Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157390589> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3157390589 endingPage "87" @default.
- W3157390589 startingPage "72" @default.
- W3157390589 abstract "Abstract Overloading stress–induced condylar cartilage degeneration acts as the main pathologic change in temporomandibular joint osteoarthritis (TMJ‐OA). However, the progression of degeneration and the ability for self‐repair remain poorly understood. Here, we explored the progression of cartilage degeneration by dividing pathological stages using a steady mouth‐opening mouse model. Then, we observed changes of cartilage by removing the loading at different stages to test the potential self‐repair after degeneration induced. Three‐dimensional confocal microscopy combined with histology and micro‐CT scanning was applied to examine TMJ at different stages of degeneration before and after self‐repair. We found the cartilage underwent progressive and thorough degeneration as the overloading stress developed. During the initial adaptation stage, robust proliferation of posteromedial cartilage began at the area of direct loading. Subsequently, widespread chondrocyte apoptosis was found, followed by new chondrocyte proliferation in aggregates with matrix degradation and subchondral bone catabolism. Finally, with cartilage surface damage, the degeneration reached a point where the lesion could not be reversed by self‐repair. While the cartilage nearly returned to normal when the interference was removed within 5 days. These results suggested overloading force induces a pathological process of successive degeneration in TMJ cartilage, which can be reversed by self‐repair at early stages." @default.
- W3157390589 created "2021-05-10" @default.
- W3157390589 creator A5000374269 @default.
- W3157390589 creator A5022589591 @default.
- W3157390589 creator A5046763452 @default.
- W3157390589 creator A5059069124 @default.
- W3157390589 creator A5059758586 @default.
- W3157390589 date "2021-05-07" @default.
- W3157390589 modified "2023-10-16" @default.
- W3157390589 title "Overloading stress–induced progressive degeneration and self‐repair in condylar cartilage" @default.
- W3157390589 cites W1461340049 @default.
- W3157390589 cites W1696082547 @default.
- W3157390589 cites W1954235586 @default.
- W3157390589 cites W1981788636 @default.
- W3157390589 cites W1993134707 @default.
- W3157390589 cites W1999622719 @default.
- W3157390589 cites W2009872571 @default.
- W3157390589 cites W2011973051 @default.
- W3157390589 cites W2022906864 @default.
- W3157390589 cites W2042125277 @default.
- W3157390589 cites W2043101769 @default.
- W3157390589 cites W2072527296 @default.
- W3157390589 cites W2077073151 @default.
- W3157390589 cites W2080344305 @default.
- W3157390589 cites W2081048095 @default.
- W3157390589 cites W2126708643 @default.
- W3157390589 cites W2140529481 @default.
- W3157390589 cites W2154940310 @default.
- W3157390589 cites W2213204018 @default.
- W3157390589 cites W2490483434 @default.
- W3157390589 cites W2490525963 @default.
- W3157390589 cites W2569153440 @default.
- W3157390589 cites W2593430728 @default.
- W3157390589 cites W2610577174 @default.
- W3157390589 cites W2907989475 @default.
- W3157390589 cites W2937578637 @default.
- W3157390589 cites W2944075970 @default.
- W3157390589 cites W2965167489 @default.
- W3157390589 cites W2984565522 @default.
- W3157390589 cites W3025590102 @default.
- W3157390589 cites W3033161377 @default.
- W3157390589 cites W3043448198 @default.
- W3157390589 cites W4232024554 @default.
- W3157390589 cites W4245265600 @default.
- W3157390589 doi "https://doi.org/10.1111/nyas.14606" @default.
- W3157390589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33962484" @default.
- W3157390589 hasPublicationYear "2021" @default.
- W3157390589 type Work @default.
- W3157390589 sameAs 3157390589 @default.
- W3157390589 citedByCount "15" @default.
- W3157390589 countsByYear W31573905892022 @default.
- W3157390589 countsByYear W31573905892023 @default.
- W3157390589 crossrefType "journal-article" @default.
- W3157390589 hasAuthorship W3157390589A5000374269 @default.
- W3157390589 hasAuthorship W3157390589A5022589591 @default.
- W3157390589 hasAuthorship W3157390589A5046763452 @default.
- W3157390589 hasAuthorship W3157390589A5059069124 @default.
- W3157390589 hasAuthorship W3157390589A5059758586 @default.
- W3157390589 hasConcept C105702510 @default.
- W3157390589 hasConcept C142724271 @default.
- W3157390589 hasConcept C204787440 @default.
- W3157390589 hasConcept C2776164576 @default.
- W3157390589 hasConcept C2779354088 @default.
- W3157390589 hasConcept C2780202543 @default.
- W3157390589 hasConcept C2780550940 @default.
- W3157390589 hasConcept C2781403057 @default.
- W3157390589 hasConcept C71924100 @default.
- W3157390589 hasConcept C96646087 @default.
- W3157390589 hasConceptScore W3157390589C105702510 @default.
- W3157390589 hasConceptScore W3157390589C142724271 @default.
- W3157390589 hasConceptScore W3157390589C204787440 @default.
- W3157390589 hasConceptScore W3157390589C2776164576 @default.
- W3157390589 hasConceptScore W3157390589C2779354088 @default.
- W3157390589 hasConceptScore W3157390589C2780202543 @default.
- W3157390589 hasConceptScore W3157390589C2780550940 @default.
- W3157390589 hasConceptScore W3157390589C2781403057 @default.
- W3157390589 hasConceptScore W3157390589C71924100 @default.
- W3157390589 hasConceptScore W3157390589C96646087 @default.
- W3157390589 hasIssue "1" @default.
- W3157390589 hasLocation W31573905891 @default.
- W3157390589 hasLocation W31573905892 @default.
- W3157390589 hasOpenAccess W3157390589 @default.
- W3157390589 hasPrimaryLocation W31573905891 @default.
- W3157390589 hasRelatedWork W2033329636 @default.
- W3157390589 hasRelatedWork W2149203964 @default.
- W3157390589 hasRelatedWork W2149326605 @default.
- W3157390589 hasRelatedWork W2347987689 @default.
- W3157390589 hasRelatedWork W2380877877 @default.
- W3157390589 hasRelatedWork W2795645377 @default.
- W3157390589 hasRelatedWork W2907052381 @default.
- W3157390589 hasRelatedWork W2923472591 @default.
- W3157390589 hasRelatedWork W4294605774 @default.
- W3157390589 hasRelatedWork W60272466 @default.
- W3157390589 hasVolume "1503" @default.
- W3157390589 isParatext "false" @default.
- W3157390589 isRetracted "false" @default.
- W3157390589 magId "3157390589" @default.
- W3157390589 workType "article" @default.