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• W3157375737 abstract "Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug resistance and severe side effects. Amplification of intracellular oxidative stress is considered as an effective strategy to induce cancer cell death. The purpose of this study was to develop a novel strategy that can amplify the intracellular oxidative stress for synergistic cascade cancer therapy.A novel nanocomposite, composed of folic acid (FA) modified mesoporous silica-coated gold nanostar (GNS@MSNs-FA) and traditional Chinese medicine lycorine (Ly), was rationally designed and developed. Under near-infrared (NIR) irradiation, the obtained GNS@MSNs-FA/Ly could promote a high level of ROS production via inducing mitochondrial dysfunction and potent endoplasmic reticulum (ER) stress. Moreover, glutathione (GSH) depletion during ER stress could reduce ROS scavenging and further enable efficient amplification of intracellular oxidative stress. Both in vitro and in vivo studies demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation exhibited excellent antitumor efficacy without noticeable toxicity in MNNG/HOS tumor-bearing mice.All these results demonstrated that GNS@MSNs-FA/Ly coupled with NIR irradiation could dramatically amplify the intra-tumoral oxidative stress, exhibiting excellent antitumor ability without obvious systemic toxicity. Taken together, this promising strategy provides a new avenue for the effective cancer synergetic therapy and future clinical translation." @default.
• W3157375737 created "2021-05-10" @default.
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• W3157375737 date "2021-07-27" @default.
• W3157375737 modified "2023-09-28" @default.
• W3157375737 title "Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy" @default.
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• W3157375737 doi "https://doi.org/10.1186/s12951-021-00933-1" @default.
• W3157375737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8314456" @default.
• W3157375737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34315494" @default.
• W3157375737 hasPublicationYear "2021" @default.
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