FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157385145> ?p ?o ?g. }

• W3157385145 endingPage "629" @default.
• W3157385145 startingPage "616" @default.
• W3157385145 abstract "Insulin has complex effects on cell growth, metabolism and differentiation, and these effects are mediated by a cell-surface bound receptor and eventually a cascade of intracellular signaling events. Among the several metabolic and growth-promoting effects of insulin, insulin resistance is defined as an attenuated effect of insulin on glucose metabolism, primarily the limited export of blood glucose into skeletal muscle and adipose tissue. On the other hand, not all the signaling pathways and insulin-responsive tissues are equally affected, and some effects other than the metabolic actions of insulin are overexpressed. Ovaries and the adrenal glands are two examples of tissues remaining sensitive to insulin actions where insulin may contribute to increased androgen secretion. Polycystic ovary syndrome (PCOS) is the most common form of androgen excess disorder (AED), and its pathogenesis is closely associated with insulin resistance. Patients with idiopathic hirsutism also exhibit insulin resistance, albeit lower than patients with PCOS. Although it is not as evident as in PCOS, patients with congenital adrenal hyperplasia may have insulin resistance, which may be further exacerbated with glucocorticoid overtreatment and obesity. Among patients with severe insulin resistance syndromes, irrespective of the type of disease, hyperinsulinemia promotes ovarian androgen synthesis independently of gonadotropins. It is highly debated in whom and how insulin resistance should be diagnosed and treated among patients with AEDs, including PCOS. It is not suitable to administer an insulin sensitizer relying on only some mathematical models used for estimating insulin resistance. Instead, the treatment decision should be based on the constellation of the signs, symptoms and presence of obesity; acanthosis nigricans; and some laboratory abnormalities such as impaired glucose tolerance and impaired fasting glucose." @default.
• W3157385145 created "2021-05-10" @default.
• W3157385145 creator A5017215792 @default.
• W3157385145 creator A5043774214 @default.
• W3157385145 creator A5070299374 @default.
• W3157385145 date "2021-05-15" @default.
• W3157385145 modified "2023-10-18" @default.
• W3157385145 title "Role of insulin and insulin resistance in androgen excess disorders" @default.
• W3157385145 cites W1573613964 @default.
• W3157385145 cites W1933397016 @default.
• W3157385145 cites W1966336914 @default.
• W3157385145 cites W1967263394 @default.
• W3157385145 cites W1977875804 @default.
• W3157385145 cites W1983824804 @default.
• W3157385145 cites W1984323756 @default.
• W3157385145 cites W1984470571 @default.
• W3157385145 cites W1985010098 @default.
• W3157385145 cites W1989901309 @default.
• W3157385145 cites W1991856256 @default.
• W3157385145 cites W1996287714 @default.
• W3157385145 cites W1998493448 @default.
• W3157385145 cites W1999093110 @default.
• W3157385145 cites W2008869160 @default.
• W3157385145 cites W2012916349 @default.
• W3157385145 cites W2012944104 @default.
• W3157385145 cites W2014618027 @default.
• W3157385145 cites W2021371211 @default.
• W3157385145 cites W2030685863 @default.
• W3157385145 cites W2033009146 @default.
• W3157385145 cites W2037023961 @default.
• W3157385145 cites W2040724729 @default.
• W3157385145 cites W2074076323 @default.
• W3157385145 cites W2076485751 @default.
• W3157385145 cites W2077720498 @default.
• W3157385145 cites W2079229176 @default.
• W3157385145 cites W2084516758 @default.
• W3157385145 cites W2092866516 @default.
• W3157385145 cites W2095269627 @default.
• W3157385145 cites W2097310478 @default.
• W3157385145 cites W2101771026 @default.
• W3157385145 cites W2104303958 @default.
• W3157385145 cites W2106027229 @default.
• W3157385145 cites W2124838987 @default.
• W3157385145 cites W2126393987 @default.
• W3157385145 cites W2134583596 @default.
• W3157385145 cites W2136179119 @default.
• W3157385145 cites W2136864398 @default.
• W3157385145 cites W2137367546 @default.
• W3157385145 cites W2143411942 @default.
• W3157385145 cites W2147264139 @default.
• W3157385145 cites W2147293407 @default.
• W3157385145 cites W2149809800 @default.
• W3157385145 cites W2156669838 @default.
• W3157385145 cites W2157970550 @default.
• W3157385145 cites W2162941823 @default.
• W3157385145 cites W2164418602 @default.
• W3157385145 cites W2171843668 @default.
• W3157385145 cites W2292109795 @default.
• W3157385145 cites W2305775835 @default.
• W3157385145 cites W2340100375 @default.
• W3157385145 cites W2470379208 @default.
• W3157385145 cites W2508860317 @default.
• W3157385145 cites W2580786621 @default.
• W3157385145 cites W2624836659 @default.
• W3157385145 cites W2728981453 @default.
• W3157385145 cites W2763635492 @default.
• W3157385145 cites W2763794285 @default.
• W3157385145 cites W2783637456 @default.
• W3157385145 cites W2885509473 @default.
• W3157385145 cites W2914351460 @default.
• W3157385145 cites W2972351765 @default.
• W3157385145 cites W3008418226 @default.
• W3157385145 cites W3010450878 @default.
• W3157385145 cites W3018643315 @default.
• W3157385145 cites W3021369174 @default.
• W3157385145 cites W3033436049 @default.
• W3157385145 cites W4210400066 @default.
• W3157385145 cites W4248534187 @default.
• W3157385145 cites W4251646064 @default.
• W3157385145 doi "https://doi.org/10.4239/wjd.v12.i5.616" @default.
• W3157385145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8107978" @default.
• W3157385145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33995849" @default.
• W3157385145 hasPublicationYear "2021" @default.
• W3157385145 type Work @default.
• W3157385145 sameAs 3157385145 @default.
• W3157385145 citedByCount "31" @default.
• W3157385145 countsByYear W31573851452021 @default.
• W3157385145 countsByYear W31573851452022 @default.
• W3157385145 countsByYear W31573851452023 @default.
• W3157385145 crossrefType "journal-article" @default.
• W3157385145 hasAuthorship W3157385145A5017215792 @default.
• W3157385145 hasAuthorship W3157385145A5043774214 @default.
• W3157385145 hasAuthorship W3157385145A5070299374 @default.
• W3157385145 hasBestOaLocation W31573851451 @default.
• W3157385145 hasConcept C126322002 @default.
• W3157385145 hasConcept C134018914 @default.
• W3157385145 hasConcept C2777391703 @default.
• W3157385145 hasConcept C2777911890 @default.

• next