Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157465363> ?p ?o ?g. }
- W3157465363 abstract "The limitations of current cancer treatments have stimulated the application of nanotechnology to develop more effective and safer cancer therapies. Remarkable progress has been made in the development of nanomedicine to overcome issues associated with conventional cancer treatment, including low drug solubility, insufficient targeting, and drug resistance. The modulation of nanoparticles allows the improvement of drug pharmacokinetics, leading to improved targeting and reduced side effects. In addition, nanoparticles can be conjugated to ligands that specifically target cancer cells. Furthermore, strategies that exploit tumor characteristics to locally trigger drug release have shown to increase targeted drug delivery. However, although some clinical successes have been achieved, most nanomedicines fail to reach the clinic. Factors that hinder clinical translation vary from the complexity of design, incomplete understanding of biological mechanisms, and high demands during the manufacturing process. Clinical translation might be improved by combining knowledge from different disciplines such as cell biology, chemistry, and tumor pathophysiology. An increased understanding on how nanoparticle modifications affect biological systems is pivotal to improve design, eventually aiding development of more effective nanomedicines. This review summarizes the key successes that have been made in nanomedicine, including improved drug delivery and release by polymeric nanoparticles as well as the introduction of strategies that overcome drug resistance. In addition, the application of nanomedicine in immunotherapy is discussed, and several remaining challenges addressed." @default.
- W3157465363 created "2021-05-10" @default.
- W3157465363 creator A5053964169 @default.
- W3157465363 creator A5054940822 @default.
- W3157465363 creator A5072433789 @default.
- W3157465363 date "2021-04-30" @default.
- W3157465363 modified "2023-09-23" @default.
- W3157465363 title "Nanomedicine in cancer therapy: promises and hurdles of polymeric nanoparticles" @default.
- W3157465363 cites W1492360552 @default.
- W3157465363 cites W1547361471 @default.
- W3157465363 cites W1596848781 @default.
- W3157465363 cites W1769308960 @default.
- W3157465363 cites W1844274376 @default.
- W3157465363 cites W1897724420 @default.
- W3157465363 cites W1936415051 @default.
- W3157465363 cites W1965540482 @default.
- W3157465363 cites W1976301747 @default.
- W3157465363 cites W1983692618 @default.
- W3157465363 cites W1989230986 @default.
- W3157465363 cites W1990796256 @default.
- W3157465363 cites W2001291822 @default.
- W3157465363 cites W2004969426 @default.
- W3157465363 cites W2007445917 @default.
- W3157465363 cites W2016318198 @default.
- W3157465363 cites W2021651355 @default.
- W3157465363 cites W2026798351 @default.
- W3157465363 cites W2032088674 @default.
- W3157465363 cites W2043069157 @default.
- W3157465363 cites W2048497409 @default.
- W3157465363 cites W2048912984 @default.
- W3157465363 cites W2067923079 @default.
- W3157465363 cites W2072210671 @default.
- W3157465363 cites W2072624182 @default.
- W3157465363 cites W2076218507 @default.
- W3157465363 cites W2083710155 @default.
- W3157465363 cites W2087414776 @default.
- W3157465363 cites W2089773350 @default.
- W3157465363 cites W2092049057 @default.
- W3157465363 cites W2092527323 @default.
- W3157465363 cites W2096593771 @default.
- W3157465363 cites W2102866212 @default.
- W3157465363 cites W2103707992 @default.
- W3157465363 cites W2105241081 @default.
- W3157465363 cites W2107806098 @default.
- W3157465363 cites W2112237903 @default.
- W3157465363 cites W2115824449 @default.
- W3157465363 cites W2119325996 @default.
- W3157465363 cites W2125792957 @default.
- W3157465363 cites W2133756116 @default.
- W3157465363 cites W2134726513 @default.
- W3157465363 cites W2143463421 @default.
- W3157465363 cites W2148845753 @default.
- W3157465363 cites W2154323346 @default.
- W3157465363 cites W2160684474 @default.
- W3157465363 cites W2161190483 @default.
- W3157465363 cites W2164520862 @default.
- W3157465363 cites W2169302611 @default.
- W3157465363 cites W2182835963 @default.
- W3157465363 cites W2237742134 @default.
- W3157465363 cites W2286406480 @default.
- W3157465363 cites W2295763130 @default.
- W3157465363 cites W2302028835 @default.
- W3157465363 cites W2312223853 @default.
- W3157465363 cites W2315117765 @default.
- W3157465363 cites W2318642195 @default.
- W3157465363 cites W2335559092 @default.
- W3157465363 cites W2401094910 @default.
- W3157465363 cites W2405973915 @default.
- W3157465363 cites W2413359062 @default.
- W3157465363 cites W2414781026 @default.
- W3157465363 cites W2425706463 @default.
- W3157465363 cites W2509554736 @default.
- W3157465363 cites W2531244467 @default.
- W3157465363 cites W2549628327 @default.
- W3157465363 cites W2553273735 @default.
- W3157465363 cites W2554773181 @default.
- W3157465363 cites W2563907218 @default.
- W3157465363 cites W2565349538 @default.
- W3157465363 cites W2565382901 @default.
- W3157465363 cites W2584378351 @default.
- W3157465363 cites W2585721815 @default.
- W3157465363 cites W2589721301 @default.
- W3157465363 cites W2591101768 @default.
- W3157465363 cites W2596914017 @default.
- W3157465363 cites W2604347510 @default.
- W3157465363 cites W2604485484 @default.
- W3157465363 cites W2605757478 @default.
- W3157465363 cites W2611827085 @default.
- W3157465363 cites W2614363750 @default.
- W3157465363 cites W2614719195 @default.
- W3157465363 cites W2750715468 @default.
- W3157465363 cites W2766725583 @default.
- W3157465363 cites W2767074976 @default.
- W3157465363 cites W2768155247 @default.
- W3157465363 cites W2771155547 @default.
- W3157465363 cites W2771518877 @default.
- W3157465363 cites W2774901009 @default.
- W3157465363 cites W2776171184 @default.
- W3157465363 cites W2780190620 @default.
- W3157465363 cites W2788819736 @default.