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- W3157346399 abstract "Abstract Clathrin-mediated endocytosis in plants is an essential process but the underlying mechanisms are poorly understood, not least because of the extreme intracellular turgor pressure acting against the formation of endocytic vesicles. In contrast to other models, plant endocytosis is independent of actin, indicating a mechanistically distinct solution. Here, by using biochemical and advanced microscopy approaches, we show that the plant-specific TPLATE complex acts outside of endocytic vesicles as a mediator of membrane bending. Cells with disrupted TPLATE fail to generate spherical vesicles, and in vitro biophysical assays identified protein domains with membrane bending capability. These results redefine the role of the TPLATE complex as a key component of the evolutionarily distinct mechanism mediating membrane bending against high turgor pressure to drive endocytosis in plant cells. One Sentence Summary While plant CME is actin independent, we identify that the evolutionarily ancient octameric TPLATE complex mediates membrane bending against high turgor pressure in plant clathrin-mediated endocytosis." @default.
- W3157346399 created "2021-05-10" @default.
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- W3157346399 date "2021-04-27" @default.
- W3157346399 modified "2023-10-15" @default.
- W3157346399 title "The TPLATE complex mediates membrane bending during plant clathrin-mediated endocytosis" @default.
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- W3157346399 doi "https://doi.org/10.1101/2021.04.26.441441" @default.
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