Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157290428> ?p ?o ?g. }
- W3157290428 abstract "A type III secretion system (T3SS) is used by Gram-negative bacterial pathogens to secrete and translocate a battery of proteins, termed effectors, from the bacteria directly into the host cells. These effectors, which are thought to play a key role in bacterial virulence, hijack and modify the activity of diverse host cell organelles, including mitochondria. Mitochondria-the energy powerhouse of the cell-are important cell organelles that play role in numerous critical cellular processes, including the initiation of apoptosis and the induction of innate immunity. Therefore, it is not surprising that pathogenic bacteria use mitochondrially targeted effectors to control host cell death and immunity pathways. Surprisingly, however, we found that despite their importance, only a limited number of type III secreted effectors have been characterised to target host mitochondria, and the mechanisms underlying their mitochondrial activity have not been sufficiently analysed. These include effectors secreted by the enteric attaching and effacing (A/E), Salmonella and Shigella bacterial pathogens. Here we give an overview of key findings, present gaps in knowledge and hypotheses concerning the mode by which these type III secreted effectors control the host and the bacterial cell life (and death) through targeting mitochondria." @default.
- W3157290428 created "2021-05-10" @default.
- W3157290428 creator A5007892279 @default.
- W3157290428 creator A5009430940 @default.
- W3157290428 creator A5055915600 @default.
- W3157290428 creator A5059274484 @default.
- W3157290428 creator A5071773341 @default.
- W3157290428 creator A5079907424 @default.
- W3157290428 date "2021-06-08" @default.
- W3157290428 modified "2023-10-16" @default.
- W3157290428 title "Type <scp>III</scp> secreted effectors that target mitochondria" @default.
- W3157290428 cites W1544678760 @default.
- W3157290428 cites W1631647907 @default.
- W3157290428 cites W1857478421 @default.
- W3157290428 cites W1966597734 @default.
- W3157290428 cites W1977162717 @default.
- W3157290428 cites W1977620333 @default.
- W3157290428 cites W1980612849 @default.
- W3157290428 cites W1983344225 @default.
- W3157290428 cites W1985645079 @default.
- W3157290428 cites W1993313171 @default.
- W3157290428 cites W1994098589 @default.
- W3157290428 cites W1997087648 @default.
- W3157290428 cites W1997524172 @default.
- W3157290428 cites W2002788678 @default.
- W3157290428 cites W2006652226 @default.
- W3157290428 cites W2012401588 @default.
- W3157290428 cites W2014428435 @default.
- W3157290428 cites W2020986381 @default.
- W3157290428 cites W2027300067 @default.
- W3157290428 cites W2028195725 @default.
- W3157290428 cites W2029862569 @default.
- W3157290428 cites W2035806681 @default.
- W3157290428 cites W2046520563 @default.
- W3157290428 cites W2053984360 @default.
- W3157290428 cites W2065034569 @default.
- W3157290428 cites W2067937183 @default.
- W3157290428 cites W2071681992 @default.
- W3157290428 cites W2082737976 @default.
- W3157290428 cites W2083412868 @default.
- W3157290428 cites W2084435417 @default.
- W3157290428 cites W2088216759 @default.
- W3157290428 cites W2099038753 @default.
- W3157290428 cites W2099203131 @default.
- W3157290428 cites W2100712006 @default.
- W3157290428 cites W2102822478 @default.
- W3157290428 cites W2105515061 @default.
- W3157290428 cites W2110843117 @default.
- W3157290428 cites W2111602293 @default.
- W3157290428 cites W2126923269 @default.
- W3157290428 cites W2130951755 @default.
- W3157290428 cites W2137208505 @default.
- W3157290428 cites W2143398242 @default.
- W3157290428 cites W2152793164 @default.
- W3157290428 cites W2158352115 @default.
- W3157290428 cites W2160682891 @default.
- W3157290428 cites W2161887260 @default.
- W3157290428 cites W2162110497 @default.
- W3157290428 cites W2165660929 @default.
- W3157290428 cites W2313912102 @default.
- W3157290428 cites W2327742653 @default.
- W3157290428 cites W2481707055 @default.
- W3157290428 cites W2583964565 @default.
- W3157290428 cites W2616359747 @default.
- W3157290428 cites W2734937665 @default.
- W3157290428 cites W2750786467 @default.
- W3157290428 cites W2788167885 @default.
- W3157290428 cites W2955096817 @default.
- W3157290428 cites W2963901310 @default.
- W3157290428 cites W2964568280 @default.
- W3157290428 cites W2980622391 @default.
- W3157290428 cites W3006279686 @default.
- W3157290428 cites W3006316914 @default.
- W3157290428 cites W3009711482 @default.
- W3157290428 cites W3010374653 @default.
- W3157290428 cites W3032315201 @default.
- W3157290428 cites W3044130457 @default.
- W3157290428 cites W3085695396 @default.
- W3157290428 doi "https://doi.org/10.1111/cmi.13352" @default.
- W3157290428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33960116" @default.
- W3157290428 hasPublicationYear "2021" @default.
- W3157290428 type Work @default.
- W3157290428 sameAs 3157290428 @default.
- W3157290428 citedByCount "11" @default.
- W3157290428 countsByYear W31572904282021 @default.
- W3157290428 countsByYear W31572904282022 @default.
- W3157290428 countsByYear W31572904282023 @default.
- W3157290428 crossrefType "journal-article" @default.
- W3157290428 hasAuthorship W3157290428A5007892279 @default.
- W3157290428 hasAuthorship W3157290428A5009430940 @default.
- W3157290428 hasAuthorship W3157290428A5055915600 @default.
- W3157290428 hasAuthorship W3157290428A5059274484 @default.
- W3157290428 hasAuthorship W3157290428A5071773341 @default.
- W3157290428 hasAuthorship W3157290428A5079907424 @default.
- W3157290428 hasBestOaLocation W31572904281 @default.
- W3157290428 hasConcept C104317684 @default.
- W3157290428 hasConcept C130211564 @default.
- W3157290428 hasConcept C136449434 @default.
- W3157290428 hasConcept C168240541 @default.
- W3157290428 hasConcept C203014093 @default.