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- W3157258766 abstract "Angiotensin II (Ang II) regulates colon contraction, acting not only directly on smooth muscle but also indirectly, interfering with myenteric neuromodulation mediated by the activation of AT1 /AT2 receptors. In this article, we aimed to explore which mediators and cells were involved in Ang II-mediated colonic contraction in the TNBS-induced rat model of colitis. The contractile responses to Ang II were evaluated in distinct regions of the colon of control animals or animals with colitis in the absence and presence of different antagonists/inhibitors. Endogenous levels of Ang II in the colon were assessed by ELISA and the number of AT1/AT2 receptors by qPCR. Ang II caused AT1 receptor-mediated colonic contraction that was markedly decreased along the colons of TNBS-induced rats, consistent with reduced AT1 mRNA expression. However, the effect mediated by Ang II is much more intricate, involving (in addition to smooth muscle cells and nerve terminals) ICC and EGC, which communicate by releasing ACh and NO in a complex mechanism that changes colitis, unveiling new therapeutic targets." @default.
- W3157258766 created "2021-05-10" @default.
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- W3157258766 date "2021-05-03" @default.
- W3157258766 modified "2023-10-17" @default.
- W3157258766 title "Interaction between the Renin–Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis" @default.
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- W3157258766 cites W1775749144 @default.
- W3157258766 cites W1950141864 @default.
- W3157258766 cites W1954339858 @default.
- W3157258766 cites W1966339428 @default.
- W3157258766 cites W1966686940 @default.
- W3157258766 cites W1970819426 @default.
- W3157258766 cites W1975693733 @default.
- W3157258766 cites W1977216511 @default.
- W3157258766 cites W1977634558 @default.
- W3157258766 cites W1981367331 @default.
- W3157258766 cites W1988964423 @default.
- W3157258766 cites W1990965114 @default.
- W3157258766 cites W1992711677 @default.
- W3157258766 cites W1995788380 @default.
- W3157258766 cites W1998386546 @default.
- W3157258766 cites W2008956690 @default.
- W3157258766 cites W2015351306 @default.
- W3157258766 cites W2018932324 @default.
- W3157258766 cites W2025065287 @default.
- W3157258766 cites W2028423058 @default.
- W3157258766 cites W2028439883 @default.
- W3157258766 cites W2028631678 @default.
- W3157258766 cites W2029532012 @default.
- W3157258766 cites W2035858291 @default.
- W3157258766 cites W2039737984 @default.
- W3157258766 cites W2041105413 @default.
- W3157258766 cites W2046984200 @default.
- W3157258766 cites W2051203060 @default.
- W3157258766 cites W2051962915 @default.
- W3157258766 cites W2053977471 @default.
- W3157258766 cites W2056410831 @default.
- W3157258766 cites W2063503631 @default.
- W3157258766 cites W2066427049 @default.
- W3157258766 cites W2067343156 @default.
- W3157258766 cites W2067946831 @default.
- W3157258766 cites W2069439035 @default.
- W3157258766 cites W2071804748 @default.
- W3157258766 cites W2080574251 @default.
- W3157258766 cites W2082538783 @default.
- W3157258766 cites W2086540526 @default.
- W3157258766 cites W2091778775 @default.
- W3157258766 cites W2096885576 @default.
- W3157258766 cites W2097607539 @default.
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- W3157258766 cites W2115284109 @default.
- W3157258766 cites W2115360097 @default.
- W3157258766 cites W2134071881 @default.
- W3157258766 cites W2225972580 @default.
- W3157258766 cites W2268067576 @default.
- W3157258766 cites W2417290036 @default.
- W3157258766 cites W2518441479 @default.
- W3157258766 cites W2562227897 @default.
- W3157258766 cites W2584380591 @default.
- W3157258766 cites W2620756707 @default.
- W3157258766 cites W2766046358 @default.
- W3157258766 cites W2767674328 @default.
- W3157258766 cites W2770842062 @default.
- W3157258766 cites W2790473576 @default.
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- W3157258766 doi "https://doi.org/10.3390/ijms22094836" @default.
- W3157258766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8125095" @default.
- W3157258766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34063607" @default.
- W3157258766 hasPublicationYear "2021" @default.
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