Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157344548> ?p ?o ?g. }
- W3157344548 endingPage "335" @default.
- W3157344548 startingPage "316" @default.
- W3157344548 abstract "Recent advances in genome editing, especially CRISPR-Cas nucleases, have revolutionized both laboratory research and clinical therapeutics. CRISPR-Cas nucleases, together with the DNA damage repair pathway in cells, enable both genetic diversification by classical non-homologous end joining (c-NHEJ) and precise genome modification by homology-based repair (HBR). Genome editing in zygotes is a convenient way to edit the germline, paving the way for animal disease model generation, as well as human embryo genome editing therapy for some life-threatening and incurable diseases. HBR efficiency is highly dependent on the DNA donor that is utilized as a repair template. Here, we review recent progress in improving CRISPR-Cas nuclease-induced HBR in mammalian embryos by designing a suitable DNA donor. Moreover, we want to provide a guide for producing animal disease models and correcting genetic mutations through CRISPR-Cas nuclease-induced HBR in mammalian embryos. Finally, we discuss recent developments in precise genome-modification technology based on the CRISPR-Cas system." @default.
- W3157344548 created "2021-05-10" @default.
- W3157344548 creator A5010278187 @default.
- W3157344548 creator A5022536823 @default.
- W3157344548 creator A5038002338 @default.
- W3157344548 creator A5061192275 @default.
- W3157344548 creator A5085403624 @default.
- W3157344548 date "2021-05-04" @default.
- W3157344548 modified "2023-10-07" @default.
- W3157344548 title "Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing" @default.
- W3157344548 cites W1091016337 @default.
- W3157344548 cites W1798017247 @default.
- W3157344548 cites W1841331176 @default.
- W3157344548 cites W1845461494 @default.
- W3157344548 cites W1963513334 @default.
- W3157344548 cites W1971157495 @default.
- W3157344548 cites W1977709885 @default.
- W3157344548 cites W1982969769 @default.
- W3157344548 cites W1987739153 @default.
- W3157344548 cites W1999068651 @default.
- W3157344548 cites W2001161498 @default.
- W3157344548 cites W2002764930 @default.
- W3157344548 cites W2003171404 @default.
- W3157344548 cites W2018456465 @default.
- W3157344548 cites W2019144299 @default.
- W3157344548 cites W2019749991 @default.
- W3157344548 cites W2025696956 @default.
- W3157344548 cites W2029343098 @default.
- W3157344548 cites W2032764699 @default.
- W3157344548 cites W2045435533 @default.
- W3157344548 cites W2058792860 @default.
- W3157344548 cites W2064815984 @default.
- W3157344548 cites W2065395033 @default.
- W3157344548 cites W2068668324 @default.
- W3157344548 cites W2072299899 @default.
- W3157344548 cites W2072309186 @default.
- W3157344548 cites W2092637814 @default.
- W3157344548 cites W2110058183 @default.
- W3157344548 cites W2112444085 @default.
- W3157344548 cites W2135034945 @default.
- W3157344548 cites W2140754284 @default.
- W3157344548 cites W2141825721 @default.
- W3157344548 cites W2168460045 @default.
- W3157344548 cites W2229738114 @default.
- W3157344548 cites W2230199130 @default.
- W3157344548 cites W2237671266 @default.
- W3157344548 cites W2253584908 @default.
- W3157344548 cites W2260024370 @default.
- W3157344548 cites W2260480416 @default.
- W3157344548 cites W2278979929 @default.
- W3157344548 cites W2283705032 @default.
- W3157344548 cites W2285096912 @default.
- W3157344548 cites W2336828812 @default.
- W3157344548 cites W2343876552 @default.
- W3157344548 cites W2399406935 @default.
- W3157344548 cites W2410840366 @default.
- W3157344548 cites W2510638623 @default.
- W3157344548 cites W2530601336 @default.
- W3157344548 cites W2547418311 @default.
- W3157344548 cites W2550079706 @default.
- W3157344548 cites W2558957819 @default.
- W3157344548 cites W2571507769 @default.
- W3157344548 cites W2572003722 @default.
- W3157344548 cites W2577713652 @default.
- W3157344548 cites W2588556918 @default.
- W3157344548 cites W2590493137 @default.
- W3157344548 cites W2593664217 @default.
- W3157344548 cites W2594121715 @default.
- W3157344548 cites W2594473698 @default.
- W3157344548 cites W2601123609 @default.
- W3157344548 cites W2604891032 @default.
- W3157344548 cites W2607273379 @default.
- W3157344548 cites W2610556191 @default.
- W3157344548 cites W2614850398 @default.
- W3157344548 cites W2614952490 @default.
- W3157344548 cites W2616802735 @default.
- W3157344548 cites W2622049469 @default.
- W3157344548 cites W2656673982 @default.
- W3157344548 cites W2726053863 @default.
- W3157344548 cites W2738542367 @default.
- W3157344548 cites W2740810575 @default.
- W3157344548 cites W2746994345 @default.
- W3157344548 cites W2748819410 @default.
- W3157344548 cites W2761326476 @default.
- W3157344548 cites W2766599608 @default.
- W3157344548 cites W2767634557 @default.
- W3157344548 cites W2768098631 @default.
- W3157344548 cites W2769263426 @default.
- W3157344548 cites W2783507030 @default.
- W3157344548 cites W2794894092 @default.
- W3157344548 cites W2796841946 @default.
- W3157344548 cites W2801589383 @default.
- W3157344548 cites W2804432738 @default.
- W3157344548 cites W2804655893 @default.
- W3157344548 cites W2805452967 @default.
- W3157344548 cites W2805837749 @default.
- W3157344548 cites W2807624799 @default.
- W3157344548 cites W2809309743 @default.