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• W3157227486 abstract "Emerging evidence has shown that aberrant expression of lncRNA-TP53TG1 plays important roles in various malignancies. However, the biological functions of lncRNA-TP53TG1 in hepatocarcinogenesis, as well as the underlying mechanisms, remain largely unknown. Here, we assessed whether lncRNA-TP53TG1 plays a key role in the progression of hepatocellular carcinoma (HCC). The expression of lncRNA-TP53TG1 was significantly decreased in HCC tissues and cells. Decreased expression of lncRNA-TP53TG1 was associated with aggressive clinical phenotypes and a poor prognosis. Ectopic expression of lncRNA-TP53TG1 inhibited hepatoma cell proliferation and migration in vitro and in vivo, whereas lncRNA-TP53TG1 knockdown exerted the opposite effects. Furthermore, lncRNA-TP53TG1 played an important role in slowing the epithelial-mesenchymal transition (EMT) process in HCC. Mechanistically, lncRNA-TP53TG1 physically interacted with PRDX4 and promoted its ubiquitin-mediated degradation, resulting in the inactivation of the WNT/β-catenin signaling pathway in hepatoma cells. Our findings demonstrate a novel mechanism by which lncRNA-TP53TG1 exerts its tumor-suppressive effects through the WNT/β-catenin signaling pathway in a PRDX4-mediated manner in HCC. Based on these results, lncRNA-TP53TG1 potentially represents a prognostic indicator and therapeutic target for patients with HCC. • Decreased expression of lncRNA-TP53TG1 was associated with aggressive clinical phenotypes and poor prognosis. • LncRNA-TP53TG1 inhibited hepatoma cell proliferation and migration in vitro and in vivo. • LncRNA-TP53TG1 inactivated WNT/β-catenin signaling pathway by interacting with PRDX4 in hepatoma cells. • LncRNA-TP53TG1 could serve as prognostic indicator and therapeutic target for patients with HCC." @default.
• W3157227486 created "2021-05-10" @default.
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• W3157227486 date "2021-08-01" @default.
• W3157227486 modified "2023-10-14" @default.
• W3157227486 title "Long noncoding RNA TP53TG1 suppresses the growth and metastasis of hepatocellular carcinoma by regulating the PRDX4/β-catenin pathway" @default.
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• W3157227486 doi "https://doi.org/10.1016/j.canlet.2021.04.022" @default.
• W3157227486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33957185" @default.
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