FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157473016> ?p ?o ?g. }

• W3157473016 endingPage "2919" @default.
• W3157473016 startingPage "2909" @default.
• W3157473016 abstract "The renin-angiotensin-aldosterone system plays a key role in blood pressure (BP) regulation and is the target of several antihypertensive medications. Renal denervation (RDN) is thought to interrupt the sympathetic-mediated neurohormonal pathway as part of its mechanism of action to reduce BP. The purpose of this study was to evaluate plasma renin activity (PRA) and aldosterone before and after RDN and to assess whether these baseline neuroendocrine markers predict response to RDN. Analyses were conducted in patients with confirmed absence of antihypertensive medication. Aldosterone and PRA levels were compared at baseline and 3 months post-procedure for RDN and sham control groups. Patients in the SPYRAL HTN-OFF MED Pivotal trial were separated into 2 groups, those with baseline PRA ≥0.65 ng/ml/h (n = 110) versus <0.65 ng/ml/h (n = 116). Follow-up treatment differences between RDN and sham control groups were adjusted for baseline values using multivariable linear regression models. Baseline PRA was similar between RDN and control groups (1.0 ± 1.1 ng/ml/h vs. 1.1 ± 1.1 ng/ml/h; p = 0.37). Change in PRA at 3 months from baseline was significantly greater for RDN compared with control subjects (−0.2 ± 1.0 ng/ml/h; p = 0.019 vs. 0.1 ± 0.9 ng/ml/h; p = 0.14), p = 0.001 for RDN versus control subjects, and similar differences were seen for aldosterone: RDN compared with control subjects (−1.2 ± 6.4 ng/dl; p = 0.04 vs. 0.4 ± 5.4 ng/dl; p = 0.40), p = 0.011. Treatment differences at 3 months in 24-h and office systolic blood pressure (SBP) for RDN versus control patients were significantly greater for patients with baseline PRA ≥0.65 ng/ml/h versus <0.65 ng/ml/h, despite similar baseline BP. Differences in office SBP changes according to baseline PRA were also observed earlier at 2 weeks post-RDN. Plasma renin activity and aldosterone levels for RDN patients were significantly reduced at 3 months when compared with baseline as well as when compared with sham control. Higher baseline PRA levels were associated with a significantly greater reduction in office and 24-h SBP. (SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study; NCT02439749)" @default.
• W3157473016 created "2021-05-10" @default.
• W3157473016 creator A5005151561 @default.
• W3157473016 creator A5007202415 @default.
• W3157473016 creator A5008678419 @default.
• W3157473016 creator A5017415495 @default.
• W3157473016 creator A5017863780 @default.
• W3157473016 creator A5021041564 @default.
• W3157473016 creator A5023301357 @default.
• W3157473016 creator A5023436129 @default.
• W3157473016 creator A5029674394 @default.
• W3157473016 creator A5040218653 @default.
• W3157473016 creator A5041032923 @default.
• W3157473016 creator A5042851664 @default.
• W3157473016 creator A5045230091 @default.
• W3157473016 creator A5047317486 @default.
• W3157473016 creator A5049235067 @default.
• W3157473016 creator A5061241784 @default.
• W3157473016 creator A5063816519 @default.
• W3157473016 creator A5065425489 @default.
• W3157473016 creator A5073685454 @default.
• W3157473016 creator A5088857006 @default.
• W3157473016 date "2021-06-01" @default.
• W3157473016 modified "2023-10-16" @default.
• W3157473016 title "Changes in Plasma Renin Activity After Renal Artery Sympathetic Denervation" @default.
• W3157473016 cites W1175366871 @default.
• W3157473016 cites W1583834060 @default.
• W3157473016 cites W1795322358 @default.
• W3157473016 cites W1963919923 @default.
• W3157473016 cites W1979956481 @default.
• W3157473016 cites W1982387835 @default.
• W3157473016 cites W1984932444 @default.
• W3157473016 cites W1994487234 @default.
• W3157473016 cites W2025945113 @default.
• W3157473016 cites W2032359266 @default.
• W3157473016 cites W2073336434 @default.
• W3157473016 cites W2094770146 @default.
• W3157473016 cites W2106472209 @default.
• W3157473016 cites W2115136352 @default.
• W3157473016 cites W2162145993 @default.
• W3157473016 cites W2330582839 @default.
• W3157473016 cites W2415410175 @default.
• W3157473016 cites W2417689488 @default.
• W3157473016 cites W2504974245 @default.
• W3157473016 cites W2505293722 @default.
• W3157473016 cites W2539716134 @default.
• W3157473016 cites W2748414916 @default.
• W3157473016 cites W2782242012 @default.
• W3157473016 cites W2794516536 @default.
• W3157473016 cites W2802848571 @default.
• W3157473016 cites W2803910972 @default.
• W3157473016 cites W2804838656 @default.
• W3157473016 cites W2953292043 @default.
• W3157473016 cites W3004837451 @default.
• W3157473016 cites W3013841246 @default.
• W3157473016 cites W3013889389 @default.
• W3157473016 cites W3015612915 @default.
• W3157473016 cites W3034082335 @default.
• W3157473016 cites W919201310 @default.
• W3157473016 doi "https://doi.org/10.1016/j.jacc.2021.04.044" @default.
• W3157473016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33957242" @default.
• W3157473016 hasPublicationYear "2021" @default.
• W3157473016 type Work @default.
• W3157473016 sameAs 3157473016 @default.
• W3157473016 citedByCount "51" @default.
• W3157473016 countsByYear W31574730162021 @default.
• W3157473016 countsByYear W31574730162022 @default.
• W3157473016 countsByYear W31574730162023 @default.
• W3157473016 crossrefType "journal-article" @default.
• W3157473016 hasAuthorship W3157473016A5005151561 @default.
• W3157473016 hasAuthorship W3157473016A5007202415 @default.
• W3157473016 hasAuthorship W3157473016A5008678419 @default.
• W3157473016 hasAuthorship W3157473016A5017415495 @default.
• W3157473016 hasAuthorship W3157473016A5017863780 @default.
• W3157473016 hasAuthorship W3157473016A5021041564 @default.
• W3157473016 hasAuthorship W3157473016A5023301357 @default.
• W3157473016 hasAuthorship W3157473016A5023436129 @default.
• W3157473016 hasAuthorship W3157473016A5029674394 @default.
• W3157473016 hasAuthorship W3157473016A5040218653 @default.
• W3157473016 hasAuthorship W3157473016A5041032923 @default.
• W3157473016 hasAuthorship W3157473016A5042851664 @default.
• W3157473016 hasAuthorship W3157473016A5045230091 @default.
• W3157473016 hasAuthorship W3157473016A5047317486 @default.
• W3157473016 hasAuthorship W3157473016A5049235067 @default.
• W3157473016 hasAuthorship W3157473016A5061241784 @default.
• W3157473016 hasAuthorship W3157473016A5063816519 @default.
• W3157473016 hasAuthorship W3157473016A5065425489 @default.
• W3157473016 hasAuthorship W3157473016A5073685454 @default.
• W3157473016 hasAuthorship W3157473016A5088857006 @default.
• W3157473016 hasBestOaLocation W31574730161 @default.
• W3157473016 hasConcept C126322002 @default.
• W3157473016 hasConcept C126894567 @default.
• W3157473016 hasConcept C134018914 @default.
• W3157473016 hasConcept C138976137 @default.
• W3157473016 hasConcept C164705383 @default.
• W3157473016 hasConcept C198710026 @default.
• W3157473016 hasConcept C2776634560 @default.
• W3157473016 hasConcept C2776805190 @default.

• next