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• W3157326797 abstract "Multiple Myeloma (MM) develops almost exclusively within the Bone Marrow (BM), highlighting the critical role of the microenvironment in conditioning disease progression and resistance to drugs. Indeed, while the therapeutic armamentarium for MM has significantly improved over the past 20 years, the disease remains ultimately incurable. This failure may depend on the high phenotypic and genetic heterogeneity of MM, but also on the paucity and inadequacy of two-dimensional (2D) conventional preclinical models in reproducing MM within the BM. In the present paper, we provide a brief updated overview on MM BM microenvironment. We then discuss newly developed preclinical models mimicking MM/microenvironment interactions, including three-dimensional (3D), gel-based, in vitro models and a novel ex vivo system of isolated tumor and stromal cells cultured in bioreactor. Potential applications of each model, relative to investigation of MM pathogenic mechanisms and prediction of the best drug/combination for each individual patient will be also evaluated." @default.
• W3157326797 created "2021-05-10" @default.
• W3157326797 creator A5020048731 @default.
• W3157326797 creator A5026667594 @default.
• W3157326797 creator A5060214201 @default.
• W3157326797 creator A5076929140 @default.
• W3157326797 date "2021-07-28" @default.
• W3157326797 modified "2023-10-18" @default.
• W3157326797 title "3D Models of Surrogate Multiple Myeloma Bone Marrow Microenvironments: Insights on Disease Pathophysiology and Patient-Specific Response to Drugs" @default.
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• W3157326797 doi "https://doi.org/10.5772/intechopen.95333" @default.
• W3157326797 hasPublicationYear "2021" @default.

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