "Synergic fabrication of combination therapy of Irinotecan and 5-Fluorouracil encapsulated polymeric nanoparticles for the treatment of gastric cancer therapy" @default.
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- W3157196261 doi "https://doi.org/10.1016/j.procbio.2021.04.008" @default.
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