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• W3157240361 abstract "Mammals can produce nine kinds of arginine methylation enzymes that can be divided into three types (I, II, and III) according to their catalytic activity. Arginine methyltransferase 1 (PRMT1), as the first discovered arginine methyltransferase type I, has been reported to be involved in cell signal transduction, DNA damage repair, RNA transcription and other processes. Its imbalance or abnormal expression is also involved in cancer metastasis. PRMT1 is highly expressed in gastrointestinal tumors and promotes tumor biomarkers expression, chemotherapy resistance and tumorigenicity to promote cancer progression, while downregulation of PRMT1 expression can inhibit the migration and invasion of related tumor cells or promote tumor cells apoptosis and inhibit the progression of cancer. Therefore, PRMT1 may be a cancer therapeutic target. In this paper, arginine methylase 1 expression in various types of gastrointestinal tumors, the tumorigenic mechanism and the role of PRMT1 in tumorigenesis and development were reviewed." @default.
• W3157240361 created "2021-05-10" @default.
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• W3157240361 date "2021-06-30" @default.
• W3157240361 modified "2023-09-27" @default.
• W3157240361 title "The Role of Protein Arginine Methyltransferase 1 in Gastrointestinal Cancers" @default.
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• W3157240361 doi "https://doi.org/10.5772/intechopen.96197" @default.
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