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• W3157418764 abstract "We seek to establish whether high-density lipoprotein HDL metabolism and reverse cholesterol transport (RCT) impairment is an intrinsic feature of familial hypercholesterolemia (FH). RCT from macrophages (m-RCT), a vascular cell type of major influence on atherosclerosis, is impaired in FH due to defective low-density lipoprotein receptor (LDLR) function via both the HDL- and LDL-mediated pathways. Potential mechanisms include impaired HDL metabolism, which is linked to increased LDL levels, as well as the increased transport of cellular unesterified cholesterol to LDL, which presents a defective catabolism. RCT dysfunction is consistently associated with mutation-positive FH linked to decreased HDL levels as well as impaired HDL remodeling and LDLR function. It remains to be explored whether these alterations are also present in less well-characterized forms of FH, such as cases with no identified mutations, and whether they are fully corrected by current standard treatments." @default.
• W3157418764 created "2021-05-10" @default.
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• W3157418764 date "2021-04-29" @default.
• W3157418764 modified "2023-10-16" @default.
• W3157418764 title "Reverse Cholesterol Transport Dysfunction Is a Feature of Familial Hypercholesterolemia" @default.
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• W3157418764 doi "https://doi.org/10.1007/s11883-021-00928-1" @default.
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