Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157208145> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3157208145 endingPage "1806" @default.
- W3157208145 startingPage "1801" @default.
- W3157208145 abstract "Introduction: Increased circulating androgens are key to the multifactorial pathogenesis of acne. Clascoterone is the first topical androgen antagonist developed to treat acne in both male and female patients and the first such agent to receive U.S. Food and Drug Administration (FDA) approval for treatment of acne. Androgens directly stimulate sebaceous gland growth and increased sebum production, creating a nourishing medium in which anaerobic Cutibacterium acnes (C. acnes) bacteria flourish. Androgens may directly contribute to inflammation in the sebaceous gland.Areas covered: In this review, the author assesses clascoterone’s potential role in the management of acne. With a 4-ring backbone identical to dihydrotestosterone (DHT) and spironolactone, topically applied clascoterone binds androgen receptors (ARs) in the sebaceous glands and hair follicles, interfering with the pathogenesis of acne and reducing acne lesions with no reported systemic effects.Expert opinion: Phase III study results confirmed the safety and efficacy of topical clascoterone for acne, with considerable reductions in absolute non-inflammatory and inflammatory lesion counts at week 12. The approval of a first-in-class topical androgen antagonist is indeed a ‘game-changer’ for acne management. This topical agent is expected to be quickly adopted in clinical practice, likely within combination regiments, yet to be formally evaluated." @default.
- W3157208145 created "2021-05-10" @default.
- W3157208145 creator A5058903008 @default.
- W3157208145 date "2021-04-27" @default.
- W3157208145 modified "2023-10-06" @default.
- W3157208145 title "Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist" @default.
- W3157208145 cites W1980808116 @default.
- W3157208145 cites W2016272843 @default.
- W3157208145 cites W2165062882 @default.
- W3157208145 cites W2276726626 @default.
- W3157208145 cites W2542726711 @default.
- W3157208145 cites W2596666254 @default.
- W3157208145 cites W2598207101 @default.
- W3157208145 cites W2748083951 @default.
- W3157208145 cites W2790700466 @default.
- W3157208145 cites W2888626625 @default.
- W3157208145 cites W2907084866 @default.
- W3157208145 cites W2912896508 @default.
- W3157208145 cites W2996940994 @default.
- W3157208145 cites W3007843018 @default.
- W3157208145 cites W3016566360 @default.
- W3157208145 cites W3048735500 @default.
- W3157208145 doi "https://doi.org/10.1080/14656566.2021.1918100" @default.
- W3157208145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33906537" @default.
- W3157208145 hasPublicationYear "2021" @default.
- W3157208145 type Work @default.
- W3157208145 sameAs 3157208145 @default.
- W3157208145 citedByCount "7" @default.
- W3157208145 countsByYear W31572081452021 @default.
- W3157208145 countsByYear W31572081452022 @default.
- W3157208145 countsByYear W31572081452023 @default.
- W3157208145 crossrefType "journal-article" @default.
- W3157208145 hasAuthorship W3157208145A5058903008 @default.
- W3157208145 hasConcept C121608353 @default.
- W3157208145 hasConcept C126322002 @default.
- W3157208145 hasConcept C134018914 @default.
- W3157208145 hasConcept C16005928 @default.
- W3157208145 hasConcept C170493617 @default.
- W3157208145 hasConcept C2776379505 @default.
- W3157208145 hasConcept C2776885963 @default.
- W3157208145 hasConcept C2777363609 @default.
- W3157208145 hasConcept C2777673923 @default.
- W3157208145 hasConcept C2777911890 @default.
- W3157208145 hasConcept C2778198053 @default.
- W3157208145 hasConcept C2779279991 @default.
- W3157208145 hasConcept C2780192828 @default.
- W3157208145 hasConcept C2780942790 @default.
- W3157208145 hasConcept C61367390 @default.
- W3157208145 hasConcept C71315377 @default.
- W3157208145 hasConcept C71924100 @default.
- W3157208145 hasConcept C98274493 @default.
- W3157208145 hasConceptScore W3157208145C121608353 @default.
- W3157208145 hasConceptScore W3157208145C126322002 @default.
- W3157208145 hasConceptScore W3157208145C134018914 @default.
- W3157208145 hasConceptScore W3157208145C16005928 @default.
- W3157208145 hasConceptScore W3157208145C170493617 @default.
- W3157208145 hasConceptScore W3157208145C2776379505 @default.
- W3157208145 hasConceptScore W3157208145C2776885963 @default.
- W3157208145 hasConceptScore W3157208145C2777363609 @default.
- W3157208145 hasConceptScore W3157208145C2777673923 @default.
- W3157208145 hasConceptScore W3157208145C2777911890 @default.
- W3157208145 hasConceptScore W3157208145C2778198053 @default.
- W3157208145 hasConceptScore W3157208145C2779279991 @default.
- W3157208145 hasConceptScore W3157208145C2780192828 @default.
- W3157208145 hasConceptScore W3157208145C2780942790 @default.
- W3157208145 hasConceptScore W3157208145C61367390 @default.
- W3157208145 hasConceptScore W3157208145C71315377 @default.
- W3157208145 hasConceptScore W3157208145C71924100 @default.
- W3157208145 hasConceptScore W3157208145C98274493 @default.
- W3157208145 hasIssue "13" @default.
- W3157208145 hasLocation W31572081451 @default.
- W3157208145 hasOpenAccess W3157208145 @default.
- W3157208145 hasPrimaryLocation W31572081451 @default.
- W3157208145 hasRelatedWork W1965833776 @default.
- W3157208145 hasRelatedWork W1979452793 @default.
- W3157208145 hasRelatedWork W1981433740 @default.
- W3157208145 hasRelatedWork W1986311037 @default.
- W3157208145 hasRelatedWork W2004261902 @default.
- W3157208145 hasRelatedWork W2083564258 @default.
- W3157208145 hasRelatedWork W2089368232 @default.
- W3157208145 hasRelatedWork W2103250319 @default.
- W3157208145 hasRelatedWork W2153400994 @default.
- W3157208145 hasRelatedWork W4386949010 @default.
- W3157208145 hasVolume "22" @default.
- W3157208145 isParatext "false" @default.
- W3157208145 isRetracted "false" @default.
- W3157208145 magId "3157208145" @default.
- W3157208145 workType "article" @default.