Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157278617> ?p ?o ?g. }
- W3157278617 endingPage "104938" @default.
- W3157278617 startingPage "104938" @default.
- W3157278617 abstract "Naringin is a dihydroflavonoid abundantly existed in grapefruit and related citrus species. The double directional adjusting function of estrogenic and anti-estrogenic activities of naringin and its aglycone naringenin has raised concern about possible risks of unwanted interference with endocrine regulation. Herein we assessed the safety of naringin on fertility and early embryonic development toxicity in Sprague-Dawley rats. Twenty-two male and 22 female rats per group were orally given naringin at 0, 50, 250, and 1250 mg/kg/day. Male rats were administered beginning 9 weeks prior to mating and continued until necropsy. Dosing to female began 2 weeks before mating and continued until gestation day 7. There were no obvious effects of naringin on physical signs, animal behavior, and survival rate, although female and male rats from 1250 mg/kg group had lower body weight and tended to have less food consumption. Importantly, no treatment-related effects of naringin were found in relation to fertility and early embryonic development. Under these experimental conditions, it was concluded that the no-observed-adverse-effect levels (NOAEL) of naringin were at least 1250 mg/kg/day for fertility and early embryonic development in rats." @default.
- W3157278617 created "2021-05-10" @default.
- W3157278617 creator A5009452180 @default.
- W3157278617 creator A5011241874 @default.
- W3157278617 creator A5068395856 @default.
- W3157278617 creator A5074386900 @default.
- W3157278617 creator A5084857899 @default.
- W3157278617 creator A5091597765 @default.
- W3157278617 date "2021-07-01" @default.
- W3157278617 modified "2023-10-17" @default.
- W3157278617 title "Fertility and early embryonic development toxicity assessment of naringin in Sprague-Dawley rats" @default.
- W3157278617 cites W1808449960 @default.
- W3157278617 cites W1943473351 @default.
- W3157278617 cites W1981168233 @default.
- W3157278617 cites W1989646713 @default.
- W3157278617 cites W1994827606 @default.
- W3157278617 cites W2003084549 @default.
- W3157278617 cites W2007382713 @default.
- W3157278617 cites W2024404113 @default.
- W3157278617 cites W2033225598 @default.
- W3157278617 cites W2041049648 @default.
- W3157278617 cites W2051088615 @default.
- W3157278617 cites W2079628186 @default.
- W3157278617 cites W2079653198 @default.
- W3157278617 cites W2079752760 @default.
- W3157278617 cites W2080341117 @default.
- W3157278617 cites W2084209221 @default.
- W3157278617 cites W2087617801 @default.
- W3157278617 cites W2106805920 @default.
- W3157278617 cites W2114042463 @default.
- W3157278617 cites W2130250062 @default.
- W3157278617 cites W2134431157 @default.
- W3157278617 cites W2142095611 @default.
- W3157278617 cites W2162612884 @default.
- W3157278617 cites W2162760333 @default.
- W3157278617 cites W2298320027 @default.
- W3157278617 cites W2345005070 @default.
- W3157278617 cites W2514937930 @default.
- W3157278617 cites W2589820228 @default.
- W3157278617 cites W2757204715 @default.
- W3157278617 cites W2771039248 @default.
- W3157278617 cites W2884228635 @default.
- W3157278617 cites W2886888036 @default.
- W3157278617 cites W2888770295 @default.
- W3157278617 cites W2906229116 @default.
- W3157278617 cites W2938788682 @default.
- W3157278617 cites W2944162065 @default.
- W3157278617 cites W2946041279 @default.
- W3157278617 cites W2955200135 @default.
- W3157278617 cites W2988434304 @default.
- W3157278617 cites W2999688805 @default.
- W3157278617 cites W3006866965 @default.
- W3157278617 cites W3009452974 @default.
- W3157278617 cites W3011017038 @default.
- W3157278617 cites W3022567092 @default.
- W3157278617 cites W3089423517 @default.
- W3157278617 cites W3100694443 @default.
- W3157278617 cites W3111346606 @default.
- W3157278617 cites W4236252594 @default.
- W3157278617 doi "https://doi.org/10.1016/j.yrtph.2021.104938" @default.
- W3157278617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33933549" @default.
- W3157278617 hasPublicationYear "2021" @default.
- W3157278617 type Work @default.
- W3157278617 sameAs 3157278617 @default.
- W3157278617 citedByCount "3" @default.
- W3157278617 countsByYear W31572786172022 @default.
- W3157278617 countsByYear W31572786172023 @default.
- W3157278617 crossrefType "journal-article" @default.
- W3157278617 hasAuthorship W3157278617A5009452180 @default.
- W3157278617 hasAuthorship W3157278617A5011241874 @default.
- W3157278617 hasAuthorship W3157278617A5068395856 @default.
- W3157278617 hasAuthorship W3157278617A5074386900 @default.
- W3157278617 hasAuthorship W3157278617A5084857899 @default.
- W3157278617 hasAuthorship W3157278617A5091597765 @default.
- W3157278617 hasConcept C126322002 @default.
- W3157278617 hasConcept C134018914 @default.
- W3157278617 hasConcept C16685009 @default.
- W3157278617 hasConcept C2777335409 @default.
- W3157278617 hasConcept C2779234561 @default.
- W3157278617 hasConcept C2908647359 @default.
- W3157278617 hasConcept C29730261 @default.
- W3157278617 hasConcept C33070731 @default.
- W3157278617 hasConcept C42407357 @default.
- W3157278617 hasConcept C46973012 @default.
- W3157278617 hasConcept C518429986 @default.
- W3157278617 hasConcept C54355233 @default.
- W3157278617 hasConcept C71924100 @default.
- W3157278617 hasConcept C86803240 @default.
- W3157278617 hasConcept C98274493 @default.
- W3157278617 hasConcept C99454951 @default.
- W3157278617 hasConceptScore W3157278617C126322002 @default.
- W3157278617 hasConceptScore W3157278617C134018914 @default.
- W3157278617 hasConceptScore W3157278617C16685009 @default.
- W3157278617 hasConceptScore W3157278617C2777335409 @default.
- W3157278617 hasConceptScore W3157278617C2779234561 @default.
- W3157278617 hasConceptScore W3157278617C2908647359 @default.
- W3157278617 hasConceptScore W3157278617C29730261 @default.
- W3157278617 hasConceptScore W3157278617C33070731 @default.