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• W3157213020 abstract "We assessed in extremely preterm born (EPB) children whether secondary somatosensory cortex (SII) responses recorded with magnetoencephalography (MEG) at term-equivalent age (TEA) correlate with neurodevelopmental outcome at age 6 years. Secondly, we assessed whether SII responses differ between 6-year-old EPB and term-born (TB) children. 39 EPB children underwent MEG with tactile stimulation at TEA. At age 6 years, 32 EPB and 26 TB children underwent MEG including a sensorimotor task requiring attention and motor inhibition. SII responses to tactile stimulation were modeled with equivalent current dipoles. Neurological outcome, motor competence, and general cognitive ability were prospectively evaluated at age 6 years. Unilaterally absent SII response at TEA was associated with abnormal motor competence in 6-year-old EPB children (p = 0.03). At age 6 years, SII responses were bilaterally detectable in most EPB (88%) and TB (92%) children (group comparison, p = 0.69). Motor inhibition was associated with decreased SII peak latencies in TB children, but EPB children lacked this effect (p = 0.02). Unilateral absence of an SII response at TEA predicted poorer motor outcome in EPB children. Neurophysiological methods may provide new means for outcome prognostication in EPB children." @default.
• W3157213020 created "2021-05-10" @default.
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• W3157213020 date "2021-07-01" @default.
• W3157213020 modified "2023-09-23" @default.
• W3157213020 title "Secondary somatosensory cortex evoked responses and 6-year neurodevelopmental outcome in extremely preterm children" @default.
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• W3157213020 doi "https://doi.org/10.1016/j.clinph.2021.04.005" @default.
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