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- W3157274810 endingPage "4" @default.
- W3157274810 startingPage "4" @default.
- W3157274810 abstract ": The hypothesis that oligometastatic disease (OMD) may be cured through local eradication therapies has precipitated increasing research into the use of locally ablative therapies (LAT) for these patients. Advances in molecular biology have confirmed the presence of clinically and radiographically suspected oligometastatic state at the genomic level. At the same time, technological advances in different treatment modalities (primarily radiation and surgery) have allowed the administration of ablative doses to a broader spectrum of metastatic lesions. Despite increasing efficacy of modern systemic therapies, they are seldom curative. There is growing interest in identifying patients with truly oligometastatic breast cancer (OMBC) and in developing predictive biomarkers to determine which patients are more likely to benefit from LAT. In this review, we discuss data specific to the OMBC setting, the recent advances in understanding oligometastasis biology, the natural history of OMBC including diagnosis and classification, the theoretical basis for LAT, retrospective and prospective data supporting LAT, outcomes associated with LAT and ongoing prospective randomized trials designed to compare LAT and standard of care (SOC) therapies. We especially focus on LAT, primarily surgery and non-invasive stereotactic body radiation therapy (SBRT) for OMBC with references to other tumor types when these other tumor types inform OMBC treatment." @default.
- W3157274810 created "2021-05-10" @default.
- W3157274810 creator A5061500518 @default.
- W3157274810 creator A5065713063 @default.
- W3157274810 date "2022-03-01" @default.
- W3157274810 modified "2023-09-27" @default.
- W3157274810 title "Local therapies for managing oligometastatic breast cancer: a review" @default.
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