FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157248895> ?p ?o ?g. }

• W3157248895 endingPage "175883592110069" @default.
• W3157248895 startingPage "175883592110069" @default.
• W3157248895 abstract "Lung adenocarcinomas exhibit various patterns of genomic alterations. During the development of this cancer, KRAS serves as a driver oncogene with a relatively high mutational frequency. Emerging data suggest that lung adenocarcinomas with KRAS mutations can show enhanced PD-L1 expression and additional somatic mutations, thus linking the prospect of applying immune checkpoint blockade therapy to this disease. However, the responses of KRAS-mutant lung adenocarcinomas to this therapy are distinct, which is largely attributed to the heterogeneity in the tumoral immune milieus. Recently, it was revealed that KRAS-mutant lung adenocarcinomas simultaneously expressing either a LKB1 or TP53 mutation typically have different immune profiles of their tumours: tumours with a KRAS/TP53 co-mutation generally present with a significant upregulation of PD-L1 expression and tumoricidal T-cell accumulation, and those with a KRAS/LKB1 co-mutation are frequently negative for PD-L1 expression and have few tumoricidal immune infiltrates. In this regard, interrogating TP53 or LKB1 mutation in addition to PD-L1 expression will be promising in guiding clinical use of immune checkpoint blockade therapy for KRAS-mutant lung adenocarcinomas." @default.
• W3157248895 created "2021-05-10" @default.
• W3157248895 creator A5054055653 @default.
• W3157248895 creator A5066707366 @default.
• W3157248895 creator A5089839520 @default.
• W3157248895 date "2021-01-01" @default.
• W3157248895 modified "2023-09-27" @default.
• W3157248895 title "<i>KRAS/LKB1</i> and <i>KRAS/TP53</i> co-mutations create divergent immune signatures in lung adenocarcinomas" @default.
• W3157248895 cites W1904885158 @default.
• W3157248895 cites W1973748124 @default.
• W3157248895 cites W1976566249 @default.
• W3157248895 cites W1992724001 @default.
• W3157248895 cites W1996563138 @default.
• W3157248895 cites W2031570350 @default.
• W3157248895 cites W2044433401 @default.
• W3157248895 cites W2044874695 @default.
• W3157248895 cites W2081990599 @default.
• W3157248895 cites W2100039832 @default.
• W3157248895 cites W2114408324 @default.
• W3157248895 cites W2115359326 @default.
• W3157248895 cites W2129590156 @default.
• W3157248895 cites W2134370756 @default.
• W3157248895 cites W2134964552 @default.
• W3157248895 cites W2135617839 @default.
• W3157248895 cites W2145411470 @default.
• W3157248895 cites W2163798887 @default.
• W3157248895 cites W2166923287 @default.
• W3157248895 cites W2172561271 @default.
• W3157248895 cites W2180481128 @default.
• W3157248895 cites W2188278098 @default.
• W3157248895 cites W2273119405 @default.
• W3157248895 cites W2284388501 @default.
• W3157248895 cites W2323356988 @default.
• W3157248895 cites W2342639474 @default.
• W3157248895 cites W2474854223 @default.
• W3157248895 cites W2544109448 @default.
• W3157248895 cites W2561459036 @default.
• W3157248895 cites W2608102145 @default.
• W3157248895 cites W2613174768 @default.
• W3157248895 cites W2764232556 @default.
• W3157248895 cites W2783677708 @default.
• W3157248895 cites W2783897381 @default.
• W3157248895 cites W2790362775 @default.
• W3157248895 cites W2790695210 @default.
• W3157248895 cites W2791328450 @default.
• W3157248895 cites W2795913084 @default.
• W3157248895 cites W2803397860 @default.
• W3157248895 cites W2804812017 @default.
• W3157248895 cites W2805354595 @default.
• W3157248895 cites W2885810182 @default.
• W3157248895 cites W2891146170 @default.
• W3157248895 cites W2892640821 @default.
• W3157248895 cites W2893631054 @default.
• W3157248895 cites W2894717949 @default.
• W3157248895 cites W2895058922 @default.
• W3157248895 cites W2902276046 @default.
• W3157248895 cites W2903663678 @default.
• W3157248895 cites W2910245285 @default.
• W3157248895 cites W2913235593 @default.
• W3157248895 cites W2925446385 @default.
• W3157248895 cites W2936661866 @default.
• W3157248895 cites W2943618951 @default.
• W3157248895 cites W2945039203 @default.
• W3157248895 cites W2946166987 @default.
• W3157248895 cites W2972329402 @default.
• W3157248895 cites W2982321167 @default.
• W3157248895 cites W2982649277 @default.
• W3157248895 cites W2988286834 @default.
• W3157248895 cites W2998386687 @default.
• W3157248895 cites W3007391700 @default.
• W3157248895 cites W3009099064 @default.
• W3157248895 cites W3017125932 @default.
• W3157248895 cites W3033016612 @default.
• W3157248895 cites W3041116333 @default.
• W3157248895 doi "https://doi.org/10.1177/17588359211006950" @default.
• W3157248895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8072935" @default.
• W3157248895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33995590" @default.
• W3157248895 hasPublicationYear "2021" @default.
• W3157248895 type Work @default.
• W3157248895 sameAs 3157248895 @default.
• W3157248895 citedByCount "26" @default.
• W3157248895 countsByYear W31572488952021 @default.
• W3157248895 countsByYear W31572488952022 @default.
• W3157248895 countsByYear W31572488952023 @default.
• W3157248895 crossrefType "journal-article" @default.
• W3157248895 hasAuthorship W3157248895A5054055653 @default.
• W3157248895 hasAuthorship W3157248895A5066707366 @default.
• W3157248895 hasAuthorship W3157248895A5089839520 @default.
• W3157248895 hasBestOaLocation W31572488951 @default.
• W3157248895 hasConcept C104317684 @default.
• W3157248895 hasConcept C121608353 @default.
• W3157248895 hasConcept C126322002 @default.
• W3157248895 hasConcept C143998085 @default.
• W3157248895 hasConcept C170493617 @default.
• W3157248895 hasConcept C203014093 @default.
• W3157248895 hasConcept C2776256026 @default.
• W3157248895 hasConcept C2777701055 @default.
• W3157248895 hasConcept C2778468042 @default.

• next