FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157296788> ?p ?o ?g. }

• W3157296788 endingPage "5924" @default.
• W3157296788 startingPage "5909" @default.
• W3157296788 abstract "The atypical E3 ligase HOIL-1 forms ester bonds between ubiquitin and serine/threonine residues in proteins, but the physiological roles of this unusual modification are unknown. We now report that IL-18 signalling leading to the production of interferon γ (IFNγ) and granulocyte-macrophage colony-stimulating factor (GM-CSF) is enhanced in cytotoxic T cells from knock-in mice expressing the E3 ligase-inactive HOIL-1[C458S] mutant, demonstrating that the formation of HOIL-1-catalysed ester-linked ubiquitin bonds restricts the activation of this pathway. We show that the interaction of IRAK2 with TRAF6 is required for IL-18-stimulated IFN-γ and GM-CSF production, and that the increased production of these cytokines in cytotoxic T cells from HOIL-1[C458S] mice correlates with an increase in both the number and size of the Lys63/Met1-linked hybrid ubiquitin chains attached to IRAK2 in these cells. In contrast, the secretion of IL-12 and IL-6 and the formation of il-12 and il-6 mRNA induced in bone marrow-derived macrophages (BMDMs) by prolonged stimulation with TLR-activating ligands that signal via myddosomes, which also requires the interaction of IRAK2 with TRAF6, were not increased but modestly reduced in HOIL-1[C458S] BMDM. The decreased production of these cytokines correlated with reduced ubiquitylation of IRAK2. Our results establish that changes in HOIL-1-catalysed ester-linked ubiquitylation can promote or reduce cytokine production depending on the ligand, receptor and immune cell and may be explained by differences in the ubiquitylation of IRAK2." @default.
• W3157296788 created "2021-05-10" @default.
• W3157296788 creator A5010890113 @default.
• W3157296788 creator A5013778882 @default.
• W3157296788 creator A5019453888 @default.
• W3157296788 creator A5021579092 @default.
• W3157296788 creator A5060361210 @default.
• W3157296788 date "2021-05-06" @default.
• W3157296788 modified "2023-09-24" @default.
• W3157296788 title "HOIL‐1‐catalysed, ester‐linked ubiquitylation restricts IL‐18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages" @default.
• W3157296788 cites W1600472471 @default.
• W3157296788 cites W1963751749 @default.
• W3157296788 cites W1993211211 @default.
• W3157296788 cites W2001879129 @default.
• W3157296788 cites W2008646773 @default.
• W3157296788 cites W2009005217 @default.
• W3157296788 cites W2015263036 @default.
• W3157296788 cites W2026512029 @default.
• W3157296788 cites W2031375858 @default.
• W3157296788 cites W2032195857 @default.
• W3157296788 cites W2032731042 @default.
• W3157296788 cites W2032972084 @default.
• W3157296788 cites W2033703058 @default.
• W3157296788 cites W2037454778 @default.
• W3157296788 cites W2038664197 @default.
• W3157296788 cites W2046073277 @default.
• W3157296788 cites W2049486349 @default.
• W3157296788 cites W2063548806 @default.
• W3157296788 cites W2068299688 @default.
• W3157296788 cites W2070251192 @default.
• W3157296788 cites W2070597700 @default.
• W3157296788 cites W2090903823 @default.
• W3157296788 cites W2092797451 @default.
• W3157296788 cites W2115027287 @default.
• W3157296788 cites W2118224132 @default.
• W3157296788 cites W2121772170 @default.
• W3157296788 cites W2122814011 @default.
• W3157296788 cites W2125548716 @default.
• W3157296788 cites W2126185185 @default.
• W3157296788 cites W2131079894 @default.
• W3157296788 cites W2135133228 @default.
• W3157296788 cites W2135332272 @default.
• W3157296788 cites W2137949264 @default.
• W3157296788 cites W2147510335 @default.
• W3157296788 cites W2148468408 @default.
• W3157296788 cites W2148806385 @default.
• W3157296788 cites W2152630268 @default.
• W3157296788 cites W2153819917 @default.
• W3157296788 cites W2156382442 @default.
• W3157296788 cites W2163966171 @default.
• W3157296788 cites W2165591553 @default.
• W3157296788 cites W2170444099 @default.
• W3157296788 cites W2271642981 @default.
• W3157296788 cites W2343275849 @default.
• W3157296788 cites W2525203665 @default.
• W3157296788 cites W2606549900 @default.
• W3157296788 cites W2610465630 @default.
• W3157296788 cites W2615201373 @default.
• W3157296788 cites W2765426211 @default.
• W3157296788 cites W2790995801 @default.
• W3157296788 cites W2801258200 @default.
• W3157296788 cites W2913109339 @default.
• W3157296788 cites W2953128835 @default.
• W3157296788 cites W3010949893 @default.
• W3157296788 doi "https://doi.org/10.1111/febs.15896" @default.
• W3157296788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33932090" @default.
• W3157296788 hasPublicationYear "2021" @default.
• W3157296788 type Work @default.
• W3157296788 sameAs 3157296788 @default.
• W3157296788 citedByCount "11" @default.
• W3157296788 countsByYear W31572967882021 @default.
• W3157296788 countsByYear W31572967882022 @default.
• W3157296788 countsByYear W31572967882023 @default.
• W3157296788 crossrefType "journal-article" @default.
• W3157296788 hasAuthorship W3157296788A5010890113 @default.
• W3157296788 hasAuthorship W3157296788A5013778882 @default.
• W3157296788 hasAuthorship W3157296788A5019453888 @default.
• W3157296788 hasAuthorship W3157296788A5021579092 @default.
• W3157296788 hasAuthorship W3157296788A5060361210 @default.
• W3157296788 hasBestOaLocation W31572967882 @default.
• W3157296788 hasConcept C104317684 @default.
• W3157296788 hasConcept C134459356 @default.
• W3157296788 hasConcept C154317977 @default.
• W3157296788 hasConcept C185592680 @default.
• W3157296788 hasConcept C202751555 @default.
• W3157296788 hasConcept C203014093 @default.
• W3157296788 hasConcept C25602115 @default.
• W3157296788 hasConcept C2778690821 @default.
• W3157296788 hasConcept C502942594 @default.
• W3157296788 hasConcept C55493867 @default.
• W3157296788 hasConcept C62478195 @default.
• W3157296788 hasConcept C86803240 @default.
• W3157296788 hasConcept C95444343 @default.
• W3157296788 hasConceptScore W3157296788C104317684 @default.
• W3157296788 hasConceptScore W3157296788C134459356 @default.
• W3157296788 hasConceptScore W3157296788C154317977 @default.
• W3157296788 hasConceptScore W3157296788C185592680 @default.
• W3157296788 hasConceptScore W3157296788C202751555 @default.

• next