FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157236434> ?p ?o ?g. }

• W3157236434 abstract "Ca2+ signaling plays an essential role in T cell activation, which is a key step to start an adaptive immune response. During the transition from a quiescent to a fully activated state, Ca2+ microdomains characterized by reduced spatial and temporal extents are observed in the junctions between the plasma membrane (PM) and the endoplasmic reticulum (ER). Such Ca2+ responses can also occur in response to T cell adhesion to other cells or extracellular matrix proteins in otherwise unstimulated T cells. These non-TCR/CD3-dependent Ca2+ microdomains rely on d-myo-inositol 1,4,5-trisphosphate (IP3) signaling and subsequent store operated Ca2+ entry (SOCE) via the ORAI/STIM system. The detailed molecular mechanism of adhesion-dependent Ca2+ microdomain formation remains to be fully elucidated. We used mathematical modeling to investigate the spatiotemporal characteristics of T cell Ca2+ microdomains and their molecular regulators. We developed a reaction-diffusion model using COMSOL Multiphysics to describe the evolution of cytosolic and ER Ca2+ concentrations in a three-dimensional ER-PM junction. Equations are based on a previously proposed realistic description of the junction, which is extended to take into account IP3 receptors (IP3R) that are located next to the junction. The first model only considered the ORAI channels and the SERCA pumps. Taking into account the existence of preformed clusters of ORAI1 and STIM2, ORAI1 slightly opens in conditions of a full ER. These simulated Ca2+ microdomains are too small as compared to those observed in unstimulated T cells. When considering the opening of the IP3Rs located near the junction, the local depletion of ER Ca2+ allows for larger Ca2+ fluxes through the ORAI1 channels and hence larger local Ca2+ concentrations. Computational results moreover show that Ca2+ diffusion in the ER has a major impact on the Ca2+ changes in the junction, by affecting the local Ca2+ gradients in the sub-PM ER. Besides pointing out the likely involvement of the spontaneous openings of IP3Rs in the activation of SOCE in conditions of T cell adhesion prior to full activation, the model provides a tool to investigate how Ca2+ microdomains extent and interact in response to T cell receptor activation." @default.
• W3157236434 created "2021-05-10" @default.
• W3157236434 creator A5019932465 @default.
• W3157236434 creator A5028331931 @default.
• W3157236434 creator A5071751610 @default.
• W3157236434 date "2021-04-28" @default.
• W3157236434 modified "2023-10-10" @default.
• W3157236434 title "Three-Dimensional Model of Sub-Plasmalemmal Ca2+ Microdomains Evoked by the Interplay Between ORAI1 and InsP3 Receptors" @default.
• W3157236434 cites W1426006818 @default.
• W3157236434 cites W1572218605 @default.
• W3157236434 cites W1661017705 @default.
• W3157236434 cites W1973007456 @default.
• W3157236434 cites W1977068570 @default.
• W3157236434 cites W1984414750 @default.
• W3157236434 cites W1999195317 @default.
• W3157236434 cites W1999335128 @default.
• W3157236434 cites W2008245136 @default.
• W3157236434 cites W2011220586 @default.
• W3157236434 cites W2013802663 @default.
• W3157236434 cites W2019023589 @default.
• W3157236434 cites W2021984772 @default.
• W3157236434 cites W2035254857 @default.
• W3157236434 cites W2037231034 @default.
• W3157236434 cites W2042144124 @default.
• W3157236434 cites W2054071776 @default.
• W3157236434 cites W2054723193 @default.
• W3157236434 cites W2077731194 @default.
• W3157236434 cites W2091626869 @default.
• W3157236434 cites W2108183974 @default.
• W3157236434 cites W2118075556 @default.
• W3157236434 cites W2139125300 @default.
• W3157236434 cites W2141955111 @default.
• W3157236434 cites W2150942343 @default.
• W3157236434 cites W2151839418 @default.
• W3157236434 cites W2162909966 @default.
• W3157236434 cites W2164156889 @default.
• W3157236434 cites W2164819852 @default.
• W3157236434 cites W2169253528 @default.
• W3157236434 cites W2170641660 @default.
• W3157236434 cites W2185966115 @default.
• W3157236434 cites W2211664995 @default.
• W3157236434 cites W2465421754 @default.
• W3157236434 cites W2487752638 @default.
• W3157236434 cites W2555576147 @default.
• W3157236434 cites W2611384040 @default.
• W3157236434 cites W2767850668 @default.
• W3157236434 cites W2769116429 @default.
• W3157236434 cites W2796335226 @default.
• W3157236434 cites W2797009114 @default.
• W3157236434 cites W2904417695 @default.
• W3157236434 cites W2908770791 @default.
• W3157236434 cites W2912670376 @default.
• W3157236434 cites W2920743482 @default.
• W3157236434 cites W2963507068 @default.
• W3157236434 cites W2967980310 @default.
• W3157236434 cites W2976642807 @default.
• W3157236434 cites W3010008730 @default.
• W3157236434 cites W3024569254 @default.
• W3157236434 cites W3134190116 @default.
• W3157236434 doi "https://doi.org/10.3389/fimmu.2021.659790" @default.
• W3157236434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8113648" @default.
• W3157236434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33995380" @default.
• W3157236434 hasPublicationYear "2021" @default.
• W3157236434 type Work @default.
• W3157236434 sameAs 3157236434 @default.
• W3157236434 citedByCount "10" @default.
• W3157236434 countsByYear W31572364342021 @default.
• W3157236434 countsByYear W31572364342022 @default.
• W3157236434 countsByYear W31572364342023 @default.
• W3157236434 crossrefType "journal-article" @default.
• W3157236434 hasAuthorship W3157236434A5019932465 @default.
• W3157236434 hasAuthorship W3157236434A5028331931 @default.
• W3157236434 hasAuthorship W3157236434A5071751610 @default.
• W3157236434 hasBestOaLocation W31572364341 @default.
• W3157236434 hasConcept C12554922 @default.
• W3157236434 hasConcept C134088382 @default.
• W3157236434 hasConcept C158617107 @default.
• W3157236434 hasConcept C162740809 @default.
• W3157236434 hasConcept C181199279 @default.
• W3157236434 hasConcept C185592680 @default.
• W3157236434 hasConcept C19317047 @default.
• W3157236434 hasConcept C201571599 @default.
• W3157236434 hasConcept C203014093 @default.
• W3157236434 hasConcept C23265538 @default.
• W3157236434 hasConcept C2776090121 @default.
• W3157236434 hasConcept C2776610495 @default.
• W3157236434 hasConcept C2781414619 @default.
• W3157236434 hasConcept C41625074 @default.
• W3157236434 hasConcept C55493867 @default.
• W3157236434 hasConcept C62478195 @default.
• W3157236434 hasConcept C86803240 @default.
• W3157236434 hasConcept C8891405 @default.
• W3157236434 hasConcept C95444343 @default.
• W3157236434 hasConcept C98539663 @default.
• W3157236434 hasConceptScore W3157236434C12554922 @default.
• W3157236434 hasConceptScore W3157236434C134088382 @default.
• W3157236434 hasConceptScore W3157236434C158617107 @default.
• W3157236434 hasConceptScore W3157236434C162740809 @default.
• W3157236434 hasConceptScore W3157236434C181199279 @default.
• W3157236434 hasConceptScore W3157236434C185592680 @default.

• next