FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157198712> ?p ?o ?g. }

• W3157198712 abstract "Abstract Placental vascular gene networks in mammals have been largely unexplored due to a lack of well validated molecular markers to identify them. This is required to study how they form in development, and how they are impacted by embryonic or maternal defects, which in-turn adversely affects the forming heart and vasculature. Such defects are known to be a consequence of maternal iron deficiency (ID), the most common nutrient deficiency world-wide. Here we employed marker analysis to characterise the arterial/arteriole and venous/venule endothelial cells (ECs) during normal placental development, and in the context of maternal ID. We reveal for the first time that placental ECs are unique compared with their embryonic counterparts. In the developing embryo, arterial ECs express Neuropilin1 ( Nrp1 ), Delta-like ligand 4 ( Dll4 ) and Notch1 , while developing venous ECs express Neuropilin2 ( Nrp2 ), Apj (Aplnr) and Ephrinb4 (Ephb4) . However, in the E15.5 placenta, Nrp1 and Notch1 were restricted to arteries, but not continuing arteriole ECs. The arterial tree exclusively expressed Dll4. Nrp2 showed pan-EC expression at E15.5, while Ephb4 was not present at this stage. However, we found the placental venous vascular tree could be distinguished from the arterial tree by high versus low Endomucin (EMCN) and Apj (Aplnr) expression respectively. Using EMCN, we reveal that the placental arterial, but not venous, vascular tree is adversely impacted by maternal ID, with reduced area, total length and number of junctions of all vessels without affecting the EMCN high vessels. Defects to the embryonic cardiovascular system can therefore have a significant impact on blood flow delivery and expansion of the placental arterial tree." @default.
• W3157198712 created "2021-05-10" @default.
• W3157198712 creator A5000041035 @default.
• W3157198712 creator A5002366090 @default.
• W3157198712 creator A5005708387 @default.
• W3157198712 creator A5012846561 @default.
• W3157198712 creator A5019090711 @default.
• W3157198712 creator A5025312610 @default.
• W3157198712 creator A5033154371 @default.
• W3157198712 creator A5034178101 @default.
• W3157198712 creator A5072518509 @default.
• W3157198712 creator A5077567786 @default.
• W3157198712 creator A5081557864 @default.
• W3157198712 creator A5083098512 @default.
• W3157198712 date "2021-05-06" @default.
• W3157198712 modified "2023-09-27" @default.
• W3157198712 title "Maternal iron deficiency impacts the placental arterial network" @default.
• W3157198712 cites W1964018614 @default.
• W3157198712 cites W1966000642 @default.
• W3157198712 cites W1969772038 @default.
• W3157198712 cites W1973096186 @default.
• W3157198712 cites W1974444855 @default.
• W3157198712 cites W1975184295 @default.
• W3157198712 cites W1981272936 @default.
• W3157198712 cites W1982434780 @default.
• W3157198712 cites W1984066122 @default.
• W3157198712 cites W1997508706 @default.
• W3157198712 cites W2030918859 @default.
• W3157198712 cites W2032262970 @default.
• W3157198712 cites W2035595755 @default.
• W3157198712 cites W2056916102 @default.
• W3157198712 cites W2061945394 @default.
• W3157198712 cites W2076583198 @default.
• W3157198712 cites W2094993899 @default.
• W3157198712 cites W2095315676 @default.
• W3157198712 cites W2098209538 @default.
• W3157198712 cites W2104135721 @default.
• W3157198712 cites W2106632025 @default.
• W3157198712 cites W2111920387 @default.
• W3157198712 cites W2128295200 @default.
• W3157198712 cites W2136479099 @default.
• W3157198712 cites W2152460775 @default.
• W3157198712 cites W2162544653 @default.
• W3157198712 cites W2166709616 @default.
• W3157198712 cites W2168479571 @default.
• W3157198712 cites W2265799297 @default.
• W3157198712 cites W2345281341 @default.
• W3157198712 cites W2358864432 @default.
• W3157198712 cites W2397417653 @default.
• W3157198712 cites W2505865716 @default.
• W3157198712 cites W2531007892 @default.
• W3157198712 cites W2551236604 @default.
• W3157198712 cites W2605801458 @default.
• W3157198712 cites W2620973972 @default.
• W3157198712 cites W2625982705 @default.
• W3157198712 cites W2728308062 @default.
• W3157198712 cites W2742785308 @default.
• W3157198712 cites W2750404716 @default.
• W3157198712 cites W2751254973 @default.
• W3157198712 cites W2753088052 @default.
• W3157198712 cites W2789302016 @default.
• W3157198712 cites W2802724612 @default.
• W3157198712 cites W2808147159 @default.
• W3157198712 cites W2810958966 @default.
• W3157198712 cites W2900916100 @default.
• W3157198712 cites W2962057213 @default.
• W3157198712 cites W3015633884 @default.
• W3157198712 cites W3046776136 @default.
• W3157198712 cites W3048244488 @default.
• W3157198712 cites W3083194833 @default.
• W3157198712 cites W3099364311 @default.
• W3157198712 cites W4236198398 @default.
• W3157198712 doi "https://doi.org/10.1101/2021.05.06.442902" @default.
• W3157198712 hasPublicationYear "2021" @default.
• W3157198712 type Work @default.
• W3157198712 sameAs 3157198712 @default.
• W3157198712 citedByCount "0" @default.
• W3157198712 crossrefType "posted-content" @default.
• W3157198712 hasAuthorship W3157198712A5000041035 @default.
• W3157198712 hasAuthorship W3157198712A5002366090 @default.
• W3157198712 hasAuthorship W3157198712A5005708387 @default.
• W3157198712 hasAuthorship W3157198712A5012846561 @default.
• W3157198712 hasAuthorship W3157198712A5019090711 @default.
• W3157198712 hasAuthorship W3157198712A5025312610 @default.
• W3157198712 hasAuthorship W3157198712A5033154371 @default.
• W3157198712 hasAuthorship W3157198712A5034178101 @default.
• W3157198712 hasAuthorship W3157198712A5072518509 @default.
• W3157198712 hasAuthorship W3157198712A5077567786 @default.
• W3157198712 hasAuthorship W3157198712A5081557864 @default.
• W3157198712 hasAuthorship W3157198712A5083098512 @default.
• W3157198712 hasBestOaLocation W31571987121 @default.
• W3157198712 hasConcept C104317684 @default.
• W3157198712 hasConcept C105702510 @default.
• W3157198712 hasConcept C123012128 @default.
• W3157198712 hasConcept C126322002 @default.
• W3157198712 hasConcept C134018914 @default.
• W3157198712 hasConcept C145103041 @default.
• W3157198712 hasConcept C151730666 @default.
• W3157198712 hasConcept C167734588 @default.
• W3157198712 hasConcept C172680121 @default.

• next