FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157357895> ?p ?o ?g. }

• W3157357895 endingPage "2122" @default.
• W3157357895 startingPage "2109" @default.
• W3157357895 abstract "Many physiological and pathological pathways are dependent on gene-specific on/off regulation of transcription. Some genes are repressed, while others are activated. Although many previous studies have analyzed the mechanisms of gene-specific repression and activation, these studies are mainly based on the use of candidate genes, which are either repressed or activated, without simultaneously comparing and contrasting both groups of genes. There is also insufficient consideration of gene locations. Here we describe an integrated machine learning approach, using LASSO-regularized logistic regression, to model gene-specific repression and activation and the underlying contribution of chromatin interactions. LASSO-regularized logistic regression accurately predicted gene-specific transcriptional events and robustly detected the rate-limiting factors that underlie the differences of gene activation and repression. An example was provided by the leukemogenic transcription factor AML1-ETO, which is responsible for 10-15 percent of all acute myeloid leukemia cases. The analysis of AML1-ETO has also revealed novel networks of chromatin interactions and uncovered an unexpected role for E-proteins in AML1-ETO-p300 interactions and a role for the pre-existing gene state in governing the transcriptional response. Our results show that logistic regression-based probabilistic modeling is a promising tool to decipher mechanisms that integrate gene regulation and chromatin interactions in regulated transcription." @default.
• W3157357895 created "2021-05-10" @default.
• W3157357895 creator A5014838961 @default.
• W3157357895 creator A5024659860 @default.
• W3157357895 creator A5033115045 @default.
• W3157357895 creator A5061350013 @default.
• W3157357895 date "2021-11-01" @default.
• W3157357895 modified "2023-10-18" @default.
• W3157357895 title "Computational Modeling of Gene-Specific Transcriptional Repression, Activation and Chromatin Interactions in Leukemogenesis by LASSO-Regularized Logistic Regression" @default.
• W3157357895 cites W1524671781 @default.
• W3157357895 cites W1794161984 @default.
• W3157357895 cites W1978308802 @default.
• W3157357895 cites W1992391979 @default.
• W3157357895 cites W2006299620 @default.
• W3157357895 cites W2007882538 @default.
• W3157357895 cites W2014677321 @default.
• W3157357895 cites W2016921876 @default.
• W3157357895 cites W2017196344 @default.
• W3157357895 cites W2020677165 @default.
• W3157357895 cites W2029798558 @default.
• W3157357895 cites W2042949070 @default.
• W3157357895 cites W2049094182 @default.
• W3157357895 cites W2057228135 @default.
• W3157357895 cites W2059506882 @default.
• W3157357895 cites W2076149854 @default.
• W3157357895 cites W2092912586 @default.
• W3157357895 cites W2119862467 @default.
• W3157357895 cites W2125668148 @default.
• W3157357895 cites W2127996002 @default.
• W3157357895 cites W2145283451 @default.
• W3157357895 cites W2165649312 @default.
• W3157357895 cites W2172400873 @default.
• W3157357895 cites W2314367247 @default.
• W3157357895 cites W2323326409 @default.
• W3157357895 cites W2424483111 @default.
• W3157357895 cites W2492513888 @default.
• W3157357895 cites W2581124489 @default.
• W3157357895 cites W2611010089 @default.
• W3157357895 cites W2615562152 @default.
• W3157357895 cites W2777698002 @default.
• W3157357895 cites W2781855674 @default.
• W3157357895 cites W2911108160 @default.
• W3157357895 cites W2912276189 @default.
• W3157357895 cites W2918443266 @default.
• W3157357895 cites W2922815614 @default.
• W3157357895 cites W2941032314 @default.
• W3157357895 cites W2943244154 @default.
• W3157357895 cites W2945038365 @default.
• W3157357895 cites W2951508767 @default.
• W3157357895 cites W2969701269 @default.
• W3157357895 cites W2999342380 @default.
• W3157357895 cites W3002247544 @default.
• W3157357895 cites W3008301126 @default.
• W3157357895 doi "https://doi.org/10.1109/tcbb.2021.3078128" @default.
• W3157357895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8572318" @default.
• W3157357895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33961561" @default.
• W3157357895 hasPublicationYear "2021" @default.
• W3157357895 type Work @default.
• W3157357895 sameAs 3157357895 @default.
• W3157357895 citedByCount "4" @default.
• W3157357895 countsByYear W31573578952022 @default.
• W3157357895 countsByYear W31573578952023 @default.
• W3157357895 crossrefType "journal-article" @default.
• W3157357895 hasAuthorship W3157357895A5014838961 @default.
• W3157357895 hasAuthorship W3157357895A5024659860 @default.
• W3157357895 hasAuthorship W3157357895A5033115045 @default.
• W3157357895 hasAuthorship W3157357895A5061350013 @default.
• W3157357895 hasBestOaLocation W31573578952 @default.
• W3157357895 hasConcept C104317684 @default.
• W3157357895 hasConcept C119857082 @default.
• W3157357895 hasConcept C150194340 @default.
• W3157357895 hasConcept C151956035 @default.
• W3157357895 hasConcept C165864922 @default.
• W3157357895 hasConcept C186310378 @default.
• W3157357895 hasConcept C41008148 @default.
• W3157357895 hasConcept C54355233 @default.
• W3157357895 hasConcept C60644358 @default.
• W3157357895 hasConcept C67339327 @default.
• W3157357895 hasConcept C70721500 @default.
• W3157357895 hasConcept C83640560 @default.
• W3157357895 hasConcept C86339819 @default.
• W3157357895 hasConcept C86803240 @default.
• W3157357895 hasConceptScore W3157357895C104317684 @default.
• W3157357895 hasConceptScore W3157357895C119857082 @default.
• W3157357895 hasConceptScore W3157357895C150194340 @default.
• W3157357895 hasConceptScore W3157357895C151956035 @default.
• W3157357895 hasConceptScore W3157357895C165864922 @default.
• W3157357895 hasConceptScore W3157357895C186310378 @default.
• W3157357895 hasConceptScore W3157357895C41008148 @default.
• W3157357895 hasConceptScore W3157357895C54355233 @default.
• W3157357895 hasConceptScore W3157357895C60644358 @default.
• W3157357895 hasConceptScore W3157357895C67339327 @default.
• W3157357895 hasConceptScore W3157357895C70721500 @default.
• W3157357895 hasConceptScore W3157357895C83640560 @default.
• W3157357895 hasConceptScore W3157357895C86339819 @default.
• W3157357895 hasConceptScore W3157357895C86803240 @default.
• W3157357895 hasFunder F4320310094 @default.
• W3157357895 hasFunder F4320312021 @default.

• next