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- W3157291855 endingPage "2201" @default.
- W3157291855 startingPage "2201" @default.
- W3157291855 abstract "Colorectal cancer (CRC) is still one of the most frequent forms of cancer in the world in terms of incidence. Around 40% of CRC patients carry a mutation of the Kirsten rat sarcoma (KRAS) gene, while 10% have a mutation in the B-Raf proto-oncogene serine/threonine kinase (BRAF) gene. These mutations are responsible for dysregulation of the mitogen-associated protein kinase (MAPK) pathway, leading to the proliferation, differentiation, angiogenesis, and resistance to apoptosis of cells. Activation of the MAPK pathway results in adaptive therapeutic resistance, rendering EGFR inhibitors ineffective. This review aims to highlight the recent findings that have improved our understanding of KRAS and BRAF mutations in colorectal cancer and to describe new targeted therapies, used alone or in combination." @default.
- W3157291855 created "2021-05-10" @default.
- W3157291855 creator A5009612396 @default.
- W3157291855 creator A5012760826 @default.
- W3157291855 creator A5043463827 @default.
- W3157291855 date "2021-05-03" @default.
- W3157291855 modified "2023-10-15" @default.
- W3157291855 title "Targeting BRAF and RAS in Colorectal Cancer" @default.
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