Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157365510> ?p ?o ?g. }
- W3157365510 endingPage "408" @default.
- W3157365510 startingPage "397" @default.
- W3157365510 abstract "Abstract In this work, enantiomeric separation of a drug combination of two chiral drugs, namely, atenolol and chlorthalidone, is described. Prior investigation of the effect of different variables on the resolution of the enantiomers' peaks and the total run time represented by the retention time of the last eluted peak was conducted using face‐centered composite design. Twenty‐two experiments were carried out by varying the chiral stationary phase type as a categorical factor and mobile phase composition including the percentage of ethanol and percentage of diethylamine as continuous factors. According to the optimization process, a mobile phase consisting of hexane:ethanol:DEA:TFA (60:40:0.2:0.1%, v/v/v/v) pumped at flow rate 1 ml min −1 onto Lux‐Cellulose 2 stationary phase was applied for the chiral separation and quantification of the drug combination at 230 nm. Application of the developed method to the pharmaceutical formulation of this combination was successfully performed, and satisfactory percentage of recoveries was obtained. The method was also fully validated following International Conference on Harmonization (ICH) guidelines. This method could be of high value and relevance for application in quality control laboratories." @default.
- W3157365510 created "2021-05-10" @default.
- W3157365510 creator A5035359853 @default.
- W3157365510 creator A5035750388 @default.
- W3157365510 creator A5049369246 @default.
- W3157365510 creator A5073882188 @default.
- W3157365510 creator A5074073824 @default.
- W3157365510 date "2021-05-08" @default.
- W3157365510 modified "2023-10-12" @default.
- W3157365510 title "Experimental design optimization of simultaneous enantiomeric separation of atenolol and chlorthalidone binary mixture by high‐performance liquid chromatography using polysaccharide‐based stationary phases" @default.
- W3157365510 cites W1584512000 @default.
- W3157365510 cites W1992928295 @default.
- W3157365510 cites W1996746536 @default.
- W3157365510 cites W2001899961 @default.
- W3157365510 cites W2002854600 @default.
- W3157365510 cites W2003622343 @default.
- W3157365510 cites W2004886997 @default.
- W3157365510 cites W2007738313 @default.
- W3157365510 cites W2009889966 @default.
- W3157365510 cites W2018543118 @default.
- W3157365510 cites W2029868691 @default.
- W3157365510 cites W2038404607 @default.
- W3157365510 cites W2039125061 @default.
- W3157365510 cites W2039169022 @default.
- W3157365510 cites W2043934526 @default.
- W3157365510 cites W2048656045 @default.
- W3157365510 cites W2057405018 @default.
- W3157365510 cites W2061531056 @default.
- W3157365510 cites W2068304780 @default.
- W3157365510 cites W2070327459 @default.
- W3157365510 cites W2071863555 @default.
- W3157365510 cites W2075189641 @default.
- W3157365510 cites W2168922201 @default.
- W3157365510 cites W2339710659 @default.
- W3157365510 cites W2578784145 @default.
- W3157365510 cites W2602942566 @default.
- W3157365510 cites W2743573184 @default.
- W3157365510 cites W2752049626 @default.
- W3157365510 cites W2762561802 @default.
- W3157365510 cites W2763731060 @default.
- W3157365510 cites W2769468650 @default.
- W3157365510 cites W2790137453 @default.
- W3157365510 cites W2796357494 @default.
- W3157365510 cites W2897820155 @default.
- W3157365510 cites W2915772638 @default.
- W3157365510 cites W2945167264 @default.
- W3157365510 cites W2966456135 @default.
- W3157365510 cites W2988698325 @default.
- W3157365510 doi "https://doi.org/10.1002/chir.23315" @default.
- W3157365510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33964031" @default.
- W3157365510 hasPublicationYear "2021" @default.
- W3157365510 type Work @default.
- W3157365510 sameAs 3157365510 @default.
- W3157365510 citedByCount "6" @default.
- W3157365510 countsByYear W31573655102021 @default.
- W3157365510 countsByYear W31573655102022 @default.
- W3157365510 countsByYear W31573655102023 @default.
- W3157365510 crossrefType "journal-article" @default.
- W3157365510 hasAuthorship W3157365510A5035359853 @default.
- W3157365510 hasAuthorship W3157365510A5035750388 @default.
- W3157365510 hasAuthorship W3157365510A5049369246 @default.
- W3157365510 hasAuthorship W3157365510A5073882188 @default.
- W3157365510 hasAuthorship W3157365510A5074073824 @default.
- W3157365510 hasConcept C113196181 @default.
- W3157365510 hasConcept C126838900 @default.
- W3157365510 hasConcept C138268822 @default.
- W3157365510 hasConcept C150077022 @default.
- W3157365510 hasConcept C150394285 @default.
- W3157365510 hasConcept C154945302 @default.
- W3157365510 hasConcept C178790620 @default.
- W3157365510 hasConcept C185592680 @default.
- W3157365510 hasConcept C199360897 @default.
- W3157365510 hasConcept C2776525901 @default.
- W3157365510 hasConcept C2777449572 @default.
- W3157365510 hasConcept C2778088075 @default.
- W3157365510 hasConcept C41008148 @default.
- W3157365510 hasConcept C43617362 @default.
- W3157365510 hasConcept C486523 @default.
- W3157365510 hasConcept C64452783 @default.
- W3157365510 hasConcept C71924100 @default.
- W3157365510 hasConcept C73826308 @default.
- W3157365510 hasConcept C84393581 @default.
- W3157365510 hasConcept C92397422 @default.
- W3157365510 hasConceptScore W3157365510C113196181 @default.
- W3157365510 hasConceptScore W3157365510C126838900 @default.
- W3157365510 hasConceptScore W3157365510C138268822 @default.
- W3157365510 hasConceptScore W3157365510C150077022 @default.
- W3157365510 hasConceptScore W3157365510C150394285 @default.
- W3157365510 hasConceptScore W3157365510C154945302 @default.
- W3157365510 hasConceptScore W3157365510C178790620 @default.
- W3157365510 hasConceptScore W3157365510C185592680 @default.
- W3157365510 hasConceptScore W3157365510C199360897 @default.
- W3157365510 hasConceptScore W3157365510C2776525901 @default.
- W3157365510 hasConceptScore W3157365510C2777449572 @default.
- W3157365510 hasConceptScore W3157365510C2778088075 @default.
- W3157365510 hasConceptScore W3157365510C41008148 @default.
- W3157365510 hasConceptScore W3157365510C43617362 @default.
- W3157365510 hasConceptScore W3157365510C486523 @default.