FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157353277> ?p ?o ?g. }

• W3157353277 abstract "This study was conducted to investigate the effects of early supplementation during 4 to 18 d of age with Lactobacillus plantarum (LP) in liquid diets on intestinal innate immune response in young piglets infected with enterotoxigenic Escherichia coli (ETEC) K88. Seventy-two barrow piglets at 4 d old were assigned to basal or LP-supplemented liquid diet (5 × 1010 CFU·kg-1). On day 15, piglets from each group were orally challenged with either ETEC K88 (1 × 108 CFU·kg-1) or the same amount of phosphate-buffered saline. The intestinal mucosa, mesenteric lymph node (MLN), and spleen samples were collected on day 18. Here, we found that LP pretreatment significantly decreased the mRNA relative expression of inflammatory cytokines (interleukin [IL]-1β, IL-8, and tumor necrosis factor-α), porcine β-defensin 2 (pBD-2), and mucins (MUC1 and MUC4) in the jejunal mucosa in piglets challenged with ETEC K88 (P < 0.05). Moreover, LP significantly decreased the ileal mucosa mRNA relative expression of IL-8 and MUC4 in young piglets challenged with ETEC K88 (P < 0.05). Furthermore, the piglets of the LP + ETEC K88 group had lower protein levels of IL-8, secretory immunoglobulin A, pBD-2, and MUC4 in the jejunal mucosa than those challenged with ETEC K88 (P < 0.05). Besides, LP supplementation reduced the percentage of gamma/delta T cells receptor (γδTCR) and CD172a+ (SWC3+) cells in MLN and the percentage of γδTCR cells in the spleen of young piglets after the ETEC K88 challenge. Supplementation with LP in liquid diets prevented the upregulated protein abundance of toll-like receptor (TLR) 4, phosphorylation-p38, and phosphorylation-extracellular signal-regulated protein kinases in the jejunal mucosa induced by ETEC K88 (P < 0.05). In conclusion, LP supplementation in liquid diet possesses anti-inflammatory activity and modulates the intestinal innate immunity during the early life of young piglets challenged with ETEC K88, which might be attributed to the suppression of TLR4-mediated mitogen-activated protein kinase signaling pathways. Early supplementation with LP in liquid diets regulates the innate immune response, representing a promising immunoregulation strategy for maintaining intestinal health in weaned piglets." @default.
• W3157353277 created "2021-05-10" @default.
• W3157353277 creator A5003997243 @default.
• W3157353277 creator A5024805996 @default.
• W3157353277 creator A5026964863 @default.
• W3157353277 creator A5043597276 @default.
• W3157353277 creator A5050221403 @default.
• W3157353277 creator A5053525271 @default.
• W3157353277 creator A5071484736 @default.
• W3157353277 date "2021-04-29" @default.
• W3157353277 modified "2023-10-09" @default.
• W3157353277 title "Early supplementation with <i>Lactobacillus plantarum</i> in liquid diet modulates intestinal innate immunity through toll-like receptor 4-mediated mitogen-activated protein kinase signaling pathways in young piglets challenged with <i>Escherichia coli</i> K88" @default.
• W3157353277 cites W1486167830 @default.
• W3157353277 cites W1584297034 @default.
• W3157353277 cites W1604582052 @default.
• W3157353277 cites W1912578996 @default.
• W3157353277 cites W1970936381 @default.
• W3157353277 cites W1971087663 @default.
• W3157353277 cites W1992244925 @default.
• W3157353277 cites W2000233667 @default.
• W3157353277 cites W2003705537 @default.
• W3157353277 cites W2015074127 @default.
• W3157353277 cites W2020362730 @default.
• W3157353277 cites W2025198517 @default.
• W3157353277 cites W2027606763 @default.
• W3157353277 cites W2039232870 @default.
• W3157353277 cites W2041482657 @default.
• W3157353277 cites W2043326218 @default.
• W3157353277 cites W2047077529 @default.
• W3157353277 cites W2047851930 @default.
• W3157353277 cites W2055440159 @default.
• W3157353277 cites W2066914296 @default.
• W3157353277 cites W2068593094 @default.
• W3157353277 cites W2087322994 @default.
• W3157353277 cites W2089008914 @default.
• W3157353277 cites W2092581426 @default.
• W3157353277 cites W2098177737 @default.
• W3157353277 cites W2101181380 @default.
• W3157353277 cites W2103015500 @default.
• W3157353277 cites W2106694537 @default.
• W3157353277 cites W2107277218 @default.
• W3157353277 cites W2110101542 @default.
• W3157353277 cites W2110851176 @default.
• W3157353277 cites W2119419023 @default.
• W3157353277 cites W2125127505 @default.
• W3157353277 cites W2132130871 @default.
• W3157353277 cites W2143516276 @default.
• W3157353277 cites W2145365066 @default.
• W3157353277 cites W2151437990 @default.
• W3157353277 cites W2152242641 @default.
• W3157353277 cites W2166252717 @default.
• W3157353277 cites W2166415057 @default.
• W3157353277 cites W2168128529 @default.
• W3157353277 cites W2177828635 @default.
• W3157353277 cites W2192080449 @default.
• W3157353277 cites W2267072039 @default.
• W3157353277 cites W2273794078 @default.
• W3157353277 cites W2283643794 @default.
• W3157353277 cites W2296191975 @default.
• W3157353277 cites W2314750107 @default.
• W3157353277 cites W2418275298 @default.
• W3157353277 cites W2608431723 @default.
• W3157353277 cites W2755292622 @default.
• W3157353277 cites W2766683044 @default.
• W3157353277 cites W2768915715 @default.
• W3157353277 cites W2807517165 @default.
• W3157353277 cites W2811201620 @default.
• W3157353277 cites W2888303999 @default.
• W3157353277 cites W2913948152 @default.
• W3157353277 cites W2914302080 @default.
• W3157353277 cites W2940927217 @default.
• W3157353277 cites W2942391834 @default.
• W3157353277 cites W2947034894 @default.
• W3157353277 cites W2969847257 @default.
• W3157353277 cites W2972719859 @default.
• W3157353277 cites W2974639402 @default.
• W3157353277 cites W2980674775 @default.
• W3157353277 cites W2985497807 @default.
• W3157353277 cites W2990292615 @default.
• W3157353277 cites W3004513505 @default.
• W3157353277 cites W3082373704 @default.
• W3157353277 cites W3091625059 @default.
• W3157353277 doi "https://doi.org/10.1093/jas/skab128" @default.
• W3157353277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8212570" @default.
• W3157353277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33928383" @default.
• W3157353277 hasPublicationYear "2021" @default.
• W3157353277 type Work @default.
• W3157353277 sameAs 3157353277 @default.
• W3157353277 citedByCount "7" @default.
• W3157353277 countsByYear W31573532772022 @default.
• W3157353277 countsByYear W31573532772023 @default.
• W3157353277 crossrefType "journal-article" @default.
• W3157353277 hasAuthorship W3157353277A5003997243 @default.
• W3157353277 hasAuthorship W3157353277A5024805996 @default.
• W3157353277 hasAuthorship W3157353277A5026964863 @default.
• W3157353277 hasAuthorship W3157353277A5043597276 @default.
• W3157353277 hasAuthorship W3157353277A5050221403 @default.
• W3157353277 hasAuthorship W3157353277A5053525271 @default.
• W3157353277 hasAuthorship W3157353277A5071484736 @default.
• W3157353277 hasBestOaLocation W31573532772 @default.

• next