Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157306103> ?p ?o ?g. }
- W3157306103 endingPage "120843" @default.
- W3157306103 startingPage "120843" @default.
- W3157306103 abstract "Water-soluble poly(cyclic imino ether)s (PCIEs) have emerged as promising biocompatible polymers for nanomedicine applications in recent years. Despite their generally accepted stealth properties, there has been no comprehensive evaluation of their interactions with primary immune cells in human blood. Here we present a library of core cross-linked micelles (CCMs) containing various PCIE shells. Well-defined high molar mass CCMs (Mn > 175 kDa, Ð < 1.2) of similar diameter (~20 nm) were synthesised using a cationic ring-opening polymerisation (CROP) – surfactant-free reversible addition-fragmentation chain-transfer (RAFT) emulsion polymerisation strategy. The stealth properties of the different PCIE CCMs were assessed employing a whole human blood assay simulating the complex blood environment. Cell association studies revealed lower associations of poly(2-methyl-2-oxazoline) (PMeOx) and poly(2-ethyl-2-oxazoline) (PEtOx) CCMs with blood immune cells compared to the respective poly(2-oxazine) (POz) CCMs. Noteworthy, PMeOx CCMs outperformed all other reported CCMs, showing overall low associations and only negligible differences in the presence and absence of serum proteins. This study highlights the importance of investigating individual nanomaterials under physiologically relevant conditions and further strengthens the position of PMeOx as a highly promising stealth material for biomedical applications." @default.
- W3157306103 created "2021-05-10" @default.
- W3157306103 creator A5003954971 @default.
- W3157306103 creator A5009042033 @default.
- W3157306103 creator A5014665196 @default.
- W3157306103 creator A5024264553 @default.
- W3157306103 creator A5054025307 @default.
- W3157306103 creator A5069605168 @default.
- W3157306103 creator A5081266050 @default.
- W3157306103 date "2021-07-01" @default.
- W3157306103 modified "2023-10-16" @default.
- W3157306103 title "Interactions of core cross-linked poly(2-oxazoline) and poly(2-oxazine) micelles with immune cells in human blood" @default.
- W3157306103 cites W1965097716 @default.
- W3157306103 cites W1976915466 @default.
- W3157306103 cites W1987259801 @default.
- W3157306103 cites W1990447486 @default.
- W3157306103 cites W1990796256 @default.
- W3157306103 cites W1992215904 @default.
- W3157306103 cites W1997308573 @default.
- W3157306103 cites W1997555157 @default.
- W3157306103 cites W1997886061 @default.
- W3157306103 cites W2001539590 @default.
- W3157306103 cites W2005674807 @default.
- W3157306103 cites W2006000676 @default.
- W3157306103 cites W2016445978 @default.
- W3157306103 cites W2021278432 @default.
- W3157306103 cites W2023308046 @default.
- W3157306103 cites W2032852708 @default.
- W3157306103 cites W2039844496 @default.
- W3157306103 cites W2057722853 @default.
- W3157306103 cites W2057910069 @default.
- W3157306103 cites W2064816464 @default.
- W3157306103 cites W2065735911 @default.
- W3157306103 cites W2066746162 @default.
- W3157306103 cites W2067923079 @default.
- W3157306103 cites W2069454375 @default.
- W3157306103 cites W2079556026 @default.
- W3157306103 cites W2084978441 @default.
- W3157306103 cites W2091832363 @default.
- W3157306103 cites W2096196478 @default.
- W3157306103 cites W2110710720 @default.
- W3157306103 cites W2120119011 @default.
- W3157306103 cites W2125353766 @default.
- W3157306103 cites W2128713327 @default.
- W3157306103 cites W2134715422 @default.
- W3157306103 cites W2136170495 @default.
- W3157306103 cites W2141888014 @default.
- W3157306103 cites W2151477149 @default.
- W3157306103 cites W2164841185 @default.
- W3157306103 cites W2166723286 @default.
- W3157306103 cites W2167534105 @default.
- W3157306103 cites W2167947764 @default.
- W3157306103 cites W2170562632 @default.
- W3157306103 cites W2284550715 @default.
- W3157306103 cites W2395687931 @default.
- W3157306103 cites W2520312360 @default.
- W3157306103 cites W2528021581 @default.
- W3157306103 cites W2573157670 @default.
- W3157306103 cites W2588642729 @default.
- W3157306103 cites W2597905827 @default.
- W3157306103 cites W2614118668 @default.
- W3157306103 cites W2617507069 @default.
- W3157306103 cites W2741222691 @default.
- W3157306103 cites W2752331171 @default.
- W3157306103 cites W2766204992 @default.
- W3157306103 cites W2777154769 @default.
- W3157306103 cites W2796267463 @default.
- W3157306103 cites W2801159784 @default.
- W3157306103 cites W2807377921 @default.
- W3157306103 cites W2884408118 @default.
- W3157306103 cites W2887501271 @default.
- W3157306103 cites W2889676738 @default.
- W3157306103 cites W2911325239 @default.
- W3157306103 cites W2912528798 @default.
- W3157306103 cites W2918146375 @default.
- W3157306103 cites W2934543521 @default.
- W3157306103 cites W2940036175 @default.
- W3157306103 cites W2965467664 @default.
- W3157306103 cites W2966407494 @default.
- W3157306103 cites W2974215257 @default.
- W3157306103 cites W2995977166 @default.
- W3157306103 cites W2997475719 @default.
- W3157306103 cites W3000169996 @default.
- W3157306103 cites W3008389939 @default.
- W3157306103 cites W3027356782 @default.
- W3157306103 cites W3043626412 @default.
- W3157306103 cites W3083291968 @default.
- W3157306103 cites W3117253466 @default.
- W3157306103 doi "https://doi.org/10.1016/j.biomaterials.2021.120843" @default.
- W3157306103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33984635" @default.
- W3157306103 hasPublicationYear "2021" @default.
- W3157306103 type Work @default.
- W3157306103 sameAs 3157306103 @default.
- W3157306103 citedByCount "24" @default.
- W3157306103 countsByYear W31573061032021 @default.
- W3157306103 countsByYear W31573061032022 @default.
- W3157306103 countsByYear W31573061032023 @default.
- W3157306103 crossrefType "journal-article" @default.