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• W3157487910 abstract "Intracranial hemorrhage (including subarachnoid hemorrhage [SAH]) has been reported in 0.3%–1.2% of patients with coronavirus disease 2019 (COVID-19). However, no study has evaluated the risk of SAH in patients with COVID-19. We analyzed data from 62 health care facilities using the Cerner de-identified COVID-19 dataset. There were 86 (0.1%) and 376 (0.2%) patients with SAH among 85,645 patients with COVID-19 and 197,073 patients without COVID-19, respectively. In the multivariate model, there was a lower risk of SAH in patients with COVID-19 (odds ratio 0.5, 95% confidence interval 0.4–0.7, P < 0.0001) after adjusting for sex, age strata, race/ethnicity, hypertension, and nicotine dependence/tobacco use. The proportions of patients who developed pneumonia (58.1% vs. 21.3%, P < 0.0001), acute kidney injury (43% vs. 27.7%, P = 0.0005), septic shock (44.2% vs. 20.7%, P < 0.0001), and respiratory failure (64.0% vs. 39.1%, P < 0.0001) were significantly higher among patients with SAH and COVID-19 compared with patients without COVID-19. The in-hospital mortality among patients with SAH and COVID-19 was significantly higher compared with patients without COVID-19 (31.4% vs. 12.2%, P < 0.0001). The risk of SAH was not increased in patients with COVID-19. The higher mortality in patients with SAH and COVID-19 compared with patients without COVID-19 is likely mediated by higher frequency of systemic comorbidities." @default.
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• W3157487910 date "2021-07-01" @default.
• W3157487910 modified "2023-10-09" @default.
• W3157487910 title "Subarachnoid Hemorrhage and COVID-19: An Analysis of 282,718 Patients" @default.
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• W3157487910 doi "https://doi.org/10.1016/j.wneu.2021.04.089" @default.
• W3157487910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8086384" @default.
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