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- W3157357644 abstract "Abstract Studies have shown that melatonin (MLT) can delay ovarian aging, but the mechanism has not been fully elucidated. Here we show that granulosa cells isolated from mice follicles can synthesize MLT; the addition of MLT in ovary culture system inhibited follicle activation and growth; In vivo experiments indicated that injections of MLT to mice during the follicle activation phase can reduce the number of activated follicles by inhibiting the PI3K-AKT-FOXO3 pathway; during the early follicle growth phase, MLT administration suppressed follicle growth and atresia, and multiple pathways involved in folliculogenesis, including PI3K-AKT, were suppressed; MLT deficiency in mice increased follicle activation and atresia, and eventually accelerated age-related fertility decline; finally, we demonstrated that prolonged high-dose MLT intake had no obvious adverse effect. This study presents more insight into the roles of MLT in reproductive regulation that endogenous MLT delays ovarian aging by inhibiting follicle activation, growth and atresia." @default.
- W3157357644 created "2021-05-10" @default.
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- W3157357644 date "2021-05-06" @default.
- W3157357644 modified "2023-09-23" @default.
- W3157357644 title "Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve" @default.
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- W3157357644 doi "https://doi.org/10.1038/s42003-021-02042-z" @default.
- W3157357644 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8102596" @default.
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- W3157357644 hasPublicationYear "2021" @default.
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