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• W3157345518 abstract "Radioembolization (RE) has been established as an effective treatment for both primary and secondary liver cancers. However, work continues in the area of dose optimization, specifically in understanding dose to both tumor and normal tissue, which have been shown to be important determinants of oncologic outcomes and complications, respectively. Data comparing the two commercially available RE products in terms of dose distribution is lacking. The purpose of this study was to determine the difference in dose distribution of RE patients undergoing treatment with resin as compared to glass microspheres. Between January 1, 2012, and December 31, 2018, a total of 176 patients underwent 203 RE treatments were included. The patients’ electronic medical records were reviewed for treatment details and laboratory values. Dose distribution was determined utilizing simplicit90y software (Mirada, San Francisco, CA). Tumor to normal (T:N) ratio was calculated by dividing the counts in the tumor by the counts in the normal tissue with a SPECT CT. 67 (67/176, 38.1%) patients underwent 76 (76/203, 37.4%) with resin microspheres (Varian medical systems, Palo Alto, CA) while 109 (109/176, 62.9%) patients underwent 127 (127/203, 63.6%) treatments with glass microspheres (Boston Scientific, Marlborough, MA). The pretreat MAA T:N ratio did not differ significantly between those patients treated with resin and those treated with glass (2.2 ± 3.48 vs. 2.86 ± 2.79, P = 0.14). The average post RE T:N ratio of those treated with resin microspheres was significantly less than those treated with glass microspheres (1.7 ± 0.96 vs. 2.8 ± 1.61, P = 0.00001). When looking at resin patients who had RE to < 450 mL of liver the T:N was lower in this group (1.38 ± 0.75) as compared to those where the perfused area was > 450 mL (1.76 ± 0.99), but this did not reach significance (P = 0.09). The same was not true of glass, which showed minimal difference when compared using the same methodology (T:N < 450 mL 2.68 ± 1.18 vs. > 450 mL 2.91 ± 1.84, P = 0.23). When comparing the post RE T:N ratio of resin patients who received RE < 450 mL of liver to similar glass patients the T:N was significantly higher in glass patients (1.38 ± 0.75 vs. 2.68 ± 1.18, P = 0.0002). Similarly, the T:N was lower in resin patients undergoing RE of > 450 mL of liver (1.76 ± 0.99 vs. 2.91 ± 1.84, P = 0.00001). The distribution to tumor and normal tissue of resin and glass microspheres differs significantly, and resin microspheres distribution may be affected by the size amount of perfused volume to which they are delivered." @default.
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• W3157345518 date "2021-05-01" @default.
• W3157345518 modified "2023-09-25" @default.
• W3157345518 title "Abstract No. 445 Dose distribution in radioembolization: a comparison between glass and resin microspheres" @default.
• W3157345518 doi "https://doi.org/10.1016/j.jvir.2021.03.254" @default.
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