Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157209850> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3157209850 endingPage "2351" @default.
- W3157209850 startingPage "2342" @default.
- W3157209850 abstract "Acalabrutinib is a highly selective, potent, next-generation, covalent Bruton tyrosine kinase inhibitor with minimal off-target activity. Matching-adjusted indirect comparisons (MAICs) were performed to estimate the safety and efficacy of acalabrutinib compared to other targeted therapies for treatment-naïve patients with chronic lymphocytic leukemia (CLL). Individual patient data for acalabrutinib (ELEVATE-TN trial) were matched to aggregate baseline characteristics for comparators. After matching, acalabrutinib (with or without obinutuzumab) showed improved safety outcomes, except for increased risk of neutropenia (p < 0.001) for acalabrutinib plus obinutuzumab versus ibrutinib and increased risk of leukopenia (p < 0.05) for acalabrutinib (with or without obinutuzumab) versus venetoclax plus obinutuzumab. There was no statistically significant difference in progression-free survival between acalabrutinib (with or without obinutuzumab) and any of the comparators. This MAIC demonstrated a favorable safety profile for acalabrutinib-based therapy compared with other targeted therapies in treatment-naïve patients with CLL, without compromising efficacy." @default.
- W3157209850 created "2021-05-10" @default.
- W3157209850 creator A5022268863 @default.
- W3157209850 creator A5063755644 @default.
- W3157209850 creator A5066983414 @default.
- W3157209850 creator A5072081357 @default.
- W3157209850 creator A5079478435 @default.
- W3157209850 date "2021-05-06" @default.
- W3157209850 modified "2023-09-30" @default.
- W3157209850 title "Matching-adjusted indirect comparisons of safety and efficacy of acalabrutinib versus other targeted therapies in patients with treatment-naïve chronic lymphocytic leukemia" @default.
- W3157209850 cites W1931149717 @default.
- W3157209850 cites W1941121600 @default.
- W3157209850 cites W1982967337 @default.
- W3157209850 cites W2092901728 @default.
- W3157209850 cites W2120319857 @default.
- W3157209850 cites W2125776201 @default.
- W3157209850 cites W2233614027 @default.
- W3157209850 cites W2296618733 @default.
- W3157209850 cites W2323490326 @default.
- W3157209850 cites W2650689221 @default.
- W3157209850 cites W2705118184 @default.
- W3157209850 cites W2788803761 @default.
- W3157209850 cites W2790385276 @default.
- W3157209850 cites W2806627663 @default.
- W3157209850 cites W2883556053 @default.
- W3157209850 cites W2894684271 @default.
- W3157209850 cites W2902484351 @default.
- W3157209850 cites W2902706178 @default.
- W3157209850 cites W2948436219 @default.
- W3157209850 cites W2983390781 @default.
- W3157209850 cites W2987552010 @default.
- W3157209850 cites W2999980976 @default.
- W3157209850 cites W3016538158 @default.
- W3157209850 cites W3082591026 @default.
- W3157209850 cites W3092290441 @default.
- W3157209850 cites W4251009301 @default.
- W3157209850 doi "https://doi.org/10.1080/10428194.2021.1913144" @default.
- W3157209850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33955326" @default.
- W3157209850 hasPublicationYear "2021" @default.
- W3157209850 type Work @default.
- W3157209850 sameAs 3157209850 @default.
- W3157209850 citedByCount "7" @default.
- W3157209850 countsByYear W31572098502021 @default.
- W3157209850 countsByYear W31572098502022 @default.
- W3157209850 countsByYear W31572098502023 @default.
- W3157209850 crossrefType "journal-article" @default.
- W3157209850 hasAuthorship W3157209850A5022268863 @default.
- W3157209850 hasAuthorship W3157209850A5063755644 @default.
- W3157209850 hasAuthorship W3157209850A5066983414 @default.
- W3157209850 hasAuthorship W3157209850A5072081357 @default.
- W3157209850 hasAuthorship W3157209850A5079478435 @default.
- W3157209850 hasBestOaLocation W31572098501 @default.
- W3157209850 hasConcept C126322002 @default.
- W3157209850 hasConcept C143998085 @default.
- W3157209850 hasConcept C2777063308 @default.
- W3157209850 hasConcept C2777607594 @default.
- W3157209850 hasConcept C2777938653 @default.
- W3157209850 hasConcept C2778461978 @default.
- W3157209850 hasConcept C2779878957 @default.
- W3157209850 hasConcept C29730261 @default.
- W3157209850 hasConcept C71924100 @default.
- W3157209850 hasConcept C98274493 @default.
- W3157209850 hasConceptScore W3157209850C126322002 @default.
- W3157209850 hasConceptScore W3157209850C143998085 @default.
- W3157209850 hasConceptScore W3157209850C2777063308 @default.
- W3157209850 hasConceptScore W3157209850C2777607594 @default.
- W3157209850 hasConceptScore W3157209850C2777938653 @default.
- W3157209850 hasConceptScore W3157209850C2778461978 @default.
- W3157209850 hasConceptScore W3157209850C2779878957 @default.
- W3157209850 hasConceptScore W3157209850C29730261 @default.
- W3157209850 hasConceptScore W3157209850C71924100 @default.
- W3157209850 hasConceptScore W3157209850C98274493 @default.
- W3157209850 hasFunder F4320307770 @default.
- W3157209850 hasIssue "10" @default.
- W3157209850 hasLocation W31572098501 @default.
- W3157209850 hasLocation W31572098502 @default.
- W3157209850 hasOpenAccess W3157209850 @default.
- W3157209850 hasPrimaryLocation W31572098501 @default.
- W3157209850 hasRelatedWork W1809182350 @default.
- W3157209850 hasRelatedWork W2900694112 @default.
- W3157209850 hasRelatedWork W2904028717 @default.
- W3157209850 hasRelatedWork W2940552296 @default.
- W3157209850 hasRelatedWork W2952362276 @default.
- W3157209850 hasRelatedWork W2967600517 @default.
- W3157209850 hasRelatedWork W3020293355 @default.
- W3157209850 hasRelatedWork W3092128927 @default.
- W3157209850 hasRelatedWork W4210951503 @default.
- W3157209850 hasRelatedWork W4283518388 @default.
- W3157209850 hasVolume "62" @default.
- W3157209850 isParatext "false" @default.
- W3157209850 isRetracted "false" @default.
- W3157209850 magId "3157209850" @default.
- W3157209850 workType "article" @default.