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- W3157461035 abstract "Abstract Recent technical advances have led to the discovery of novel functions of extrachromosomal DNA (ecDNA) in multiple cancer types. Studies have revealed that cancer-associated ecDNA shows a unique circular shape and contains oncogenes that are more frequently amplified than that in linear chromatin DNA. Importantly, the ecDNA-mediated amplification of oncogenes was frequently found in most cancers but rare in normal tissues. Multiple reports have shown that ecDNA has a profound impact on oncogene activation, genomic instability, drug sensitivity, tumor heterogeneity and tumor immunology, therefore may offer the potential for cancer diagnosis and therapeutics. Nevertheless, the underlying mechanisms and future applications of ecDNA remain to be determined. In this review, we summarize the basic concepts, biological functions and molecular mechanisms of ecDNA. We also provide novel insights into the fundamental role of ecDNA in cancer." @default.
- W3157461035 created "2021-05-10" @default.
- W3157461035 creator A5039242210 @default.
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- W3157461035 date "2021-04-26" @default.
- W3157461035 modified "2023-09-25" @default.
- W3157461035 title "Small ring has big potential: insights into extrachromosomal DNA in cancer" @default.
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- W3157461035 doi "https://doi.org/10.1186/s12935-021-01936-6" @default.
- W3157461035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8077740" @default.
- W3157461035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33902601" @default.
- W3157461035 hasPublicationYear "2021" @default.
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