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- W3157236497 abstract "Facile fabrication of Fe-based nanotheranostic agents with the enhanced Chemodynamic therapy (CDT) effect and multiple functions is important for oncotherapy. In this report, [email protected]xOy core-shell nanoparticles ([email protected]xOy NPs, [email protected]xOy NPs, [email protected]xOy NPs and [email protected]xOy NPs) are one-pot constructed by a simply redox self-assembly strategy. As a typical example, [email protected]xOy NPs are applied for oncotherapy. Compared to their crystalline counterparts (e.g., [email protected]2O3 nanocrystals (NCs)), [email protected]xOy NPs with the metastable FexOy shell can be activated by a small amount of NaBH4 to obviously enhance the production of ·OH in subsequent Fenton reaction (these activated products are termed as [email protected]xOy NPs). In addition, a favorable photothermal effect (63.5% photothermal conversion efficiency) of [email protected]xOy NPs can further promote the ·OH generation. Moreover, [email protected]xOy NPs also show a pH-responsive T1-weighted MRI contrast property, CT imaging capacity and the function of regulating tumor microenvironment. This work presents an attractive route to prepare versatile nanotheranostic agents." @default.
- W3157236497 created "2021-05-10" @default.
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- W3157236497 date "2021-07-01" @default.
- W3157236497 modified "2023-10-17" @default.
- W3157236497 title "One-pot synthesis of AuPd@FexOy nanoagent with the activable Fe species for enhanced Chemodynamic-photothermal synergetic therapy" @default.
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- W3157236497 doi "https://doi.org/10.1016/j.biomaterials.2021.120821" @default.
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