FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3157478118> ?p ?o ?g. }

• W3157478118 abstract "PAX2 is a transcription factor essential for kidney development and the main causative gene for renal coloboma syndrome (RCS). The mechanisms of PAX2 action during kidney development have been evaluated in mice but not in humans. This is a critical gap in knowledge since important differences have been reported in kidney development in the two species. In the present study, we hypothesized that key human PAX2-dependent kidney development genes are differentially expressed in nephron progenitor cells from induced pluripotent stem cells (iPSCs) in patients with RCS relative to healthy individuals. Cap analysis of gene expression revealed 189 candidate promoters and 71 candidate enhancers that were differentially activated by PAX2 in this system in three patients with RCS with PAX2 mutations. By comparing this list with the list of candidate Pax2-regulated mouse kidney development genes obtained from the Functional Annotation of the Mouse/Mammalian (FANTOM) database, we prioritized 17 genes. Furthermore, we ranked three genes-PBX1, POSTN, and ITGA9-as the top candidates based on closely aligned expression kinetics with PAX2 in the iPSC culture system and susceptibility to suppression by a Pax2 inhibitor in cultured mouse embryonic kidney explants. Identification of these genes may provide important information to clarify the pathogenesis of RCS, human kidney development, and kidney regeneration." @default.
• W3157478118 created "2021-05-10" @default.
• W3157478118 creator A5005250682 @default.
• W3157478118 creator A5007831725 @default.
• W3157478118 creator A5010644445 @default.
• W3157478118 creator A5012216609 @default.
• W3157478118 creator A5015204894 @default.
• W3157478118 creator A5021082730 @default.
• W3157478118 creator A5022995997 @default.
• W3157478118 creator A5023210778 @default.
• W3157478118 creator A5030130510 @default.
• W3157478118 creator A5030666435 @default.
• W3157478118 creator A5066111166 @default.
• W3157478118 creator A5066471308 @default.
• W3157478118 creator A5068107996 @default.
• W3157478118 creator A5069065380 @default.
• W3157478118 creator A5078776603 @default.
• W3157478118 creator A5079755926 @default.
• W3157478118 creator A5084888488 @default.
• W3157478118 date "2021-04-27" @default.
• W3157478118 modified "2023-09-26" @default.
• W3157478118 title "Identification of candidate PAX2-regulated genes implicated in human kidney development" @default.
• W3157478118 cites W1981463428 @default.
• W3157478118 cites W1982379359 @default.
• W3157478118 cites W1986223165 @default.
• W3157478118 cites W1987034775 @default.
• W3157478118 cites W1999466077 @default.
• W3157478118 cites W2002159657 @default.
• W3157478118 cites W2014221662 @default.
• W3157478118 cites W2015845481 @default.
• W3157478118 cites W2025215675 @default.
• W3157478118 cites W2066111244 @default.
• W3157478118 cites W2069478265 @default.
• W3157478118 cites W2075131851 @default.
• W3157478118 cites W2096465161 @default.
• W3157478118 cites W2099313405 @default.
• W3157478118 cites W2102619694 @default.
• W3157478118 cites W2114104545 @default.
• W3157478118 cites W2114703458 @default.
• W3157478118 cites W2116228354 @default.
• W3157478118 cites W2124852687 @default.
• W3157478118 cites W2127973000 @default.
• W3157478118 cites W2129785061 @default.
• W3157478118 cites W2133465414 @default.
• W3157478118 cites W2142392761 @default.
• W3157478118 cites W2143416290 @default.
• W3157478118 cites W2147315710 @default.
• W3157478118 cites W2149442576 @default.
• W3157478118 cites W2154592003 @default.
• W3157478118 cites W2158217645 @default.
• W3157478118 cites W2169456326 @default.
• W3157478118 cites W2176166968 @default.
• W3157478118 cites W2404785042 @default.
• W3157478118 cites W2407045510 @default.
• W3157478118 cites W2543390157 @default.
• W3157478118 cites W2594176963 @default.
• W3157478118 cites W2596867059 @default.
• W3157478118 cites W2619033859 @default.
• W3157478118 cites W2619309548 @default.
• W3157478118 cites W2767871975 @default.
• W3157478118 cites W2769396370 @default.
• W3157478118 cites W2789166354 @default.
• W3157478118 cites W2795687816 @default.
• W3157478118 cites W2803499747 @default.
• W3157478118 cites W2887326710 @default.
• W3157478118 cites W2904111838 @default.
• W3157478118 cites W2943690268 @default.
• W3157478118 cites W2970191345 @default.
• W3157478118 cites W798940297 @default.
• W3157478118 doi "https://doi.org/10.1038/s41598-021-88743-1" @default.
• W3157478118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8079710" @default.
• W3157478118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33907292" @default.
• W3157478118 hasPublicationYear "2021" @default.
• W3157478118 type Work @default.
• W3157478118 sameAs 3157478118 @default.
• W3157478118 citedByCount "6" @default.
• W3157478118 countsByYear W31574781182022 @default.
• W3157478118 countsByYear W31574781182023 @default.
• W3157478118 crossrefType "journal-article" @default.
• W3157478118 hasAuthorship W3157478118A5005250682 @default.
• W3157478118 hasAuthorship W3157478118A5007831725 @default.
• W3157478118 hasAuthorship W3157478118A5010644445 @default.
• W3157478118 hasAuthorship W3157478118A5012216609 @default.
• W3157478118 hasAuthorship W3157478118A5015204894 @default.
• W3157478118 hasAuthorship W3157478118A5021082730 @default.
• W3157478118 hasAuthorship W3157478118A5022995997 @default.
• W3157478118 hasAuthorship W3157478118A5023210778 @default.
• W3157478118 hasAuthorship W3157478118A5030130510 @default.
• W3157478118 hasAuthorship W3157478118A5030666435 @default.
• W3157478118 hasAuthorship W3157478118A5066111166 @default.
• W3157478118 hasAuthorship W3157478118A5066471308 @default.
• W3157478118 hasAuthorship W3157478118A5068107996 @default.
• W3157478118 hasAuthorship W3157478118A5069065380 @default.
• W3157478118 hasAuthorship W3157478118A5078776603 @default.
• W3157478118 hasAuthorship W3157478118A5079755926 @default.
• W3157478118 hasAuthorship W3157478118A5084888488 @default.
• W3157478118 hasBestOaLocation W31574781181 @default.
• W3157478118 hasConcept C104317684 @default.
• W3157478118 hasConcept C107459253 @default.
• W3157478118 hasConcept C111936080 @default.

• next