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- W3157461191 endingPage "103348" @default.
- W3157461191 startingPage "103348" @default.
- W3157461191 abstract "The asymptomatic behaviour of esophageal cancerous cells at early stages develops advanced clinical presentation of the disease, resulting in poor prognosis and curbed intervention of therapeutic modalities. The endeavours to detect diagnostic and prognostic markers have been proven futile at the clinical platform. While several biomarkers have been investigated, including CYFRA 21–1, carcinoembryonic antigen and squamous cell carcinoma antigen, their sensitivity has not proved consistently satisfactory across the various stages of esophageal cancer. Hence, there is an impending requirement of biomarkers for early diagnosis and better prognosis. In the recent past, next generation sequencing (NGS) tool has emerged as an important tool to highlight the hallmarks of esophageal cancer (EC). This review summarizes the changes/mutations occurred in tumor cells during carcinogenesis and addresses the contribution of NGS techniques, viz. whole genome sequencing (WGS), RNA-Sequencing and Exome sequencing (ES), in EC. Additionally, this review highlights the connection between the findings from these techniques. An effort has been made to emphasize the genes affected and involved signaling pathway in EC. Further, investigations of these mutated genes would not only shed light on the relevant genes to be studied but also help in the better management and cure through personalized therapy." @default.
- W3157461191 created "2021-05-10" @default.
- W3157461191 creator A5008965885 @default.
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- W3157461191 creator A5048954522 @default.
- W3157461191 creator A5056879199 @default.
- W3157461191 creator A5078458015 @default.
- W3157461191 date "2021-06-01" @default.
- W3157461191 modified "2023-10-16" @default.
- W3157461191 title "Cross-talk between next generation sequencing methodologies to identify genomic signatures of esophageal cancer" @default.
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